INT84392

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.98
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdc) lyase activity (Hdc) cellular amino acid metabolic process (Hdc)
Anatomy Link Frequency
mast cell 1
Hdc (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 91.44 High High
Pain 1 89.60 High High
Inflammation 1 88.88 High High
antagonist 2 50.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 100.00 Very High Very High Very High
Fistula 2 94.16 High High
Mastocytoma 1 93.24 High High
Pain 1 89.60 High High
Pressure And Volume Under Development 1 89.24 High High
INFLAMMATION 1 88.88 High High
Cv General 2 Under Development 1 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present work investigated the role of endogenous histamine in carbachol- and gastrin-induced gastric acid secretion with HDC-knockout (HDC-/-) mice.
Localization (secretion) of HDC-knockout associated with targeted disruption
1) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12893847 Disease Relevance 0.27 Pain Relevance 0.09
In the rat mast cell line, the endogenous 74 kDa form of HDC was translated in the cytosol and then translocated to the ER, where it was post-translationally processed to the 53 kDa form.
Localization (translocated) of HDC in mast cell
2) Confidence 0.68 Published 1999 Journal Yakugaku Zasshi Section Abstract Doc Link 10511817 Disease Relevance 0.44 Pain Relevance 0.13
The present work investigated the role of endogenous histamine in carbachol- and gastrin-induced gastric acid secretion with HDC-knockout (HDC-/-) mice.
Localization (secretion) of HDC associated with targeted disruption
3) Confidence 0.61 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12893847 Disease Relevance 0.27 Pain Relevance 0.12

General Comments

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