INT84511

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.72
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tfap2a) Golgi apparatus (Tfap2a) nucleus (Tfap2a)
DNA binding (Tfap2a) transcription factor binding (Tfap2a) cytoplasm (Tfap2a)
Anatomy Link Frequency
adipocyte 1
Tfap2a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 7 99.10 Very High Very High Very High
Enkephalin 4 86.68 High High
alcohol 1 81.40 Quite High
addiction 1 80.92 Quite High
Endogenous opioid 1 75.64 Quite High
agonist 39 68.08 Quite High
Inflammation 30 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 10 95.96 Very High Very High Very High
Obesity 24 87.80 High High
Alcohol Addiction 1 81.64 Quite High
Drug Dependence 1 80.92 Quite High
Sprains And Strains 1 68.00 Quite High
Hematological Disease 6 52.44 Quite High
Fibrodysplasia Ossificans Progressiva 19 50.00 Quite Low
Hepatocellular Cancer 2 8.04 Low Low
INFLAMMATION 35 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine treatment was also found to lead to a local increase in two other components of the endocytic machinery, dynamin and AP-2, suggesting a critical involvement of the endocytic machinery in the modulatory effects of morphine.
Positive_regulation (increase) of AP-2 associated with morphine
1) Confidence 0.27 Published 2007 Journal Mol. Cell Proteomics Section Abstract Doc Link 17028301 Disease Relevance 0 Pain Relevance 0.58
In contrast the mRNA for the adipocyte-specific fatty acids binding protein aP2 was increased.
Positive_regulation (increased) of aP2 in adipocyte
2) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.49 Pain Relevance 0
This region contains all the inducible regulatory elements (enkCRE1, NF1, AP-2, NFkappaB, etc.) and also an octamer-like element at -543 bp.
Spec (like) Positive_regulation (inducible) of AP-2
3) Confidence 0.10 Published 1998 Journal DNA Seq. Section Abstract Doc Link 10520752 Disease Relevance 0.23 Pain Relevance 0.39
Induction of Fabp4 (A-FABP, aP2) upon PPAR?
Positive_regulation (Induction) of aP2
4) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.07

General Comments

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