INT84495

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 5
Speculated 8
Reported most in Abstract
Documents 85
Total Number 92
Disease Relevance 46.12
Pain Relevance 54.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 24
spinal 15
dorsal horn 8
paw 8
RVM 6
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 498 100.00 Very High Very High Very High
allodynia 272 100.00 Very High Very High Very High
Anterior cingulate cortex 262 100.00 Very High Very High Very High
amygdala 248 100.00 Very High Very High Very High
Lasting pain 204 100.00 Very High Very High Very High
Dorsal horn 184 100.00 Very High Very High Very High
Central nervous system 104 100.00 Very High Very High Very High
spinal dorsal horn 54 100.00 Very High Very High Very High
Morphine 36 100.00 Very High Very High Very High
Locus ceruleus 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 833 100.00 Very High Very High Very High
Neuropathic Pain 657 100.00 Very High Very High Very High
Nervous System Injury 393 100.00 Very High Very High Very High
Injury 284 100.00 Very High Very High Very High
Stress 240 100.00 Very High Very High Very High
Apoptosis 83 100.00 Very High Very High Very High
INFLAMMATION 456 99.98 Very High Very High Very High
Spinal Injuries 24 99.98 Very High Very High Very High
Gliosis 12 99.98 Very High Very High Very High
Ganglion Cysts 40 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it was demonstrated that ERK activation is upregulated in the spinal cord of rats with chronic bladder inflammation and contributes to bladder overactivity.
Positive_regulation (upregulated) of Positive_regulation (activation) of ERK in bladder associated with inflammation and spinal cord
1) Confidence 0.70 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.78 Pain Relevance 0.48
Although tetracaine, lidocaine, and bupivacaine similarly suppressed carbachol-induced tyrosine phosphorylation and ERK activation, neither tetrodotoxin, veratridine, nor ouabain affected the carbachol-induced ERKs activation.
Positive_regulation (induced) of Positive_regulation (activation) of ERK
2) Confidence 0.69 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
In fact, while some studies demonstrated that SP induces spinal ERK activation [54, 108], other have provided opposing data [61].
Positive_regulation (induces) of Positive_regulation (activation) of ERK in spinal associated with substance p
3) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.13 Pain Relevance 0.57
In what concerns spinal ERK phosphorylation after visceral inflammation, the scarce studies available show that noxious stimulation of the chronic inflamed colon and bladder induces prolonged and intense ERK activation in the lumbosacral spinal cord [24, 36] where most of the primary afferents innervating these organs terminate.
Positive_regulation (induces) of Positive_regulation (activation) of ERK in colon associated with inflammation and spinal cord
4) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.66 Pain Relevance 0.52
The involvement of the spinal ERK in morphine withdrawal was supported by our finding that intrathecal N-methyl-D-aspartate receptor antagonist MK-801 or protein kinase C inhibitor chelerythrine chloride suppressed withdrawal-induced ERK activation in the spinal cord and attenuated morphine withdrawal symptoms.
Positive_regulation (induced) of Positive_regulation (activation) of ERK in spinal cord associated with antagonist, nmda receptor, withdrawal, spinal cord, kinase c inhibitor, intrathecal and morphine
5) Confidence 0.68 Published 2005 Journal Pain Section Abstract Doc Link 16289800 Disease Relevance 0.29 Pain Relevance 1.54
There was a further increase in ERK activation after naloxone-precipitated withdrawal.
Positive_regulation (increase) of Positive_regulation (activation) of ERK associated with narcan and withdrawal
6) Confidence 0.68 Published 2005 Journal Pain Section Abstract Doc Link 16289800 Disease Relevance 0.26 Pain Relevance 0.85
To our surprise, there was significantly enhanced activation of Erk in the ACC neurons after brushing the amputated hindpaw.
Positive_regulation (enhanced) of Positive_regulation (activation) of Erk in ACC neurons associated with anterior cingulate cortex
7) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.86 Pain Relevance 0.86
In supraspinal structures, it has been reported that activation of Erk in the amygdala is induced by peripheral injury [6], and the increased Erk activity in this region is acquired for behavioral sensitization to mechanical stimulation after injury [7].
Positive_regulation (induced) of Positive_regulation (activation) of Erk in amygdala associated with injury and amygdala
8) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.95 Pain Relevance 0.88
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
Positive_regulation (induced) of Positive_regulation (activation) of ERK in dorsal horn associated with c fibre, kinase c, qutenza, central sensitization and dorsal horn neuron
9) Confidence 0.61 Published 2004 Journal J. Neurosci. Section Title Doc Link 15385614 Disease Relevance 0 Pain Relevance 0.95
These findings suggest that activation of ERK in the LC is induced by acute noxious stimulation, such as formalin injection, but not by CFA-induced chronic inflammation.
Neg (not) Positive_regulation (induced) of Positive_regulation (activation) of ERK associated with inflammation and locus ceruleus
10) Confidence 0.60 Published 2009 Journal Brain Res. Section Abstract Doc Link 19368817 Disease Relevance 0.24 Pain Relevance 0.60
Conversely, the rapid activation of the 44-kDa isoform of ERK after 5 min of reperfusion in the cytosolic fraction was significantly increased in IPC- and opioid-treated hearts versus control, and this increase was abolished by pretreatment with PD 098059.
Positive_regulation (increased) of Positive_regulation (activation) of ERK in hearts associated with opioid
11) Confidence 0.60 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11160653 Disease Relevance 0.14 Pain Relevance 0.51
Additionally, myocardial ischemia/reperfusion induces the activation of extracellular signal-regulated kinase (ERK).
Positive_regulation (induces) of Positive_regulation (activation) of ERK associated with coronary artery disease and ischemia
12) Confidence 0.60 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11160653 Disease Relevance 0.10 Pain Relevance 0.29
Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury.
Positive_regulation (induced) of Positive_regulation (activation) of ERK in spinal associated with nervous system injury, qutenza, spinal dorsal horn and peripheral nerve injury
13) Confidence 0.59 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 15009135 Disease Relevance 0.58 Pain Relevance 0.40
Enhancement of ERK activation induced by 3 mA stimulation was also observed.
Positive_regulation (Enhancement) of Positive_regulation (activation) of ERK
14) Confidence 0.59 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15009135 Disease Relevance 0.70 Pain Relevance 0.46
Inflammation induced the activation of ERK in the RVM, with a peak at 7 h after the injection of CFA into the hindpaw and a duration of 24 h.
Positive_regulation (induced) of Positive_regulation (activation) of ERK in RVM associated with inflammation and rostral ventromedial medulla
15) Confidence 0.52 Published 2005 Journal Brain Res. Section Abstract Doc Link 16288729 Disease Relevance 0.47 Pain Relevance 0.61
Overall, our results demonstrate increased activation of the ERK pathway in the spinal cord from SCI rats, restricted to spinal segments that receive sensory input arising from the bladder.
Positive_regulation (increased) of Positive_regulation (activation) of ERK in bladder associated with frailty and spinal cord
16) Confidence 0.50 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.85 Pain Relevance 0.44
The inhibition of carbachol-induced ERK activation by procaine was not modified by a phosphatase inhibitor, calyculin A.
Positive_regulation (carbachol-induced) of Positive_regulation (activation) of ERK
17) Confidence 0.50 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Then, in the presence of local anesthetic, the carbachol-induced tyrosine phosphorylation and ERK activation were evaluated.
Positive_regulation (carbachol-induced) of Positive_regulation (activation) of ERK
18) Confidence 0.50 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Taken together, the excitation of CCD neurons might be attributed to the CCD-induced activation of ERK, which suppressed the A-type fast inactivating potassium conductance in CCD neurons.
Spec (might) Positive_regulation (attributed) of Positive_regulation (activation) of ERK in neurons
19) Confidence 0.49 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17490811 Disease Relevance 0.43 Pain Relevance 0.25
Our findings suggest that cortical activation of Erk may contribute to both induction and expression of chronic pain.



Positive_regulation (induction) of Positive_regulation (activation) of Erk associated with lasting pain
20) Confidence 0.49 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2503974 Disease Relevance 1.00 Pain Relevance 0.89

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