INT84463

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.81
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4)
Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)
Anatomy Link Frequency
blood 2
fibroblasts 2
brush 2
DPP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.44 Very High Very High Very High
chemokine 31 95.24 Very High Very High Very High
cytokine 28 89.12 High High
Inflammation 19 86.28 High High
abdominal pain 2 67.76 Quite High
Arthritis 44 60.72 Quite High
metalloproteinase 4 59.92 Quite High
rheumatoid arthritis 22 54.88 Quite High
antagonist 2 47.92 Quite Low
Analgesic 1 41.16 Quite Low
Disease Link Frequency Relevance Heat
Cancer 142 99.04 Very High Very High Very High
Renal Cancer 78 98.60 Very High Very High Very High
Carcinoma 8 96.20 Very High Very High Very High
Nephrotoxicity 1 96.04 Very High Very High Very High
Renal Disease 8 95.32 Very High Very High Very High
Metastasis 2 93.60 High High
Colon Cancer 54 93.48 High High
Polyps 32 91.12 High High
Cleidocranial Dysplasia 10 89.72 High High
Malignant Neoplastic Disease 11 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the present manuscript shows that the modifications affecting DPP IV and NEP profiles along the different phenotypes of renal cancer are similar to those we observed in our previous studies on other membrane-bound peptidases, such as IRAP, APN and APA [12,13,28], and thus reinforces the idea that loss of several physiologically significant glycopeptidases may be a critical step in the etiogenesis of renal tumors.
Regulation (affecting) of Gene_expression (profiles) of DPP IV associated with renal cancer
1) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.91 Pain Relevance 0.03
Changes were not significant for DPP IV (Figure 3A) nor NEP expression (Figure 3B) in CCRCC and RO tumors when compared with their corresponding normal tissues.
Neg (not) Regulation (significant) of Gene_expression (expression) of DPP IV associated with cancer
2) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.65 Pain Relevance 0
Collection of blood samples and determination of the sCD26 levels
Regulation (determination) of Gene_expression (levels) of sCD26 in blood
3) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912863 Disease Relevance 2.06 Pain Relevance 0.15
the regulation of CD26/DPP IV expression in fibroblasts is rather controversial [20,21].
Regulation (regulation) of Gene_expression (expression) of CD26/DPP IV in fibroblasts
4) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.32 Pain Relevance 0.37
This study has shown that urinary excretion of APN, DPP IV, NAGA and GGT, as markers of kidney brush border and lysosomal damage, did not change after 2 g of acetaminophen taken orally. beta 2-microglobulin was a marker of acute acetaminophen nephrotoxicity in kidney disease patients and in clinically healthy adults from nephropathic families.
Neg (not) Regulation (change) of Gene_expression (excretion) of DPP IV in brush associated with nephrotoxicity, paracetamol and renal disease
5) Confidence 0.04 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.87 Pain Relevance 0.78

General Comments

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