INT84494

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 44
Total Number 51
Disease Relevance 22.34
Pain Relevance 28.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 14
spinal 8
amygdala 6
spinal cord 4
dorsal horn 4
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 590 100.00 Very High Very High Very High
amygdala 440 100.00 Very High Very High Very High
Spinal cord 192 100.00 Very High Very High Very High
intrathecal 79 100.00 Very High Very High Very High
Dorsal horn 72 100.00 Very High Very High Very High
Morphine 39 100.00 Very High Very High Very High
nociceptor 4 100.00 Very High Very High Very High
Rostral ventromedial medulla 6 99.98 Very High Very High Very High
antagonist 81 99.86 Very High Very High Very High
opioid receptor 121 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 126 99.84 Very High Very High Very High
Nociception 179 99.60 Very High Very High Very High
Neuropathic Pain 199 99.44 Very High Very High Very High
Neuritis 4 99.42 Very High Very High Very High
Pain 180 99.28 Very High Very High Very High
Hyperalgesia 75 98.80 Very High Very High Very High
Pulmonary Hypertension 150 98.66 Very High Very High Very High
Diabetes Mellitus 289 98.64 Very High Very High Very High
Anxiety Disorder 241 98.12 Very High Very High Very High
Frailty 5 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal administration of PD98059, a specific inhibitor of ERK phosphorylation, reduced the frequency and amplitude of bladder contractions in SCI animals but not in spinal intact ones.
Negative_regulation (inhibitor) of Phosphorylation (phosphorylation) of ERK in spinal associated with frailty and intrathecal
1) Confidence 0.59 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.89 Pain Relevance 0.47
Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats.
Negative_regulation (Inhibition) of Phosphorylation (phosphorylation) of ERK associated with nociception and nociceptor
2) Confidence 0.58 Published 2005 Journal Pain Section Title Doc Link 15979799 Disease Relevance 0.61 Pain Relevance 0.43
Intrathecal administration of PD 98059, an inhibitor of ERK phosphorylation, reduced nociceptive behaviour induced by the ankle bend test in monoarthritic rats.
Negative_regulation (inhibitor) of Phosphorylation (phosphorylation) of ERK in ankle associated with nociception and intrathecal
3) Confidence 0.58 Published 2005 Journal Pain Section Abstract Doc Link 15979799 Disease Relevance 0.67 Pain Relevance 0.39
Finally, we used a specific inhibitor of ERK phosphorylation to study the influence of these kinases on the bladder reflex activity of normal and inflamed bladders.
Negative_regulation (inhibitor) of Phosphorylation (phosphorylation) of ERK in bladders
4) Confidence 0.57 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733095 Disease Relevance 0.23 Pain Relevance 0.25
By preventing ERK phosphorylation, the levels of allodynia and hyperalgesia are reduced.
Negative_regulation (preventing) of Phosphorylation (phosphorylation) of ERK associated with hyperalgesia and allodynia
5) Confidence 0.57 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.56 Pain Relevance 0.55
On this ground, inhibitors of ERK phosphorylation have been used in order to reverse those altered pain states.
Negative_regulation (inhibitors) of Phosphorylation (phosphorylation) of ERK associated with pain
6) Confidence 0.57 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.86 Pain Relevance 0.87
On the other hand, supraspinal input may also inhibit spinal ERK phosphorylation.
Spec (may) Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of ERK in spinal
7) Confidence 0.57 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.24 Pain Relevance 0.53
In all cases, blockade of ERK phosphorylation lead to downregulation of the contents of BDNF and NPY, correlating with improvement in pain hypersensitivity.
Negative_regulation (blockade) of Phosphorylation (phosphorylation) of ERK associated with hypersensitivity and stimulus evoked pain
8) Confidence 0.57 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.72 Pain Relevance 0.67
Furthermore, attenuation of the spinal ERK phosphorylation by intrathecal a MAPK kinase (MEK) inhibitor U0126 or knockdown of the spinal ERK by antisense oligonucleotides not only decreased the scores of morphine withdrawal, but also attenuated withdrawal-induced allodynia, which were accompanied by decreased ERK phosphorylation in the spinal cord.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of ERK in spinal associated with allodynia, withdrawal, spinal cord, morphine and intrathecal
9) Confidence 0.57 Published 2005 Journal Pain Section Abstract Doc Link 16289800 Disease Relevance 0.31 Pain Relevance 1.34
The intrathecal injection of a MEK inhibitor, U0126, reduced the phosphorylation of ERK in DRG neurons and alleviated the struggle behavior elicited by the passive movement of the joint.
Negative_regulation (educed ) of Phosphorylation (hosphorylation ) of ERK in joint associated with dorsal root ganglion and intrathecal
10) Confidence 0.56 Published 2006 Journal Pain Section Abstract Doc Link 16616417 Disease Relevance 1.20 Pain Relevance 0.66
Conversely, imipramine did not reduce the hippocampal phosphorylation of both ERK subtypes whereas it selectively increased ERK 1 phosphorylation in the cytosolic compartment of frontal cortex suggesting a drug-specific effect on this intracellular target.
Neg (not) Negative_regulation (reduce) of Phosphorylation (phosphorylation) of ERK in frontal cortex associated with urological neuroanatomy
11) Confidence 0.54 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935071 Disease Relevance 0.28 Pain Relevance 0.61
Microinjection of U0126, a mitogen-activated protein kinase kinase inhibitor, into the RVM decreased phosphorylated ERK at 7 h after complete Freund's adjuvant (CFA) injection into the hindpaw.
Negative_regulation (decreased) of Phosphorylation (phosphorylated) of ERK in RVM associated with rostral ventromedial medulla
12) Confidence 0.48 Published 2008 Journal Brain Res. Section Abstract Doc Link 18037394 Disease Relevance 0.52 Pain Relevance 0.74
The MEK1/2 inhibitor PD98059 was used as the inhibitor for ERK phosphorylation.
Negative_regulation (inhibitor) of Phosphorylation (phosphorylation) of ERK
13) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2661045 Disease Relevance 0 Pain Relevance 0.14
It is well documented that the i.t. administration of the MEK inhibitor PD98059 causes a significant reduction of ERK phosphorylation in Vc neurons as well as spinal DH neurons [47].
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of ERK in neurons associated with spinal dorsal horn
14) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2661045 Disease Relevance 0.53 Pain Relevance 0.85
RESULTS: Procaine (10(-4) to 10(-3) M) inhibited carbachol-induced tyrosine phosphorylation and ERK activation in a concentration-dependent manner.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of ERK
15) Confidence 0.43 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Although tetracaine, lidocaine, and bupivacaine similarly suppressed carbachol-induced tyrosine phosphorylation and ERK activation, neither tetrodotoxin, veratridine, nor ouabain affected the carbachol-induced ERKs activation.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of ERK
16) Confidence 0.43 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
In fact, experiments using specific inhibitors of ERK phosphorylation have proved that ERK directly contributes to allodynia and hyperalgesia caused by spinal cord injury or chronic pain.
Negative_regulation (inhibitors) of Phosphorylation (phosphorylation) of ERK in spinal cord associated with hyperalgesia, allodynia, lasting pain and spinal cord
17) Confidence 0.42 Published 2007 Journal Current Neuropharmacology Section Abstract Doc Link PMC2644492 Disease Relevance 0.99 Pain Relevance 0.72
ERK phosphorylation in response to acute noxious stimulation has also been described in these cells.
Negative_regulation (described) of Phosphorylation (phosphorylation) of ERK
18) Confidence 0.41 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.36 Pain Relevance 0.34
Furthermore, attenuation of the spinal ERK phosphorylation by intrathecal a MAPK kinase (MEK) inhibitor U0126 or knockdown of the spinal ERK by antisense oligonucleotides not only decreased the scores of morphine withdrawal, but also attenuated withdrawal-induced allodynia, which were accompanied by decreased ERK phosphorylation in the spinal cord.
Negative_regulation (attenuation) of Phosphorylation (phosphorylation) of ERK in spinal associated with allodynia, withdrawal, spinal cord, morphine and intrathecal
19) Confidence 0.41 Published 2005 Journal Pain Section Abstract Doc Link 16289800 Disease Relevance 0.27 Pain Relevance 1.02
The result of Western blotting showed that the phosphorylation level of ERK 1/2 in the spinal cord was increased at one hour; then 12 and 24 h after LPS injection the level decreased, while the total ERK 1/2 level seemed unchanged.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of ERK in spinal cord associated with spinal cord
20) Confidence 0.41 Published 2008 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 18311521 Disease Relevance 0.16 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox