INT84464

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 101
Total Number 101
Disease Relevance 56.15
Pain Relevance 17.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4)
Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)
Anatomy Link Frequency
fibroblasts 18
T cell 7
kidney 3
plasma 2
adrenal gland 2
DPP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 740 100.00 Very High Very High Very High
adenocard 10 99.92 Very High Very High Very High
cytokine 713 99.70 Very High Very High Very High
Inflammation 571 99.62 Very High Very High Very High
substance P 36 99.18 Very High Very High Very High
rheumatoid arthritis 551 98.58 Very High Very High Very High
Central nervous system 30 98.56 Very High Very High Very High
spinal inflammation 457 98.42 Very High Very High Very High
metalloproteinase 78 98.08 Very High Very High Very High
Arthritis 1059 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Cancer 936 99.84 Very High Very High Very High
Cancer 1720 99.80 Very High Very High Very High
Weight Loss 107 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 22 99.64 Very High Very High Very High
INFLAMMATION 557 99.62 Very High Very High Very High
Renal Cell Carcinoma 24 99.56 Very High Very High Very High
Diabetes Mellitus 1525 99.48 Very High Very High Very High
Appetite Loss 7 99.40 Very High Very High Very High
Colon Cancer 540 99.20 Very High Very High Very High
Fatigue 233 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results agree with previous studies indicating that modifications in the activity and expression profiles of DPP IV and NEP are key events in malignant tumors, pointing to an involvement of these proteins in tumor cell growth, local invasion and metastasis [7,25-27]; and, in addition, this study extend that role of both peptidases to the renal tumors.
Gene_expression (expression) of DPP IV associated with malignant neoplastic disease, cancer, renal cancer and metastasis
1) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.84 Pain Relevance 0
With respect to the relationship between DPP IV expression and cancer, the unique example of a clear causal effect is seen in human melanocytes where the loss of DPP IV is invariably associated with malignant transformation [35].
Gene_expression (expression) of DPP IV in melanocytes associated with malignant neoplastic disease and cancer
2) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 1.02 Pain Relevance 0.03
Thus, DPP IV relative expression (Figure 3A) decreased fortysixfold in chromophobe RCCs, whereas NEP mRNA levels (Figure 3B) decreased sixtysevenfold in the same tumor-type.
Gene_expression (expression) of DPP IV associated with cancer and renal cancer
3) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.66 Pain Relevance 0
Thus, as shown in Figure 3A, DPP IV expression did not change in CCRCC, and it decreased twofold in RO.
Gene_expression (expression) of DPP IV
4) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.57 Pain Relevance 0
Quantitation of DPP IV and NEP mRNA expression
Gene_expression (expression) of DPP IV
5) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.15 Pain Relevance 0
Quantitative DPP IV and NEP expression profile in renal tumors
Gene_expression (expression) of DPP IV associated with renal cancer
6) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.42 Pain Relevance 0
The expression of the housekeeping genes, DPP4 and MME was quantified in all cDNAs by real-time PCR using the iCycler iQ real-time detection apparatus (BioRad Laboratories, Hercules, CA, USA).
Gene_expression (expression) of DPP4
7) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.15 Pain Relevance 0
The inverse relationship suggested that products of the inflammatory process inhibited DPP IV expression.
Gene_expression (expression) of DPP IV associated with inflammation
8) Confidence 0.73 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.43 Pain Relevance 0.13
DPP IV is also known as CD26, and is highly expressed on memory T cells [43].
Gene_expression (expressed) of DPP IV in memory T cells
9) Confidence 0.73 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.43 Pain Relevance 0.13
Changes were not significant for DPP IV (Figure 3A) nor NEP expression (Figure 3B) in CCRCC and RO tumors when compared with their corresponding normal tissues.
Gene_expression (expression) of DPP IV associated with cancer
10) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.64 Pain Relevance 0
Statistical analyses of grading for cell surface DPP IV (DPP IV/CD26) and staging for both soluble and membrane-bound DPP IV activities were not significant.
Gene_expression (activities) of DPP IV
11) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.32 Pain Relevance 0
Quantitation of DPP IV and NEP Catalytic Activity
Gene_expression (Quantitation) of DPP IV
12) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.33 Pain Relevance 0
 ; low vs high stage) and membrane-bound DPP IV (19%?
Gene_expression (stage) of DPP IV
13) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.73 Pain Relevance 0
CALLA: (common acute lymphoblastic leukemia antigen); CCRCC: (clear-cell renal cell carcinoma); ChRCC: (chromophobe renal cell carcinoma); DPPIV: (dipeptidyl peptidase IV); NEP: (neprilysine, neutral endopeptidase); RO: (renal oncocytoma); UP: (Units of Peptidase, pmol of product/min).


Gene_expression (neprilysine) of peptidase IV associated with leukemia, renal cancer, renal cell carcinoma and oxyphilic adenoma
14) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 1.16 Pain Relevance 0
When the levels of sCD26 were compared among all the five groups of patients, we found significant differences (Kruskal-Wallis test p < 0.001).
Gene_expression (levels) of sCD26
15) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912863 Disease Relevance 1.66 Pain Relevance 0.06
It could be demonstrated that DPP-4 inhibition increases circulating levels of GLP-1 in experimental animals and that the insulinotropic action of exogenously administered GLP-1 is intensified by DPP-4 inhibition (Holst and Deacon 1998).
Neg (inhibition) Gene_expression (inhibition) of DPP-4
16) Confidence 0.66 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.20 Pain Relevance 0
Substance P - induced vasodilation was augmented by DPP IV inhibition in an in vivo porcine nasal model [6,8].
Neg (inhibition) Gene_expression (inhibition) of DPP IV in nasal associated with increased venous pressure under development and substance p
17) Confidence 0.63 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.55 Pain Relevance 0.50
The DPP-4 enzyme (also referred to as the protein CD26) is expressed on activated T cells, and, although the role of DPP-4 enzyme activity in T cell function is not clear, it is unlikely related to the co-stimulatory function of CD26 [21,22].
Gene_expression (expressed) of DPP-4 enzyme in T cell
18) Confidence 0.62 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2605739 Disease Relevance 0.84 Pain Relevance 0.18
Thus, the relative expression of DPP4 (DPP IV transcriptome) and MME (NEP transcriptome) genes were found to be strongly decreased in ChRCC samples (DPP IV: ?
Gene_expression (expression) of DPP IV
19) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.51 Pain Relevance 0
Quantitative RT-PCR for detecting DPP IV and NEP mRNA (DPP4 and MME genes respectively) was performed to assess the transcription levels of these peptidases.
Gene_expression (detecting) of DPP IV
20) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.16 Pain Relevance 0

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