INT84264

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 2
Speculated 5
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 21.18
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (NPPB) extracellular region (NPPB) nucleus (NPPB)
cytoplasm (NPPB)
Anatomy Link Frequency
heart 4
ANP 2
plasma 1
thyroid 1
body 1
NPPB (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 34 96.56 Very High Very High Very High
Inflammation 196 95.80 Very High Very High Very High
Catecholamine 25 95.16 Very High Very High Very High
cva 35 94.08 High High
Angina 328 87.20 High High
imagery 9 77.20 Quite High
ischemia 222 73.28 Quite High
agonist 1 66.00 Quite High
Potency 3 58.96 Quite High
cytokine 38 37.44 Quite Low
Disease Link Frequency Relevance Heat
Thyroid Disease 12 99.72 Very High Very High Very High
Natriuresis 206 99.66 Very High Very High Very High
Obesity 202 99.62 Very High Very High Very High
Infarction 47 99.08 Very High Very High Very High
Acute Coronary Syndrome 647 98.96 Very High Very High Very High
Disorders Of Creatine Metabolism 9 98.92 Very High Very High Very High
Myocardial Infarction 506 98.80 Very High Very High Very High
Endocrine Disease 3 98.28 Very High Very High Very High
Coronary Heart Disease 47 97.92 Very High Very High Very High
Pain 33 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B-Type natriuretic peptide (BNP) and aminoterminal pro-brain natriuretic peptide (NT-proBNP) are believed to correlate with the severity of heart failure symptoms and objective measures of heart function.1-3) The NT-proBNP levels are affected by demographic variables such as age, gender, and ethnicity, and clinical characteristics such as hypertension, atrial fibrillation, and renal function.4-6) Elevated body mass index (BMI) and obesity have been associated with hypertension, insulin resistance and dyslipidemia, and contribute to deleterious hemodynamic and morphologic cardiovascular changes.7-9) Recent studies demonstrated that obesity is associated with decreased levels of NT-proBNP and raised concerns about the diagnostic and prognostic validity of natriuretic peptides in obese patients.10)11) NT-proBNP has been shown to be increased in patients with diabetes mellitus (DM), even in the absence of structural heart disease, and obesity frequently coexists with diabetes.
Regulation (affected) of NT-proBNP in heart associated with natriuresis, diabetes mellitus, insulin resistance, heart disease, hypertension, obesity, arrhythmias 2 under development and myocardial infarction
1) Confidence 0.61 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 1.89 Pain Relevance 0
Changes in plasma BNP and ANP levels did not differ between the groups (P=0.212 and 0.356).
Regulation (Changes) of BNP in BNP
2) Confidence 0.60 Published 2009 Journal Acta Anaesthesiol Scand Section Body Doc Link 19419350 Disease Relevance 0 Pain Relevance 0
Among various laboratory data, the peak levels of creatine kinase MB (CK-MB), TnI, and N-terminal pro b-type natriuretic peptide (NT-pro-BNP) were evaluated for estimation of the infarction burden.
Regulation (evaluated) of BNP associated with natriuresis and infarction
3) Confidence 0.44 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771835 Disease Relevance 1.00 Pain Relevance 0.07
Age, gender, body mass index, and race seem to affect the normal range of BNP.
Spec (seem) Regulation (affect) of BNP in body associated with obesity
4) Confidence 0.39 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.72 Pain Relevance 0.04
We also tested a group of NPPB analogs on TRPA1 channel activities.
Regulation (group) of NPPB
5) Confidence 0.39 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20226176 Disease Relevance 0.22 Pain Relevance 0.20
This effect takes some time to develop as the NT-proBNP concentrations were unchanged immediately after the courses (t = 4 h).
Neg (unchanged) Regulation (unchanged) of NT-proBNP
6) Confidence 0.37 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.33 Pain Relevance 0.05
We investigated the influence of human BNP 32 and its fragment BNP 7-32 on the production of superoxide anion by PMN, a major cause for myocardial damage.
Spec (investigated) Regulation (influence) of BNP
7) Confidence 0.27 Published 1999 Journal Life Sci. Section Abstract Doc Link 10499870 Disease Relevance 0.52 Pain Relevance 0.09
At admission, the serum NT-proBNP values were 116 ± 21 pg/mL in group A versus 209 ± 93 pg/mL in group B.
Regulation (values) of NT-proBNP
8) Confidence 0.24 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2592747 Disease Relevance 1.22 Pain Relevance 0
Further exclusion criteria to eliminate bias by pre-existent alterations of NT-proBNP were previous cardiac, renal, hepatic, or endocrine diseases prior to admission (for exclusion criteria, see Figure 1).
Regulation (alterations) of NT-proBNP associated with endocrine disease
9) Confidence 0.24 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 1.13 Pain Relevance 0.05
This suggests that factors other than cardiac status affect NT-proBNP concentrations.



Regulation (affect) of NT-proBNP
10) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2801462 Disease Relevance 1.68 Pain Relevance 0
In addition, although the accuracy of the test was high, in some patients, their clinical results did not correlate to the NT-proBNP value.
Regulation (value) of NT-proBNP
11) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 0.76 Pain Relevance 0.12
The most important findings of this study are the observed change in NT-proBNP and prolonged QTc-intervals.
Spec (observed) Regulation (change) of NT-proBNP
12) Confidence 0.22 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.05 Pain Relevance 0.03
Changes in plasma BNP and ANP levels did not differ between the groups (P=0.212 and 0.356).
Regulation (Changes) of BNP in ANP
13) Confidence 0.20 Published 2009 Journal Acta Anaesthesiol Scand Section Body Doc Link 19419350 Disease Relevance 0 Pain Relevance 0
The role of BNP and NT-proBNP testing is included in the guidelines for the diagnosis and treatment of chronic heart failure of the task force of the European Society of Cardiology, published in 2005.
Regulation (role) of BNP in heart associated with myocardial infarction
14) Confidence 0.14 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.61 Pain Relevance 0
Worsening renal function affects clearance of NT-proBNP greater than BNP (Weber M and Hamm C, 2006), however deFilippi et al. have recently shown that the diagnostic accuracies of BNP and NT-proBNP in detecting decompensated heart failure are similar in patients with or without renal failure and that NT-proBNP is superior to BNP in predicting mortality (deFilippi CR et al. 2007).
Regulation (affects) of NT-proBNP in heart associated with renal failure and acute decompensated heart failure (adhf)
15) Confidence 0.14 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.82 Pain Relevance 0.03
The role of BNP and NT-proBNP testing is included in the guidelines for the diagnosis and treatment of chronic heart failure of the task force of the European Society of Cardiology, published in 2005.
Regulation (role) of NT-proBNP in heart associated with myocardial infarction
16) Confidence 0.14 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.62 Pain Relevance 0
The understanding of its biochemistry is far from complete, in particular post-translational metabolism of the peptides, which may affect accurate determination of the levels of active BNP [32].
Spec (may) Regulation (affect) of BNP
17) Confidence 0.09 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.95 Pain Relevance 0
In all studies elevated values of BNP and NT-proBNP have consistently been found.
Regulation (values) of BNP
18) Confidence 0.09 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.96 Pain Relevance 0.21
Similar results were reported for the predictive value of BNP and NT-proBNP after STEMI.
Regulation (value) of BNP
19) Confidence 0.09 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.87 Pain Relevance 0.05
Similar results were reported for the predictive value of BNP and NT-proBNP after STEMI.
Regulation (value) of NT-proBNP
20) Confidence 0.09 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.87 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox