INT84396

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Context Info
Confidence 0.24
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Anatomy Link Frequency
plasma 2
hepatocytes 2
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
carbamazepine 2 98.80 Very High Very High Very High
fluoxetine 1 98.44 Very High Very High Very High
alcohol 3 95.04 Very High Very High Very High
sSRI 1 61.12 Quite High
tricyclic antidepressant 1 59.36 Quite High
headache 6 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 3 99.52 Very High Very High Very High
Toxicity 1 46.40 Quite Low
Schizophrenia 2 44.36 Quite Low
Cirrhosis 1 17.04 Low Low
Chronic Renal Failure 1 9.56 Low Low
Hypersomnia 87 5.00 Very Low Very Low Very Low
Sleep Disorders 53 5.00 Very Low Very Low Very Low
Apnoea 44 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low
Anxiety 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluvoxamine, an inhibitor of CYP1A2, increases plasma concentrations of olanzapine; inducers of CYP1A2, including tobacco smoke and carbamazepine, decrease olanzapine concentrations.
Positive_regulation (increases) of Positive_regulation (inducers) of CYP1A2 in plasma associated with nicotine addiction and carbamazepine
1) Confidence 0.24 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10511917 Disease Relevance 0.22 Pain Relevance 0.28
Modafinil also has been shown to cause a modest induction of CYP3A4, CYP2B6, and CYP1A2 in human hepatocytes (Robertson et al 2000).
Positive_regulation (cause) of Positive_regulation (induction) of CYP1A2 in hepatocytes
2) Confidence 0.22 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 0 Pain Relevance 0.06

General Comments

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