INT84510

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 9.52
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Nf1) signal transduction (Nf1) nucleus (Nf1)
intracellular (Nf1) extracellular matrix organization (Nf1) protein complex (Nf1)
Anatomy Link Frequency
sensory neurons 2
brains 1
limbs 1
Nf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 6 100.00 Very High Very High Very High
qutenza 6 98.02 Very High Very High Very High
dopamine receptor 24 96.08 Very High Very High Very High
Pain 9 93.24 High High
gABA 21 91.96 High High
Enkephalin 4 86.68 High High
Action potential 6 86.56 High High
alcohol 1 81.40 Quite High
addiction 3 80.92 Quite High
long-term potentiation 15 78.48 Quite High
Disease Link Frequency Relevance Heat
Watson Syndrome 179 100.00 Very High Very High Very High
Cancer 149 99.98 Very High Very High Very High
Shock 6 99.98 Very High Very High Very High
Alzheimer's Dementia 9 99.64 Very High Very High Very High
Injury 6 98.76 Very High Very High Very High
Cleidocranial Dysplasia 30 98.48 Very High Very High Very High
Targeted Disruption 29 98.36 Very High Very High Very High
Cognitive Disorder 60 97.04 Very High Very High Very High
Congenital Anomalies 6 95.76 Very High Very High Very High
Pain 3 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heat-shock induced neurofibromin was expressed in adult NF1-/- fruit flies, rescuing the learning deficits, indicating that developmental factors are not causing the cognitive deficits [10].
Positive_regulation (induced) of neurofibromin associated with cognitive disorder, shock and watson syndrome
1) Confidence 0.69 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.80 Pain Relevance 0
Haploinsufficiency of NF1 may also play a pathogenetic role for some features.
Positive_regulation (Haploinsufficiency) of NF1 associated with watson syndrome
2) Confidence 0.50 Published 2008 Journal BMC Med Section Body Doc Link PMC2531128 Disease Relevance 1.68 Pain Relevance 0.06
The Nf1 heterozygous mice do not develop tibial dysplasia, but Kolanczyk et al [16] did obtain mice with tibial bowing by homozygous inactivation of Nf1 in developing limbs using a conditional knock-out system.
Positive_regulation (inactivation) of Nf1 in limbs associated with targeted disruption and cleidocranial dysplasia
3) Confidence 0.50 Published 2008 Journal BMC Med Section Body Doc Link PMC2531128 Disease Relevance 0.79 Pain Relevance 0
Using patch-clamp electrophysiological techniques, we examined the excitability of capsaicin-sensitive sensory neurons isolated from the dorsal root ganglia of adult mice with a heterozygous mutation of the Nf1 gene (Nf1+/-), analogous to the human mutation, in comparison to wildtype sensory neurons.
Positive_regulation (mutation) of Nf1 in sensory neurons associated with qutenza
4) Confidence 0.50 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16093333 Disease Relevance 0.68 Pain Relevance 0.28
Using patch-clamp electrophysiological techniques, we examined the excitability of capsaicin-sensitive sensory neurons isolated from the dorsal root ganglia of adult mice with a heterozygous mutation of the Nf1 gene (Nf1+/-), analogous to the human mutation, in comparison to wildtype sensory neurons.
Positive_regulation (mutation) of Nf1 in sensory neurons associated with qutenza
5) Confidence 0.50 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16093333 Disease Relevance 0.68 Pain Relevance 0.29
Neurofibromin is a guanosine triphosphatase activating protein (GAP) for Ras and accelerates the conversion of active Ras-GTP to inactive Ras-GDP; therefore mutation of the NF1 gene frequently results in an increase in activity of the Ras transduction cascade.
Positive_regulation (mutation) of NF1 associated with watson syndrome
6) Confidence 0.50 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16093333 Disease Relevance 0.79 Pain Relevance 0.23
Gene expression analysis shows a 2.7 fold increase in the expression of dopamine 3 receptor in Nf1+/- brains at post natal day 15.
Positive_regulation (increase) of Nf1 in brains associated with dopamine
7) Confidence 0.50 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.09 Pain Relevance 0.23
The results of our network analysis are shown in Figure 2, implying a functional connection between neurofibromin and the amyloid beta precursor protein/integrin/filamin complex, which is in turn related to the dopamine receptors (Drd3).
Positive_regulation (connection) of neurofibromin associated with dopamine receptor and alzheimer's dementia
8) Confidence 0.50 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.44 Pain Relevance 0.31
Tumors occur in NF1 patients by a classic two-hit model, indicating that the NF1 gene is a tumor suppressor [7,8].
Positive_regulation (occur) of NF1 associated with cancer and watson syndrome
9) Confidence 0.44 Published 2008 Journal BMC Med Section Body Doc Link PMC2531128 Disease Relevance 2.51 Pain Relevance 0.09
These results suggest that MMR deficiency can accelerate myeloid leukemogenesis in Nf1+/?
Positive_regulation (accelerate) of Nf1
10) Confidence 0.33 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.82 Pain Relevance 0.03
This region contains all the inducible regulatory elements (enkCRE1, NF1, AP-2, NFkappaB, etc.) and also an octamer-like element at -543 bp.
Spec (like) Positive_regulation (inducible) of NF1
11) Confidence 0.29 Published 1998 Journal DNA Seq. Section Abstract Doc Link 10520752 Disease Relevance 0.23 Pain Relevance 0.39

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