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Context Info
Confidence 0.40
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrm3, Ephb1) endosome (Ephb1) signal transduction (Ephb1)
cytoplasm (Ephb1) signal transducer activity (Chrm3)
Chrm3 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
local anesthetic 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pheochromocytoma 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The current results indicate that local anesthetics inhibit the activity of the signal-transducing molecule(s) leading to M3 muscarinic acetylcholine receptor-mediated ERK activation in PC12 cells.
M3 muscarinic acetylcholine receptor Positive_regulation (activation) of ERK
1) Confidence 0.40 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0

General Comments

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