INT84260

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2011
Negated 3
Speculated 7
Reported most in Abstract
Documents 124
Total Number 132
Disease Relevance 72.84
Pain Relevance 35.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
neurons 10
lung 7
brain 6
spinal 5
spinal cord 3
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 636 100.00 Very High Very High Very High
Paracetamol 30 99.98 Very High Very High Very High
ischemia 1122 99.96 Very High Very High Very High
amygdala 96 99.92 Very High Very High Very High
Dopamine 573 99.84 Very High Very High Very High
nMDA receptor 170 99.84 Very High Very High Very High
Morphine 65 99.84 Very High Very High Very High
dorsal root ganglion 19 99.84 Very High Very High Very High
Kinase C 158 99.76 Very High Very High Very High
Hippocampus 440 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 996 100.00 Very High Very High Very High
INFLAMMATION 833 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 88 100.00 Very High Very High Very High
Cv Unclassified Under Development 359 99.96 Very High Very High Very High
Apoptosis 1019 99.90 Very High Very High Very High
Ganglion Cysts 70 99.84 Very High Very High Very High
Hypoxia 355 99.82 Very High Very High Very High
Cv General 4 Under Development 671 99.72 Very High Very High Very High
Diabetes Mellitus 21 99.68 Very High Very High Very High
Death 483 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An intra-plantar (i.pl.) injection of complete Freund's adjuvant induced the activation of JNK in DRG neurons within 30 min.
Positive_regulation (activation) of JNK in DRG associated with dorsal root ganglion
1) Confidence 0.69 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16055088 Disease Relevance 1.33 Pain Relevance 0.88
RESULTS: In control rats, activated JNK and c-Jun were primarily associated with mechanoceptors; in diabetes this was increased, but a greater increase was seen in nociceptors.
Positive_regulation (activated) of JNK in nociceptors
2) Confidence 0.68 Published 2006 Journal Diabetologia Section Body Doc Link 16456679 Disease Relevance 0 Pain Relevance 0
Fifteen days after injury, the analysis in the sciatic nerves highlighted a bilateral increase of the activated forms of PKCgamma, ERK 1,2 and SAP/JNK, whereas c-Jun showed an increase only ipsilaterally.
Positive_regulation (increase) of JNK in sciatic nerves associated with injury and sciatic nerve
3) Confidence 0.67 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.57 Pain Relevance 0.60
However, activation of both p44/42 and SAPK/JNK in response to LPS, was significantly lower in the SLH rats when compared to shams.
Positive_regulation (activation) of JNK associated with cva
4) Confidence 0.67 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 1.04 Pain Relevance 0.74
To explore the underlying mechanisms, effects of edaravone on the excitability of dorsal root ganglion (DRG) neurons and activation of JNK in DRG were observed.
Positive_regulation (activation) of JNK in neurons associated with ganglion cysts and dorsal root ganglion
5) Confidence 0.63 Published 2009 Journal Brain Res. Section Abstract Doc Link 19028459 Disease Relevance 1.65 Pain Relevance 1.88
Intraplantar injection of sterile saline solution, causing acute and transient pain, produced almost the same changes in activation profile of the two JNK isoforms as found in the BV-treated rats.
Positive_regulation (activation) of JNK associated with pain
6) Confidence 0.50 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17923323 Disease Relevance 0.33 Pain Relevance 0.55
Nevertheless, JNK 46 kDa exhibited a much higher activation than JNK 54 kDa in the spinal cord, whereas the same noxious stimulation elicited evident activation of JNK 54 kDa in the S1 area, leaving JNK 46 kDa less affected.
Spec (evident) Positive_regulation (activation) of JNK in spinal cord associated with spinal cord
7) Confidence 0.50 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17923323 Disease Relevance 0.32 Pain Relevance 0.56
Fifteen days after injury, the analysis in the sciatic nerves highlighted a bilateral increase of the activated forms of PKCgamma, ERK 1,2 and SAP/JNK, whereas c-Jun showed an increase only ipsilaterally.
Positive_regulation (activated) of JNK in sciatic nerves associated with injury and sciatic nerve
8) Confidence 0.49 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.56 Pain Relevance 0.60
-dependent activation of c-Jun N-terminal kinase (JNK) [70], [71].
Positive_regulation (activation) of c-Jun N-terminal kinase
9) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.08 Pain Relevance 0.04
JNK activation was determined by monitoring phosphorylation of JNK (Thr183 and Tyr185) and c-Jun (Ser63), which is a substrate of JNK.
Positive_regulation (activation) of JNK
10) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.83 Pain Relevance 0.12
Besides being activated by TLR4, JNK activity is induced in different pathophysiological states including infection, inflammation, obesity and hyperlipidemia, also as a consequence of ER stress [66], [67], [68].
Positive_regulation (induced) of JNK associated with stress, inflammation, obesity, hyperlipidemia and infection
11) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.09 Pain Relevance 0.11
-dependent activation of c-Jun N-terminal kinase (JNK) [70], [71].
Positive_regulation (activation) of JNK
12) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.08 Pain Relevance 0.04
Taken together, we conclude that activation of peripheral MAPKs, including ERK, JNK and p38, might contribute to the induction and maintenance of persistent ongoing pain and primary heat hyperalgesia in the melittin test.
Positive_regulation (activation) of JNK associated with pain and hyperalgesia
13) Confidence 0.46 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329815 Disease Relevance 1.02 Pain Relevance 0.93
These findings demonstrated for the first time that NMDA receptor-dependent activation of the spinal JNK contributes to morphine antinociceptive tolerance and that MK-801 attenuates morphine tolerance partly due to its inhibition on the spinal JNK activation.
Positive_regulation (activation) of JNK in spinal associated with nmda receptor, tolerance, antinociceptive and morphine
14) Confidence 0.46 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.61
However, whether chronic morphine-induced activation of the spinal JNK is NMDA receptor-dependent is unknown.
Spec (whether) Positive_regulation (activation) of JNK in spinal associated with nmda receptor and morphine
15) Confidence 0.46 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 0.93
NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance.
Positive_regulation (activation) of JNK in spinal associated with nmda receptor, tolerance, antinociceptive and morphine
16) Confidence 0.46 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.38
Our results showed that chronic morphine treatment induced upregulation of the NR2B expression and activation of JNK in the spinal cord.
Positive_regulation (activation) of JNK in spinal cord associated with spinal cord and morphine
17) Confidence 0.46 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.32
MK-801, a noncompetitive NMDA receptor antagonist, not only suppressed morphine antinociceptive tolerance and the increase in NR2B, but also reduced the spinal JNK activation induced by chronic morphine treatment.
Positive_regulation (activation) of JNK in spinal associated with nmda receptor antagonist, tolerance, antinociceptive and morphine
18) Confidence 0.46 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.63
The present study investigated the link between the spinal NMDA receptor NR2B subunit and the JNK activation during morphine antinociceptive tolerance in rats.
Spec (investigated) Positive_regulation (activation) of JNK in spinal associated with nmda receptor, tolerance, antinociceptive and morphine
19) Confidence 0.46 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.20
Consistent with our in vivo data, Ishii et al. [34] have reported that both JNK and ERK were simultaneously activated in the lung during ischemia and reperfusion.
Positive_regulation (activated) of JNK in lung associated with ischemia
20) Confidence 0.46 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.76 Pain Relevance 0.15

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