INT84320

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.00
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) oxidoreductase activity (Mpo)
lysosome (Mpo)
Anatomy Link Frequency
paw 5
brain 2
lung 2
neutrophils 2
skin 1
Mpo (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 121 99.56 Very High Very High Very High
Paracetamol 14 99.36 Very High Very High Very High
Dopamine 2 93.76 High High
antagonist 14 90.68 High High
chemokine 3 90.12 High High
cerebral cortex 1 89.08 High High
Antinociceptive 1 86.40 High High
dexamethasone 2 82.72 Quite High
cytokine 77 80.40 Quite High
b2 receptor 1 78.56 Quite High
Disease Link Frequency Relevance Heat
Injury 119 100.00 Very High Very High Very High
Urological Neuroanatomy 56 100.00 Very High Very High Very High
Pressure And Volume Under Development 19 100.00 Very High Very High Very High
Pleurisy 3 100.00 Very High Very High Very High
INFLAMMATION 137 99.56 Very High Very High Very High
Burns 112 98.52 Very High Very High Very High
Necrosis 7 95.36 Very High Very High Very High
Endotoxemia 16 93.36 High High
Nociception 9 90.16 High High
Cancer 7 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the histological changes observed in these tissues, the LPS-mediated increase in MPO level were decreased following PAF treatment, indicating attenuated PMN recruitment (Figure 3B).
Negative_regulation (decreased) of Positive_regulation (increase) of MPO associated with urological neuroanatomy
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.81 Pain Relevance 0.08
Enhancement of both cell migration and myeloperoxidase levels, 4 h after pleurisy induction, was effectively inhibited by all studied drugs.
Negative_regulation (inhibited) of Positive_regulation (Enhancement) of myeloperoxidase associated with pleurisy
2) Confidence 0.43 Published 1999 Journal Peptides Section Abstract Doc Link 10503773 Disease Relevance 0.34 Pain Relevance 0.28
Systemic inflammation and the intensity of MPO activation in the brain were significantly reduced throughout the 1 month post-injury period as compared to mice either with whole-body exposure to blast or those with head protection.
Negative_regulation (reduced) of Positive_regulation (activation) of MPO in brain associated with inflammation, injury and urological neuroanatomy
3) Confidence 0.42 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 1.11 Pain Relevance 0.25
In addition, trypsin produced an increase in myeloperoxidase (MPO) activity, which was significantly reduced in PAR-2-deficient mice.
Negative_regulation (reduced) of Positive_regulation (increase) of MPO associated with urological neuroanatomy
4) Confidence 0.41 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18083162 Disease Relevance 0.97 Pain Relevance 0.21
Furthermore, an 8 days treatment with budlein A inhibited Complete Freund's adjuvant (10 microl/paw)-induced hypernociception, paw oedema and paw skin myeloperoxidase activity increase while not affecting the motor performance or myeloperoxidase activity in the stomach.
Negative_regulation (inhibited) of in paw Positive_regulation (increase) of myeloperoxidase in skin associated with pressure and volume under development
5) Confidence 0.40 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320857 Disease Relevance 0.70 Pain Relevance 0.50
However, Oral antibiotics treatment led to a significant 68% decrease (28.09 ± 4.97 vs. 87 ± 8.17 Units/g tissue) of thermal injury-induced lung MPO activity in comparison with that of burn group (Figure 2B).
Negative_regulation (decrease) of Positive_regulation (induced) of MPO in lung associated with burns, injury and urological neuroanatomy
6) Confidence 0.39 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.52 Pain Relevance 0.03
Consistent with this, we also observed ulceration-induced MPO activity up to the third day, followed by its gradual reduction on the seventh day (Table 3).
Negative_regulation (reduction) of Positive_regulation (induced) of MPO associated with urological neuroanatomy
7) Confidence 0.39 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2976071 Disease Relevance 0.65 Pain Relevance 0.11
The SMWE (10 mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue.
Negative_regulation (inhibited) of Positive_regulation (induced) of MPO in paw
8) Confidence 0.23 Published 2003 Journal Clin. Chim. Acta Section Body Doc Link 12559597 Disease Relevance 0 Pain Relevance 0
Additionally, both niranthin and WEB2170 (30 nmol/paw) inhibited the increase of myeloperoxidase activity induced by PAF injection in the mouse paw.
Negative_regulation (inhibited) of Positive_regulation (increase) of myeloperoxidase in paw
9) Confidence 0.18 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16925995 Disease Relevance 0.52 Pain Relevance 0.32
Furthermore, GGA inhibited increases in hepatic lipid peroxide content and hepatic myeloperoxidase activity after APAP administration.
Negative_regulation (inhibited) of Positive_regulation (increases) of hepatic myeloperoxidase associated with paracetamol
10) Confidence 0.08 Published 2006 Journal Toxicology Section Abstract Doc Link 16377054 Disease Relevance 0.70 Pain Relevance 1.14
These were significantly reduced by rosiglitazone, which also produced a 71% reduction of the increase in myeloperoxidase activity (a marker for the presence of neutrophils) and an 84% reduction of the increase in malondialdehyde levels.
Negative_regulation (reduction) of Positive_regulation (increase) of myeloperoxidase in neutrophils
11) Confidence 0.07 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.68 Pain Relevance 0.17

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