INT84375

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 8.75
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
chondrocytes 1
ligaments 1
osteoblast 1
skeleton 1
skin 1
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
acular 3 100.00 Very High Very High Very High
cINOD 7 94.92 High High
rheumatoid arthritis 4 92.96 High High
Arthritis 4 87.36 High High
Osteoarthritis 108 84.64 Quite High
Pain 10 62.56 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenesis Imperfecta 16 99.96 Very High Very High Very High
Osteoporosis 8 99.52 Very High Very High Very High
Obesity 208 99.48 Very High Very High Very High
Hand Deformities 16 95.36 Very High Very High Very High
Rheumatoid Arthritis 4 92.96 High High
Overweight 26 92.80 High High
Arthritis 6 87.36 High High
Osteoarthritis 108 84.64 Quite High
Congenital Anomalies 4 83.56 Quite High
INFLAMMATION 16 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OI, affecting the type I collagen tissue of the sclera, skin, ligaments, and skeleton, presenting with ligament laxity resulting in subluxations and hand deformities may be misdiagnosed as hand deformities of rheumatoid arthritis.
Regulation (affecting) of type I collagen in skeleton associated with hand deformities, osteogenesis imperfecta and rheumatoid arthritis
1) Confidence 0.44 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15856364 Disease Relevance 1.63 Pain Relevance 0.21
OI, affecting the type I collagen tissue of the sclera, skin, ligaments, and skeleton, presenting with ligament laxity resulting in subluxations and hand deformities may be misdiagnosed as hand deformities of rheumatoid arthritis.
Regulation (affecting) of type I collagen in ligaments associated with hand deformities, osteogenesis imperfecta and rheumatoid arthritis
2) Confidence 0.15 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15856364 Disease Relevance 1.63 Pain Relevance 0.21
OI, affecting the type I collagen tissue of the sclera, skin, ligaments, and skeleton, presenting with ligament laxity resulting in subluxations and hand deformities may be misdiagnosed as hand deformities of rheumatoid arthritis.
Regulation (affecting) of type I collagen in sclera associated with hand deformities, osteogenesis imperfecta and rheumatoid arthritis
3) Confidence 0.15 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15856364 Disease Relevance 1.63 Pain Relevance 0.21
OI, affecting the type I collagen tissue of the sclera, skin, ligaments, and skeleton, presenting with ligament laxity resulting in subluxations and hand deformities may be misdiagnosed as hand deformities of rheumatoid arthritis.
Regulation (affecting) of type I collagen in skin associated with hand deformities, osteogenesis imperfecta and rheumatoid arthritis
4) Confidence 0.15 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15856364 Disease Relevance 1.63 Pain Relevance 0.21
The most striking effects of leptin in obese patients, that is the up-regulation of IGF-1, collagen type 2 and MMP-13, were found with the highest concentration of leptin.
Regulation (regulation) of collagen type 2 associated with obesity
5) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.98 Pain Relevance 0.06
The effects of PGE1 and PGE2, indomethacin, and ketorolac on thymidine incorporation, cell count, intracellular alkaline phosphatase (ALP) activity, and Type I collagen content in osteoblast-enriched cultures derived from fetal calvaria were evaluated.
Regulation (effects) of Type I collagen in osteoblast associated with acular and osteoporosis
6) Confidence 0.07 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10509750 Disease Relevance 0.40 Pain Relevance 0.74
By contrast, the highest concentration of leptin was required to up-regulate type 2 collagen in chondrocytes isolated from obese patients (Figure 2).
Regulation (regulate) of type 2 collagen in chondrocytes associated with obesity
7) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.85 Pain Relevance 0.08

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