INT84465

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 7.28
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4)
Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)
Anatomy Link Frequency
hepatocytes 1
brush 1
T cell 1
DPP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 19 99.72 Very High Very High Very High
Paracetamol 22 99.52 Very High Very High Very High
bradykinin 5 96.32 Very High Very High Very High
Neuropeptide 6 95.76 Very High Very High Very High
substance P 5 94.88 High High
adenocard 1 82.48 Quite High
Calcitonin gene-related peptide 3 81.52 Quite High
medulla 1 72.36 Quite High
cytokine 9 71.28 Quite High
calcitonin gene related peptide 1 56.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 16 99.72 Very High Very High Very High
Cancer 78 99.68 Very High Very High Very High
Polyps 32 99.32 Very High Very High Very High
Choroideremia 166 98.64 Very High Very High Very High
Disease Progression 2 98.24 Very High Very High Very High
Balkan Nephropathy 12 96.84 Very High Very High Very High
Renal Disease 25 96.52 Very High Very High Very High
Pressure And Volume Under Development 2 95.64 Very High Very High Very High
Obesity 18 95.10 Very High Very High Very High
Hypoglycemia 21 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DPP IV and NEP activities were markedly decreased in all tumor subtypes, and protein and mRNAs were strongly down-regulated in ChRCC and RO.
Localization (decreased) of DPP IV associated with cancer
1) Confidence 0.75 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.84 Pain Relevance 0
Native GLP-1 is, however, rapidly metabolized by enzymes such as dipeptidyl peptidase-IV (DPP-IV), giving it a very short half-life (t1/2 < 2 min) [5, 15] and limiting its potential to be deployed as a therapeutic agent [10].
Localization (metabolized) of dipeptidyl peptidase-IV
2) Confidence 0.73 Published 2010 Journal British Journal of Clinical Pharmacology Section Body Doc Link PMC2997321 Disease Relevance 0.88 Pain Relevance 0
DPP IV can cleave substrates such as eotaxin, regulated on activation normal T cell expressed and secreted (RANTES, CCL5), neuropeptide Y (NPY), substance P, chromogranin B - derived peptides, and other airway peptides [32,33].
Localization (cleave) of DPP IV in T cell associated with neuropeptide and substance p
3) Confidence 0.70 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.46 Pain Relevance 0.62
We analysed the relationship of the sCD26 with the histopathological characteristics of the colorectal polyps found by colonoscopy (table 3), including: number of polyps (1-2, 3 or more); size (?
Spec (analysed) Localization (relationship) of sCD26 associated with polyps
4) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912863 Disease Relevance 1.37 Pain Relevance 0
Administration of metformin to obese subjects was also found to increase levels of active GLP-1 after a glucose load: this phenomenon appears to occur through mechanisms other than DPP-4 inhibition, and may instead be due to direct stimulation of GLP-1 secretion or a reduction in DPP-4 secretion (Mannucci et al 2001; Lenhard et al 2004).
Localization (secretion) of DPP-4 associated with obesity
5) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597758 Disease Relevance 0.24 Pain Relevance 0.04
Native GLP-1 is, however, rapidly metabolized by enzymes such as dipeptidyl peptidase-IV (DPP-IV), giving it a very short half-life (t1/2 < 2 min) [5, 15] and limiting its potential to be deployed as a therapeutic agent [10].
Localization (metabolized) of DPP-IV
6) Confidence 0.39 Published 2010 Journal British Journal of Clinical Pharmacology Section Body Doc Link PMC2997321 Disease Relevance 0.88 Pain Relevance 0
RESULTS: P-gp and the canalicular marker protein dipeptidyl peptidase IV (DPPIV) co-localized by Day 3 and Day 6 in SC rat hepatocytes and SC human hepatocytes, respectively, consistent with canalicular network formation visualized by light microscopy.
Localization (localized) of peptidase IV in hepatocytes
7) Confidence 0.21 Published 2004 Journal Pharm. Res. Section Body Doc Link 15290872 Disease Relevance 0 Pain Relevance 0
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Localization (secreted) of DPP4 associated with choroideremia
8) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.76 Pain Relevance 0.06
After acetaminophen administration urinary excretion of APN, dipeptidylpeptidase IV (DPP IV), gamma-glutamyltranspeptidase (GGT) and N-acetyl-beta-D-glucosaminidase (NAGA) did not increase significantly in any group studied.
Localization (excretion) of DPP IV associated with paracetamol
9) Confidence 0.07 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.98 Pain Relevance 0.79
This study has shown that urinary excretion of APN, DPP IV, NAGA and GGT, as markers of kidney brush border and lysosomal damage, did not change after 2 g of acetaminophen taken orally. beta 2-microglobulin was a marker of acute acetaminophen nephrotoxicity in kidney disease patients and in clinically healthy adults from nephropathic families.
Localization (excretion) of DPP IV in brush associated with nephrotoxicity, paracetamol and renal disease
10) Confidence 0.07 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.87 Pain Relevance 0.77

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