INT84244

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.75
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (IDUA) carbohydrate metabolic process (IDUA) lysosome (IDUA)
Anatomy Link Frequency
fibroblasts 2
brush 2
IDUA (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 95.40 Very High Very High Very High
Inflammation 23 26.96 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
nud 8 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron-deficiency Anemia 264 100.00 Very High Very High Very High
Disease 36 97.92 Very High Very High Very High
Congenital Anomalies 3 93.44 High High
Mucopolysaccharidoses 4 88.24 High High
Anaemia 100 87.44 High High
Weight Loss 11 84.96 Quite High
Body Weight 1 82.48 Quite High
Hemorrhage 46 78.88 Quite High
Diarrhoea 7 78.16 Quite High
Pressure Volume 2 Under Development 32 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we used a late generation lentiviral vector to evaluate the utility of this vector system for the transfer and expression of the human IDUA cDNA in MPS I fibroblasts.
Positive_regulation (transfer) of Gene_expression (expression) of IDUA cDNA in fibroblasts
1) Confidence 0.70 Published 2002 Journal Eur. J. Biochem. Section Abstract Doc Link 12047386 Disease Relevance 0.26 Pain Relevance 0.10
To evaluate the potential for treatment of the disease using a gene delivery approach, recombinant adeno-associated virus (rAAV) vectors were constructed and evaluated for expression of the human IDUA cDNA in transduced cells. 293 cells transduced with these AAV vectors contained IDUA activity at 0.5 to 1.4 micromol/mg x hr, 50- to 140-fold above background (control-transduced) levels.
Positive_regulation (evaluated) of Gene_expression (expression) of IDUA associated with disease
2) Confidence 0.50 Published 1999 Journal Hum. Gene Ther. Section Abstract Doc Link 10498248 Disease Relevance 0.35 Pain Relevance 0.09
The endoscopic findings were recorded as GI lesions causing IDA or not causing IDA.
Neg (not) Positive_regulation (causing) of Neg (not) Gene_expression (causing) of IDA associated with iron-deficiency anemia
3) Confidence 0.41 Published 2011 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC3014590 Disease Relevance 1.35 Pain Relevance 0
DMT-1 is inserted into the brush border membrane with overall increased expression in IDA; inorganic iron is also taken up by the integrin-mobilferrin-paraferritin (IMP) pathway.
Positive_regulation (increased) of Gene_expression (expression) of IDA in brush associated with iron-deficiency anemia
4) Confidence 0.40 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 0.26 Pain Relevance 0
Please note that the intent of this review is not a thorough or exhaustive coverage of IDA; in particular, specific populations, such as those receiving hemodialysis will not be discussed.
Neg (not) Positive_regulation (coverage) of Gene_expression (coverage) of IDA associated with iron-deficiency anemia
5) Confidence 0.29 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 1.52 Pain Relevance 0

General Comments

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