INT84473

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.21
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SARDH) oxidoreductase activity (SARDH) biological_process (SARDH)
cytoplasm (SARDH)
Anatomy Link Frequency
hair 2
body 2
nerve 1
SARDH (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 22 100.00 Very High Very High Very High
substance P 13 100.00 Very High Very High Very High
intrathecal 1 100.00 Very High Very High Very High
imagery 126 99.78 Very High Very High Very High
agonist 1 99.24 Very High Very High Very High
Eae 6 98.84 Very High Very High Very High
Sciatic nerve 1 93.08 High High
Neuropathic pain 4 89.04 High High
antagonist 3 85.60 High High
Central nervous system 1 79.72 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 1 100.00 Very High Very High Very High
Injury 10 98.84 Very High Very High Very High
Hypersensitivity 1 95.64 Very High Very High Very High
Neuropathic Pain 4 89.04 High High
Nociception 1 77.56 Quite High
Alopecia 2 69.20 Quite High
Reflex Epilepsy 3 24.56 Low Low
Convulsion 3 22.60 Low Low
Body Temperature Changes 3 11.16 Low Low
Vomiting 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In one subject, BPR and NBPR were not detected in any hair segment.
Neg (not) Gene_expression (detected) of BPR in hair associated with buprenorphine
1) Confidence 0.77 Published 1999 Journal J Anal Toxicol Section Abstract Doc Link 10517544 Disease Relevance 0.07 Pain Relevance 0.72
In some subjects, BPR and NBPR were detected in hair segments that did not correspond to the period of drug treatment, suggesting that drug movement may have occurred by diffusion in sweat and other mechanisms.
Gene_expression (detected) of BPR in hair associated with buprenorphine
2) Confidence 0.67 Published 1999 Journal J Anal Toxicol Section Abstract Doc Link 10517544 Disease Relevance 0.07 Pain Relevance 0.72
Synthesis, SAR, and improvements in metabolic stability and absorption of these compounds are described herein.
Gene_expression (Synthesis) of SAR
3) Confidence 0.23 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 18299195 Disease Relevance 0 Pain Relevance 0.04
However, in terms of safety, it would be desirable that a clinical MR system be equipped with a sensing phantom that could shut off the power to the RF source when SAR levels approach the limits established by international safety guidelines.
Gene_expression (levels) of SAR
4) Confidence 0.18 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419710 Disease Relevance 0 Pain Relevance 0.29
A study [88] measured the scrotal skin temperatures in volunteers exposed to an MRI procedure at whole-body averaged SAR of 1.1 W/kg.
Gene_expression (averaged) of SAR in body associated with imagery
5) Confidence 0.16 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419710 Disease Relevance 0 Pain Relevance 0.09
In MRI exams, an SAR of 8 W/kg could be used, but for short enough exposures so as not to produce a more than 1°C core body temperature rise.
Gene_expression (used) of SAR in body associated with imagery
6) Confidence 0.16 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419710 Disease Relevance 0 Pain Relevance 0.35
Intraplantar injections of SP and the selective NK-1 receptor agonist, [Sar(9)-Met(O(2))(11)]-substance P (Sar-SP), to the paw ipsilateral to the nerve injury and intrathecal administration of these peptides produced paw-lifting behavior in the CCI gerbils in thermoneutral conditions.
Gene_expression (produced) of Sar-SP in nerve associated with nervous system injury, eae, agonist, intrathecal and substance p
7) Confidence 0.01 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 13679213 Disease Relevance 1.08 Pain Relevance 1.18

General Comments

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