INT84390

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.82
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
neuronal 2
neurons 1
skin 1
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 8 98.44 Very High Very High Very High
fluoxetine 5 97.80 Very High Very High Very High
cerebral cortex 3 96.00 Very High Very High Very High
Inflammation 26 94.24 High High
Spinal cord 18 94.12 High High
Nerve growth factor 4 93.24 High High
Morphine 5 90.56 High High
Kinase C 3 88.00 High High
Inflammatory response 12 87.60 High High
ischemia 50 84.72 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 1 98.84 Very High Very High Very High
INFLAMMATION 38 94.24 High High
Death 18 88.80 High High
Pheochromocytoma 1 87.56 High High
Stress 22 86.64 High High
Cv Unclassified Under Development 46 84.72 Quite High
Toxicity 10 79.36 Quite High
Injury 37 78.92 Quite High
Brain Hemorrhage 3 75.00 Quite High
Ganglion Cysts 9 57.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we show that long-term elevation of intracellular cAMP levels in rat primary cortical cultures results in a persistent downregulation of GAP-43 and neurogranin, most likely at the transcriptional level.
Spec (likely) Negative_regulation (downregulation) of GAP-43
1) Confidence 0.58 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 18005072 Disease Relevance 0 Pain Relevance 0.19
In the CA3 region a reduction of GAP-43 mRNA was observed after treatment with imipramine (21 days) and fluoxetine (7 and 14 days).
Negative_regulation (reduction) of GAP-43 mRNA associated with fluoxetine
2) Confidence 0.55 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.71
Intraepidermal labelling of GAP-43 peptide was observed in the skin of control animals, but was markedly reduced in the animals that were treated with capsaicin alone.
Negative_regulation (reduced) of GAP-43 peptide in skin associated with qutenza
3) Confidence 0.43 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10511462 Disease Relevance 0 Pain Relevance 0.66
Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.
Negative_regulation (downregulated) of Gap43 associated with aids-related complex
4) Confidence 0.41 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.39
LPS resulted in increased expression of a number of regenerative associated genes (e.g., Gap-43, Scg10, and Chl1) in CST neurons, although this regenerative response did not contribute to sprouting or regeneration of CST axons damaged in the spinal cord at the time of LPS application [48].
Negative_regulation (number) of Gap-43 in neurons associated with spinal cord
5) Confidence 0.22 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.88 Pain Relevance 0.48
Our most striking finding was that the decrease in acute microglial activation induced by 3-AB was associated with a long term down-regulation of two neuronal plasticity proteins expression, synaptophysin (marker of synaptogenesis) and GAP-43 (marker of neuritogenesis) as well as to a significant decrease in tissue BDNF production.
Negative_regulation (regulation) of GAP-43 in neuronal
6) Confidence 0.16 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779656 Disease Relevance 0.33 Pain Relevance 0.14
Also, the level of the GAP43 protein, a marker for neuronal differentiation, was decreased.
Negative_regulation (decreased) of GAP43 protein in neuronal
7) Confidence 0.01 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC3016300 Disease Relevance 0.50 Pain Relevance 0.05

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