INT84250

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Context Info
Confidence 0.56
First Reported 1999
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 14
Disease Relevance 15.89
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (IDUA) carbohydrate metabolic process (IDUA) lysosome (IDUA)
Anatomy Link Frequency
upper 2
fibroblasts 1
IDUA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 53 89.00 High High
nud 26 86.16 High High
cva 6 80.80 Quite High
anesthesia 2 75.88 Quite High
cINOD 20 68.00 Quite High
aspirin 16 67.20 Quite High
tolerance 2 20.24 Low Low
Bile 4 19.08 Low Low
abdominal pain 14 5.00 Very Low Very Low Very Low
intrathecal 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron-deficiency Anemia 898 100.00 Very High Very High Very High
Celiac Disease 111 100.00 Very High Very High Very High
Anaemia 290 99.84 Very High Very High Very High
Disease 137 99.78 Very High Very High Very High
Malabsorption Syndromes 7 96.92 Very High Very High Very High
Inflammatory Bowel Disease 96 96.88 Very High Very High Very High
Gastritis 94 96.02 Very High Very High Very High
Infection 27 93.72 High High
Colon Cancer 43 93.52 High High
Cancer 91 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The endoscopic findings were recorded as GI lesions causing IDA or not causing IDA.
Neg (not) Positive_regulation (causing) of IDA associated with iron-deficiency anemia
1) Confidence 0.56 Published 2011 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC3014590 Disease Relevance 1.34 Pain Relevance 0
These results suggest that the lentiviral vector may be used for the delivery and expression of the IDUA gene to cells in vivo for treatment of MPS I.
Positive_regulation (delivery) of IDUA
2) Confidence 0.44 Published 2002 Journal Eur. J. Biochem. Section Abstract Doc Link 12047386 Disease Relevance 0.20 Pain Relevance 0.07
Transduced MPS I fibroblasts also expressed high levels of IDUA activity (114-290 nmol/mg x hr), which persisted for at least 3 weeks in the absence of selection.
Positive_regulation (levels) of IDUA in fibroblasts
3) Confidence 0.41 Published 1999 Journal Hum. Gene Ther. Section Abstract Doc Link 10498248 Disease Relevance 0.37 Pain Relevance 0.08
Therefore, as functional IDUA is provided by donor cells, HCT has the ability to provide the enzyme in a manner akin to ERT, except on a continuous rather than intermittent basis.
Positive_regulation (provided) of IDUA
4) Confidence 0.39 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727896 Disease Relevance 0.06 Pain Relevance 0
The celiac disease as a possible cause of IDA refractory to oral iron treatment, without other apparent manifestations of malabsorption syndrome is increasingly being recognized.
Spec (possible) Positive_regulation (cause) of IDA associated with celiac disease, iron-deficiency anemia and malabsorption syndromes
5) Confidence 0.38 Published 2011 Journal International Journal of Medical Sciences Section Body Doc Link PMC3014590 Disease Relevance 1.76 Pain Relevance 0
In this study, we aimed to evaluate the diagnostic yield of endoscopy in patients with IDA and to define predictive factors of gastrointestinal (GI) lesions causing IDA and identify clinical and biochemical variables that predict the outcome of upper/lower endoscopy in outpatients with iron deficiency anemia.
Positive_regulation (causing) of IDA in upper associated with iron-deficiency anemia
6) Confidence 0.38 Published 2011 Journal International Journal of Medical Sciences Section Body Doc Link PMC3014590 Disease Relevance 1.57 Pain Relevance 0
But, the previous studies have found that symptoms and signs are poor indicators of the site of lesions causing IDA and, thus, are not helpful in choosing appropriate investigative tests 34-35.
Positive_regulation (causing) of IDA associated with iron-deficiency anemia
7) Confidence 0.38 Published 2011 Journal International Journal of Medical Sciences Section Body Doc Link PMC3014590 Disease Relevance 0.88 Pain Relevance 0
In our study, predictive risk factors for GI tract lesions to cause of IDA were older age (>50 years) and positive FOBT.
Positive_regulation (cause) of IDA associated with iron-deficiency anemia
8) Confidence 0.38 Published 2011 Journal International Journal of Medical Sciences Section Body Doc Link PMC3014590 Disease Relevance 1.42 Pain Relevance 0.04
By using multiple logistic regression analysis, no statistically significant risk factor for the presence of upper-GI tract diseases likely to cause IDA was identified.
Positive_regulation (cause) of IDA in upper associated with iron-deficiency anemia and disease
9) Confidence 0.38 Published 2011 Journal International Journal of Medical Sciences Section Body Doc Link PMC3014590 Disease Relevance 1.18 Pain Relevance 0.04
In this study, we aimed to evaluate the diagnostic yield of endoscopy in patients with IDA and to define predictive factors of gastrointestinal (GI) lesions causing IDA.
Positive_regulation (causing) of IDA associated with iron-deficiency anemia
10) Confidence 0.38 Published 2011 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC3014590 Disease Relevance 1.26 Pain Relevance 0
Although this review is necessarily focused on the pathogenesis, etiology, diagnosis, and treatment of IDA, and not other causes of anemia, recognition that anemia is not due to IDA can provide valuable information for the referring practitioner.
Neg (not) Positive_regulation (due) of IDA associated with anaemia and iron-deficiency anemia
11) Confidence 0.29 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 1.47 Pain Relevance 0
Of the 35 women with GI lesions, 47% were diagnosed with H. pylori (Hp) gastritis and 17% with celiac disease, with the authors recommending routine use of the urea breath test and celiac serologies in their population, with endoscopic evaluation reserved only for those who test negative for Hp or celiac disease or whose IDA fails to resolve after Hp eradication [47].
Positive_regulation (negative) of IDA associated with celiac disease, iron-deficiency anemia and gastritis
12) Confidence 0.29 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 1.28 Pain Relevance 0.10
In many patients, after appropriate GI evaluation is performed, the cause of IDA is still not identified.
Positive_regulation (cause) of IDA associated with iron-deficiency anemia
13) Confidence 0.27 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 2.45 Pain Relevance 0.21
In IDA, DMT-1 is upregulated, which increases zinc transport across the intestinal membrane to replace the missing iron in the formation of the protoporphyrin ring [38].
Positive_regulation (upregulated) of IDA associated with iron-deficiency anemia
14) Confidence 0.14 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 0.65 Pain Relevance 0.08

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