INT84496

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 4
Speculated 9
Reported most in Body
Documents 18
Total Number 27
Disease Relevance 10.16
Pain Relevance 13.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
brain 4
lamina 4
medulla 3
caudate putamen 3
amygdala 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 84 100.00 Very High Very High Very High
Morphine 55 100.00 Very High Very High Very High
withdrawal 37 99.98 Very High Very High Very High
addiction 5 99.98 Very High Very High Very High
Sciatica 2 99.92 Very High Very High Very High
Rostral ventromedial medulla 247 99.84 Very High Very High Very High
Opioid 25 99.78 Very High Very High Very High
Nucleus accumbens 8 99.68 Very High Very High Very High
Neuronal excitability 4 99.68 Very High Very High Very High
Kinase C 7 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 167 100.00 Very High Very High Very High
Stress 38 100.00 Very High Very High Very High
Opiate Addiction 5 99.98 Very High Very High Very High
Injury 80 99.62 Very High Very High Very High
INFLAMMATION 71 99.48 Very High Very High Very High
Neuropathic Pain 78 99.20 Very High Very High Very High
Hyperplasia 5 99.04 Very High Very High Very High
Hypoxia 103 98.76 Very High Very High Very High
Pain 173 98.72 Very High Very High Very High
Nociception 72 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both ERKs were also activated by 4beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C, and fluoroaluminate (AlF4-), respectively, but procaine did not affect ERK activation induced by these two substances.
Neg (not) Regulation (affect) of Positive_regulation (activation) of ERK
1) Confidence 0.61 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
The role of ERK activation in the neuronal excitability in the chronically compressed dorsal root ganglia.
Regulation (role) of Positive_regulation (activation) of ERK in neuronal associated with neuronal excitability and sciatica
2) Confidence 0.44 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17490811 Disease Relevance 0.42 Pain Relevance 0.46
In both cases, several changes occur in the nervous system, which depend on the activation of the ERK pathway at the different neuronal levels, including dorsal root ganglia (DRG), spinal cord and supraspinal centres.
Regulation (depend) of Positive_regulation (activation) of ERK in dorsal root ganglia associated with spinal cord
3) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.61 Pain Relevance 0.65
Although tetracaine, lidocaine, and bupivacaine similarly suppressed carbachol-induced tyrosine phosphorylation and ERK activation, neither tetrodotoxin, veratridine, nor ouabain affected the carbachol-induced ERKs activation.
Neg (neither) Regulation (affected) of Positive_regulation (carbachol-induced) of ERK
4) Confidence 0.44 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
The present study examined the regulation of ERK and Akt activation in the nucleus accumbens and caudate putamen following acute and chronic morphine administration in the rat.
Spec (examined) Regulation (regulation) of Spec (examined) Positive_regulation (activation) of ERK in caudate putamen associated with nucleus accumbens and morphine
5) Confidence 0.43 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.53
We investigated the role of lamina I projection neurones in the increase in mechanical sensitivity seen in SNI rats and the associated activation of ERK in the RVM.
Spec (investigated) Regulation (role) of Positive_regulation (activation) of ERK in lamina associated with nervous system injury and rostral ventromedial medulla
6) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.01 Pain Relevance 0.36
A variety of neuromodulator/neurotransmitter receptors, including metabotropic glutamate receptors that are important for pain-related plasticity in the amygdala [12,16], have been shown to couple to ERK activation via PKA and PKC [61].
Regulation (couple) of Positive_regulation (activation) of ERK in amygdala associated with pain, neurotransmitter, glutamate receptor and amygdala
7) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.28 Pain Relevance 0.85
Furthermore, as the mitogen-activated protein kinase kinase 1 (MAPKK1) was increased significantly in the stages of establishment and reinstatement, we confirmed the change of activated extracellular signal-regulated kinase (ERK) by Western blotting in VTA tissue and cultured cell.
Regulation (change) of Positive_regulation (activated) of ERK associated with ventral tegmentum
8) Confidence 0.33 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20091775 Disease Relevance 0.13 Pain Relevance 1.24
In this study we investigated the role of the activation of the extracellular signal-regulated kinases 1 and 2 (ERK) in chronic inflammatory articular nociception.
Spec (investigated) Regulation (role) of Spec (investigated) Positive_regulation (activation) of ERK in articular associated with nociception and inflammation
9) Confidence 0.27 Published 2005 Journal Pain Section Abstract Doc Link 15979799 Disease Relevance 0.40 Pain Relevance 0.19
Opioid addiction modulates the extracellular signal-regulated kinase (ERK) leading to synaptic plasticity in the brain.
Regulation (modulates) of Positive_regulation (leading) of ERK in brain associated with addiction and opioid
10) Confidence 0.26 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16678156 Disease Relevance 0.25 Pain Relevance 0.81
We thus examined the involvement of the NMDA receptor on frequency-dependent ERK activation in laminae I-II.
Spec (examined) Regulation (involvement) of Spec (examined) Positive_regulation (activation) of ERK associated with nmda receptor
11) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.32
Hence, the objective of this work was to investigate the time-dependent changes in the activation of ERK in crushed sciatic nerve with correlation to the cell types.


Spec (investigate) Regulation (changes) of Positive_regulation (activation) of ERK in sciatic nerve associated with sciatic nerve
12) Confidence 0.25 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.42 Pain Relevance 0.36
In conclusion, alagebrium inhibits neointimal hyperplasia after carotid balloon injury because it blocks intracellular ROS synthesis and ERK activation, resulting in inhibition of RASMCs proliferation.
Regulation (intracellular) of Positive_regulation (activation) of ERK associated with injury and hyperplasia
13) Confidence 0.25 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.69 Pain Relevance 0
We have therefore investigated the influence of lamina I/III projection neurones on ERK activation in the RVM in both neuropathic and inflammatory pain models.
Spec (investigated) Regulation (influence) of Positive_regulation (activation) of ERK in lamina associated with ipn, neuropathic pain and rostral ventromedial medulla
14) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.34 Pain Relevance 1.49
Subsequent experiments tested the effect of these drug treatments on the activation of the ERK/MAPK signaling pathway in various brain regions following extinction training.
Regulation (effect) of Positive_regulation (activation) of ERK in brain
15) Confidence 0.24 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Abstract Doc Link PMC2927240 Disease Relevance 0.38 Pain Relevance 0.56
The effects of acute and chronic restraint stress on activation of ERK in the rostral ventromedial medulla and locus coeruleus.
Regulation (effects) of Positive_regulation (activation) of ERK in medulla associated with stress, locus ceruleus and rostral ventromedial medulla
16) Confidence 0.23 Published 2004 Journal Pain Section Title Doc Link 15561392 Disease Relevance 0.65 Pain Relevance 0.80
Morphine withdrawal modulates gene expression in the NTS through various second-messenger signal transduction systems including activation of extracellular signal-regulated kinases 1/2 (ERK(1/2)) and protein kinase C (PKC).
Regulation (modulates) of Positive_regulation (activation) of ERK associated with kinase c, withdrawal and morphine
17) Confidence 0.22 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.17 Pain Relevance 0.69
The role of pERK activation in RVM at 3 days post SNI is not clear.
Regulation (role) of Positive_regulation (activation) of pERK associated with nervous system injury and rostral ventromedial medulla
18) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.67 Pain Relevance 1.19
The present study examined the regulation of ERK and Akt activation in the nucleus accumbens and caudate putamen following acute and chronic morphine administration in the rat.
Spec (examined) Regulation (regulation) of in nucleus accumbens Spec (examined) Positive_regulation (activation) of ERK in caudate putamen associated with nucleus accumbens and morphine
19) Confidence 0.14 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.53
Previous studies have suggested that CNS events leading to central sensitization during peripheral inflammation, hippocampal regulation due to stress, or long-term potentiation associated with spatial learning and memory may be dependent on similar intracellular transduction mechanisms, primarily the activation of cytosolic ERK and subsequent phosphorylation of nuclear CREB [29,45-50].
Spec (may) Regulation (dependent) of Positive_regulation (activation) of cytosolic ERK associated with stress, inflammation, central sensitization, long-term potentiation and central nervous system
20) Confidence 0.12 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.79 Pain Relevance 0.61

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