INT84367

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Context Info
Confidence 0.15
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 36
Disease Relevance 25.36
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (S100a7a) biological_process (S100a7a) cytoplasm (S100a7a)
Anatomy Link Frequency
MDA-MB-468 6
tibia 2
MCF-7 2
lymph node 1
bladder 1
S100a7a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 70 95.96 Very High Very High Very High
Serotonin 2 93.40 High High
Neuropeptide 3 90.16 High High
Enkephalin 3 89.48 High High
alcohol 35 89.36 High High
anesthesia 35 66.96 Quite High
cytokine 175 59.24 Quite High
Buprenorphine 35 48.16 Quite Low
Analgesic 35 45.84 Quite Low
imagery 70 12.64 Low Low
Disease Link Frequency Relevance Heat
Breast Cancer 1505 99.84 Very High Very High Very High
Psoriasis 70 99.84 Very High Very High Very High
Malignant Neoplastic Disease 35 99.84 Very High Very High Very High
Cancer 1120 99.52 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 175 99.48 Very High Very High Very High
Necrosis 35 98.76 Very High Very High Very High
Metastasis 630 98.68 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 70 98.32 Very High Very High Very High
Osteolysis 35 98.32 Very High Very High Very High
INFLAMMATION 70 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High VEGF levels have been detected in S100A7-overexpressing cells and these levels were correlated with increased tumor angiogenesis in human breast tumors [14].
Gene_expression (-) of S100A7 associated with cancer and breast cancer
1) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.57 Pain Relevance 0
Calbindin D-28K and S-100-like molecules were detected in gill epithelium, and their expression appeared enhanced after lead exposure.
Gene_expression (detected) of S-100-like in epithelium
2) Confidence 0.13 Published 1999 Journal Histochem. J. Section Abstract Doc Link 10507463 Disease Relevance 0.15 Pain Relevance 0.35
MDA-MB-468 cells (S100A7-expressing control cells and S100A7-downregulated cells) were grown to 70% confluence, and the culture medium was changed to that without antibiotics 24 hours prior to harvesting.
Gene_expression (-) of S100A7 in MDA-MB-468
3) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.38 Pain Relevance 0
We have found that epidermal growth factor regulates S100A7 expression.
Gene_expression (expression) of S100A7
4) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.62 Pain Relevance 0.03
The results are in agreement with previous studies which reported a 1.4-fold increase in invasiveness in S100A7-overexpressing MDA-MB-231 clones [28].
Gene_expression (overexpressing) of S100A7 in MDA-MB-231
5) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.78 Pain Relevance 0.03
S100A7-Downregulation Inhibits Epidermal Growth Factor-Induced Signaling in Breast Cancer Cells and Blocks Osteoclast Formation

S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and breast.

Gene_expression (expressed) of S100A7 in skin associated with psoriasis, basal and squamous cell skin cancer and breast cancer
6) Confidence 0.12 Published 2008 Journal PLoS ONE Section Title Doc Link PMC2254193 Disease Relevance 0.56 Pain Relevance 0
Recent studies have suggested that EGF may regulate S100A7 expression [8].
Gene_expression (expression) of S100A7
7) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.74 Pain Relevance 0.03
It has been shown that S100A7 overexpression increases VEGF expression levels (8) and that downregulation of S100A7 decreases the expression of VEGF [14].
Gene_expression (overexpression) of S100A7
8) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.23 Pain Relevance 0
It has been shown that downregulation of S100A7 expression markedly decreases in vivo tumorigenicity and lung metastasis [14].
Gene_expression (expression) of S100A7 in lung associated with metastasis
9) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.78 Pain Relevance 0
Here, we showed for the first time that epidermal growth factor (EGF) induces S100A7 expression in both MCF-7 and MDA-MB-468 cell lines.
Gene_expression (expression) of S100A7 in MDA-MB-468
10) Confidence 0.12 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2254193 Disease Relevance 0.34 Pain Relevance 0
Persistent S100A7 expression also occurs in a subset of invasive breast carcinomas and is linked to worse clinical outcome [26].
Gene_expression (expression) of S100A7 associated with breast cancer
11) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.03 Pain Relevance 0.04
EGF increased the expression of S100A7 in a dose-dependent manner in both MCF-7 cells (Figure 1A) and MDA-MB-468 cells (Figure 1B).
Gene_expression (expression) of S100A7 in MDA-MB-468
12) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.32 Pain Relevance 0
The high expression level of S100A7 in poorly differentiated and lymph node positive breast tumors suggests that it may predict poor clinical outcome and a high risk of recurrence or progression in DCIS [7].
Gene_expression (expression) of S100A7 in lymph node associated with breast cancer, noninfiltrating intraductal carcinoma and recurrence
13) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.55 Pain Relevance 0.04
In addition, a correlation was observed between high S100A7 expression and the angiogenic marker CD31 in samples derived from human breast cancer [14].
Gene_expression (expression) of S100A7 associated with breast cancer
14) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.25 Pain Relevance 0
Single suspensions of cells expressing S100A7 (vector control) or S100A7-downregulated cells were harvested from the subconfluent cultures by exposure to 0.25% trypsin and 0.02% EDTA.
Gene_expression (expressing) of S100A7
15) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.31 Pain Relevance 0
The S100A7 protein is known to be expressed in various tumors having squamous differentiation as a major component with or without accompanying inflammation (eg, squamous cell carcinoma of the skin [2], [3], lung [4], cervix, bladder [5] and breast as well as adenocarcinoma of the breast [6].
Gene_expression (expressed) of S100A7 protein in cervix associated with adenocarcinoma, inflammation, basal and squamous cell skin cancer and cancer
16) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.96 Pain Relevance 0.05
Our in vivo findings concur with a previous study which reported that S100A7-downregulated tumors have reduced VEGF expression in vitro as compared to vector-transfected control cells, and that human breast cancer tissues with decreased S100A7 expression levels have reduced CD31 staining [14].
Gene_expression (expression) of S100A7 associated with cancer and breast cancer
17) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.90 Pain Relevance 0
Growth factors regulate S100A7 expression
Gene_expression (expression) of S100A7
18) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.55 Pain Relevance 0
S100A7 has been shown to be overexpressed in breast cancers at sites of necrosis in tumor tissues [6], [8], as well as in the nasal fluid during allergic inflammatory reactions [27].
Gene_expression (overexpressed) of S100A7 in nasal associated with necrosis, inflammation, cancer, hypersensitivity and breast cancer
19) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.09 Pain Relevance 0.05
Loss of S100A7 expression alters the phosphorylation state of receptors and inhibits growth factor-induced cell motility and invasion on fibronectin-coated plates and matrigel-coated chambers.
Gene_expression (expression) of S100A7
20) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.59 Pain Relevance 0.03

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