INT84333

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.48
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
platelets 3
blood 1
plasma 1
THROMBIN (Oryctolagus cuniculus)
Pain Term Frequency Confidence Heat
aspirin 219 91.04 High High
agonist 9 88.44 High High
adenocard 9 86.16 High High
Angina 45 80.96 Quite High
imagery 1 80.12 Quite High
Pain 1 65.20 Quite High
Bioavailability 4 56.48 Quite High
antagonist 3 39.28 Quite Low
cva 74 31.64 Quite Low
ischemia 42 29.64 Quite Low
Disease Term Frequency Confidence Heat
Disseminated Intravascular Coagulation 15 98.98 Very High Very High Very High
Syndrome 17 97.84 Very High Very High Very High
Acute Coronary Syndrome 99 95.92 Very High Very High Very High
Hemorrhage 214 94.32 High High
Heparin-induced Thrombocytopenia 37 93.60 High High
Injury 7 90.40 High High
Thrombophilia 3 89.80 High High
Adhesions 3 89.04 High High
Congenital Anomalies 4 83.84 Quite High
Cv General 3 Under Development 108 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The natural leech-derived polypeptide hirudin and its derivatives (e.g., lepirudin) inactivate both fibrin-bound and free thrombin.
fibrin Binding (bound) of thrombin
1) Confidence 0.40 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10505536 Disease Relevance 1.58 Pain Relevance 0.28
It is important to note that heparins do not inhibit thrombin bound to fibrin, thrombin bound to fibrin degradation products, or Factor Xa bound to platelets (Mirshahi et al 1989; Furie and Furie 1992; Hogg and Bock, 1997).
fibrin Binding (bound) of thrombin in platelets
2) Confidence 0.14 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515410 Disease Relevance 0.54 Pain Relevance 0.11
It is able to inactivate both free thrombin and thrombin bound to fibrin.
fibrin Binding (bound) of thrombin
3) Confidence 0.11 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59637 Disease Relevance 0.29 Pain Relevance 0.07
Third, thrombin also binds to fibrin and to the subendothelial matrix, where it is shielded from the heparin-antithrombin-III complex [41,42,43].
fibrin Binding (binds) of thrombin
4) Confidence 0.11 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59637 Disease Relevance 0.20 Pain Relevance 0.38
Thrombin binds to fibrin particles and continues to strongly activate platelets (Kumar et al 1995); activate Factors V, VIII, and XIII (which further stimulate thrombin production and stabilize the fibrin-bound thrombin) (Kumar et al 1994; Sciulli and Mauro 2002); convert fibrinogen to fibrin (Weitz et al 1990); and activate carboxypeptidase B, a known fibrinolysis inhibitor (Sakharov et al 1997; Fenton et al 1998).
fibrin Binding (binds) of Thrombin in platelets
5) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515410 Disease Relevance 0.48 Pain Relevance 0.04
It is important to note that heparins do not inhibit thrombin bound to fibrin, thrombin bound to fibrin degradation products, or Factor Xa bound to platelets (Mirshahi et al 1989; Furie and Furie 1992; Hogg and Bock, 1997).
fibrin Binding (bound) of thrombin in platelets
6) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515410 Disease Relevance 0.53 Pain Relevance 0.11
Furthermore, unfractionated heparin might not be effective because it binds to the complex of thrombin and fibrin, thereby shielding it from inactivation by the heparin-antithrombin complex [90].
fibrin Spec (might) Binding (complex) of thrombin
7) Confidence 0.09 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59637 Disease Relevance 0.15 Pain Relevance 0.21
However, the efficacy of such treatment is known to be suboptimal, probably due to the several pharmacokinetic (ie, binding to plasma proteins with consequent variable anticoagulant response) and biophysical (ie, inability to inactivate factor Xa in the prothrombinase complex and thrombin bound to fibrin) limitations of UFH (Hirsh et al 2001).
fibrin Binding (bound) of thrombin in plasma
8) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291313 Disease Relevance 0.13 Pain Relevance 0.03
Once bleeding complications occur, identification of the pathophysiologic mechanism leading to the hemostasis imbalance is critical, that is, whether there is a platelet pooling like in KMS as opposed to continuous local intravascular coagulation that consumes coagulation factors, leading to the formation of thrombin and fibrin within anatomical structures that either slow down or distort the blood stream.
fibrin Binding (formation) of thrombin in blood associated with syndrome, disseminated intravascular coagulation and hemorrhage
9) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848681 Disease Relevance 1.57 Pain Relevance 0.11

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