INT84427

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Context Info
Confidence 0.64
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.05
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TSPO) mitochondrion (TSPO) aging (TSPO)
response to stress (TSPO)
Anatomy Link Frequency
brains 2
thalamus 2
T cells 2
TSPO (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 128 100.00 Very High Very High Very High
cINOD 33 100.00 Very High Very High Very High
Paracetamol 28 100.00 Very High Very High Very High
Analgesic 17 100.00 Very High Very High Very High
gABA 5 99.16 Very High Very High Very High
carbamazepine 32 98.82 Very High Very High Very High
Thalamus 6 97.80 Very High Very High Very High
fibrosis 74 94.12 High High
agonist 6 90.88 High High
local anesthetic 1 86.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 67 100.00 Very High Very High Very High
Bladder Disease 34 100.00 Very High Very High Very High
Breast Cancer 4 99.36 Very High Very High Very High
Partial Seizures 1 99.20 Very High Very High Very High
Ulcers 8 97.64 Very High Very High Very High
Generalized Epilepsy 4 97.20 Very High Very High Very High
Cancer 52 96.28 Very High Very High Very High
Cardiovascular Disorder Under Development 56 94.12 High High
Alzheimer's Dementia 170 93.24 High High
Amyloid Plaque 32 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In breast carcinoma an increase in expression of peripheral-type benzodiazepine receptors (PBR) and the gamma aminobutyl acid (GABA) level has been discovered.
Positive_regulation (increase) of Gene_expression (expression) of PBR associated with gaba
1) Confidence 0.64 Published 2002 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 12139540 Disease Relevance 0.27 Pain Relevance 0.44
Fig. 1Removal, during MBR and CAS treatment, of the analgesics and anti-inflammatory drugs naproxen (a), ketoprofen (b), ibuprofen (c), mefenamic acid (d), diclofenac (e), indomethacin (f), acetaminophen (g), and propyphenazone (h)Fig. 2Removal during MBR and CAS treatment of the antibiotics ofloxacin (a), sulfamethoxazole (b), and erythromycin (c), the ?
Positive_regulation (during) of Gene_expression (treatment) of MBR associated with paracetamol, inflammation, analgesic, cinod and diclofenac
2) Confidence 0.40 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0.17 Pain Relevance 0.37
Fig. 1Removal, during MBR and CAS treatment, of the analgesics and anti-inflammatory drugs naproxen (a), ketoprofen (b), ibuprofen (c), mefenamic acid (d), diclofenac (e), indomethacin (f), acetaminophen (g), and propyphenazone (h)Fig. 2Removal during MBR and CAS treatment of the antibiotics ofloxacin (a), sulfamethoxazole (b), and erythromycin (c), the ?
Positive_regulation (during) of Gene_expression (treatment) of MBR associated with paracetamol, inflammation, analgesic, cinod and diclofenac
3) Confidence 0.40 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0.24 Pain Relevance 0.49
Fig. 1Removal, during MBR and CAS treatment, of the analgesics and anti-inflammatory drugs naproxen (a), ketoprofen (b), ibuprofen (c), mefenamic acid (d), diclofenac (e), indomethacin (f), acetaminophen (g), and propyphenazone (h)Fig. 2Removal during MBR and CAS treatment of the antibiotics ofloxacin (a), sulfamethoxazole (b), and erythromycin (c), the ?
Positive_regulation (during) of Gene_expression (treatment) of MBR associated with paracetamol, inflammation, analgesic, cinod and diclofenac
4) Confidence 0.40 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0.24 Pain Relevance 0.49
-blockers atenolol (d) and metoprolol (e), the anti-ulcer agent ranitidine (f), the antiepileptic drug carbamazepine (g), and the psychiatric drug paroxetine (h)Fig. 3Removal during MBR and CAS treatment of the lipid regulator and cholesterol-lowering statin drugs gemfibrozil (a), bezafibrate (b), clofibric acid (c), and pravastatin (d), the diuretic hydrochlorothiazide (e), and the hypoglycaemic agent glibenclamide (f)
Positive_regulation (during) of Gene_expression (treatment) of MBR associated with ulcers and carbamazepine
5) Confidence 0.40 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0.26 Pain Relevance 0.60
Australia's senior negotiator on the AUSFTA PBS provisions, likewise stated:
Positive_regulation (negotiator) of Gene_expression (provisions) of PBS
6) Confidence 0.35 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1894805 Disease Relevance 0 Pain Relevance 0
Also observed was increased benzodiazepine receptor density in the cerebellar nuclei and decreased density in the thalamus.
Positive_regulation (increased) of Gene_expression (density) of benzodiazepine receptor in thalamus associated with thalamus
7) Confidence 0.30 Published 1999 Journal Adv Neurol Section Abstract Doc Link 10514872 Disease Relevance 0.72 Pain Relevance 0.45
Although these findings clearly indicate that the IBP can overestimate IAP when large volumes of saline are infused, the possible mechanisms involved are still not clearly understood.
Positive_regulation (overestimate) of Gene_expression (overestimate) of IBP
8) Confidence 0.28 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.45 Pain Relevance 0
The PBS expenditure on biologicals increased steadily over the study period (Figure 3).
Positive_regulation (increased) of Gene_expression (expenditure) of PBS
9) Confidence 0.24 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1828161 Disease Relevance 0.20 Pain Relevance 0.13
The myelin stained fibres also showed a two-fold increase in the PBS and IDO groups, but this was not statistically significant (PBS, P = 0.143, IDO, P = 0.076; Fig 3d).
Positive_regulation (increase) of Gene_expression (groups) of PBS associated with bladder disease
10) Confidence 0.07 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.81 Pain Relevance 0.22
Purified murine or human CD8+ and CD4+ T cells were stimulated three times per day for 2 days with either PBS or ?
Positive_regulation (stimulated) of Gene_expression (days) of PBS in T cells
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.26 Pain Relevance 0.03
g at 4°C for 5 minutes, washed once with PBS, and finally resuspended in 50?
Positive_regulation (once) of Gene_expression (washed) of PBS
12) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0 Pain Relevance 0.08
At the latest treatment interval analyzed by ELISA, animals administered dox for 6 mo showed elevated levels of PBS-soluble A?
Positive_regulation (elevated) of Gene_expression (levels) of PBS
13) Confidence 0.02 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.39 Pain Relevance 0
After 48 h in fixative at 4 °C, brains were transferred to PBS, dehydrated in alcohols, treated with cedarwood oil and methylsalicylate, and embedded in paraffin for sectioning.
Positive_regulation (transferred) of Gene_expression (transferred) of PBS in brains
14) Confidence 0.02 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.16 Pain Relevance 0
mice, which had increased basal expression of these genes (PBS infusion, Fig. 2E and F).
Positive_regulation (ch had in) of Gene_expression ( basal exp) of PBS
15) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.89 Pain Relevance 0.27

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