INT84284

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Context Info
Confidence 0.35
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.81
Pain Relevance 5.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flvcr2) transmembrane transport (Flvcr2)
Anatomy Link Frequency
spinal 1
neurons 1
striatum 1
external 1
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 171 100.00 Very High Very High Very High
Dopamine 37 100.00 Very High Very High Very High
gABA 29 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
nMDA receptor 17 99.56 Very High Very High Very High
tetrodotoxin 6 97.76 Very High Very High Very High
Action potential 9 97.24 Very High Very High Very High
Kinase C 19 94.24 High High
ischemia 50 93.24 High High
spinal dorsal horn 9 84.96 Quite High
Disease Link Frequency Relevance Heat
Nociception 15 93.92 High High
Cv Unclassified Under Development 47 93.24 High High
Lactic Acidosis 1 72.96 Quite High
Pain 13 25.16 Quite Low
Neuropathic Pain 4 10.72 Low Low
Hypoxia 8 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results compared to data in the literature suggest that the first increase in extracellular DA resulted mainly from a release of cytosolic DA by reversal of the DA transporter, while the second was mainly due to a release of vesicular DA by exocytosis.
Localization (release) of transporter associated with dopamine
1) Confidence 0.35 Published 1999 Journal Neuroreport Section Abstract Doc Link 10501541 Disease Relevance 0.07 Pain Relevance 0.60
Other results indicate that the reduction of exocytotic NE release is independent of L- and N-type VSCC, classical drug/peptide binding sites on VSCC, Na+ channels, alpha2-adrenoceptors, NE transporter, and system L amino acid transporter.
Localization (release) of NE transporter
2) Confidence 0.31 Published 2002 Journal Synapse Section Abstract Doc Link 12112396 Disease Relevance 0 Pain Relevance 0.39
Fenfluramine releases serotonin (5-HT) via the 5-HT transporter (SERT).
Localization (releases) of transporter associated with serotonin
3) Confidence 0.11 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.41
This delay in the onset suggests that intracellular energy depletion is a slow process under our experimental conditions and transporter reversal does not occur before intracellular energy is substantially depleted.
Localization (reversal) of transporter
4) Confidence 0.10 Published 2007 Journal Mol Pain Section Body Doc Link PMC1864984 Disease Relevance 0.55 Pain Relevance 0.85
Synergistically interacting dopamine D1 and NMDA receptors mediate nonvesicular transporter-dependent GABA release from rat striatal medium spiny neurons.
Localization (release) of transporter in neurons associated with gaba, dopamine and nmda receptor
5) Confidence 0.09 Published 2000 Journal J. Neurosci. Section Title Doc Link 10777812 Disease Relevance 0 Pain Relevance 0.96
Like NMDA receptor-mediated [(3)H]-GABA release, that induced by prolonged (20 min) dopamine D1 receptor activation was enhanced on omission of external calcium, was action potential-independent (tetrodotoxin-insensitive), and was diminished by the GABA transporter blocker nipecotic acid, indicating the involvement of transporter-mediated release.
Localization (release) of transporter in external associated with tetrodotoxin, action potential, dopamine, gaba and nmda receptor
6) Confidence 0.09 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10777812 Disease Relevance 0 Pain Relevance 0.99
Given the complex interactions between dopamine D1 and glutamate NMDA receptors in the striatum, we investigated the role of these receptors in transporter-mediated GABA release from cultured medium spiny neurons of rat striatum.
Localization (release) of transporter in striatum associated with gaba, glutamate, dopamine and nmda receptor
7) Confidence 0.09 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10777812 Disease Relevance 0 Pain Relevance 0.66
The constancy of time course of glutamate transporter currents across stimulus intensities indicate that spinal astrocytes use similar transporter capacity to manage glutamate release from both sets of afferents and additionally that there is normally a reserve capacity for both types of inputs [39].
Localization (release) of transporter in spinal associated with glutamate
8) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0.19 Pain Relevance 0.43

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