INT84245

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Context Info
Confidence 0.20
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.46
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cardiac valve 1
MPEG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 95.20 Very High Very High Very High
carpal tunnel syndrome 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 20 100.00 Very High Very High Very High
Valvular Heart Disease Other Than Mitral Valve Prolapse 2 100.00 Very High Very High Very High
Mucopolysaccharidoses 2 99.82 Very High Very High Very High
Mucopolysaccharidosis I 28 98.40 Very High Very High Very High
Congenital Anomalies 9 96.72 Very High Very High Very High
Coronary Heart Disease 3 85.24 High High
Neurologic Manifestations 1 75.92 Quite High
Disease Progression 3 56.40 Quite High
Lysosome Storage Disease 7 50.00 Quite Low
Syndrome 8 39.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent case report of two siblings with Hurler-Scheie syndrome who began ERT at 5 months and 5 years of age, respectively, suggests that many MPS I disease manifestations, including cardiac valve disease, can be prevented if ERT is begun at an early age, but only partially reversed or stabilized if begun at a later age (Gabrielli et al. 2009).
Negative_regulation (prevented) of MPS I in cardiac valve associated with valvular heart disease other than mitral valve prolapse, mucopolysaccharidosis i and disease
1) Confidence 0.20 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2903709 Disease Relevance 1.10 Pain Relevance 0
Mucopolysaccharidosis type I (MPS I), a deficiency in the lysosomal enzyme alpha-L-iduronidase (IDUA), is characterized by skeletal abnormalities, hepatosplenomegaly and neurological dysfunction.
Negative_regulation (deficiency) of MPS I associated with anesthesia, congenital anomalies and mucopolysaccharidoses
2) Confidence 0.02 Published 1999 Journal Hum. Gene Ther. Section Abstract Doc Link 10498248 Disease Relevance 0.36 Pain Relevance 0.10

General Comments

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