INT84310

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Context Info
Confidence 0.29
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 6.60
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
hepatocyte 2
liver 2
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 55 98.90 Very High Very High Very High
Chronic pancreatitis 10 98.48 Very High Very High Very High
pulpitis 2 97.96 Very High Very High Very High
Paracetamol 1 95.28 Very High Very High Very High
Inflammation 58 93.96 High High
cytokine 10 62.84 Quite High
Pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 154 100.00 Very High Very High Very High
Cirrhosis 8 99.30 Very High Very High Very High
Cancer 254 98.94 Very High Very High Very High
Fibrosis 27 98.90 Very High Very High Very High
Pancreatitis 10 98.48 Very High Very High Very High
Pulpitis 2 97.96 Very High Very High Very High
Hepatotoxicity 1 96.24 Very High Very High Very High
Metastasis 212 95.72 Very High Very High Very High
Hyperglycemia 2 94.84 High High
Injury 49 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The controlled presentation of TGF-beta1 enhanced hepatocyte functions in microfluidic systems without the complications of co-cultures, allowing for simplifications in drug testing and other hepatocyte-based applications.
Regulation (controlled) of Gene_expression (presentation) of TGF-beta1 in hepatocyte
1) Confidence 0.29 Published 2009 Journal Biomaterials Section Abstract Doc Link 19394078 Disease Relevance 0.10 Pain Relevance 0.10
AIM: To evaluate the Transforming Growth Factor-beta 1 (TGF-beta 1) expression in normal healthy pulps and in those with irreversible pulpitis.
Regulation (evaluate) of Gene_expression (expression) of Transforming Growth Factor-beta 1 associated with pulpitis
2) Confidence 0.26 Published 2004 Journal Int Endod J Section Abstract Doc Link 14871177 Disease Relevance 0.17 Pain Relevance 0.17
In conclusion: serum biochemical markers of liver fibrosis can be considered of limited value in assessing pancreatic fibrosis; in liver cirrhosis there may be a negative feed-back regulation between TGFb production and the fibrogenetic process; and in chronic pancreatitis TGFb appears to favor fibrosis on the one hand and the development of hyperglycemia on the other.
Regulation (regulation) of Gene_expression (production) of TGFb in liver associated with hyperglycemia, fibrosis, cirrhosis and chronic pancreatitis
3) Confidence 0.18 Published 1998 Journal J Med Section Abstract Doc Link 10503164 Disease Relevance 1.75 Pain Relevance 0.89
Cilomilast had no significant effect on the expression of late remodeling markers such as transforming growth factor (TGF)-?
Neg (no) Regulation (effect) of Gene_expression (expression) of transforming growth factor
4) Confidence 0.10 Published 2010 Journal BMC Pulm Med Section Abstract Doc Link PMC2881047 Disease Relevance 0.80 Pain Relevance 0.35
Effect on expression of TGF-?
Regulation (Effect) of Gene_expression (expression) of TGF
5) Confidence 0.09 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 0.79 Pain Relevance 0.13
in the tumor cells had no additional effect, suggesting parallel roles for hypoxia and TGF-?
Regulation (roles) of Gene_expression (hypoxia) of TGF associated with hypoxia and cancer
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.68 Pain Relevance 0
1 (5 ng/mL) and ± 1% O2 for 24 h were then surveyed by semi-quantitative RT-PCR for changes in mRNA expression of candidate TGF-?
Regulation (changes) of Gene_expression (expression) of TGF
7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.31 Pain Relevance 0

General Comments

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