INT84512

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.48
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Myoz1)
Anatomy Link Frequency
heart 1
stem 1
Myoz1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 10 100.00 Very High Very High Very High
qutenza 4 99.80 Very High Very High Very High
depression 1 98.52 Very High Very High Very High
Central nervous system 1 95.12 Very High Very High Very High
Neuropathic pain 2 92.64 High High
pruritus 42 86.16 High High
dysesthesia 1 84.56 Quite High
Cannabinoid receptor 1 82.60 Quite High
Opioid 1 81.52 Quite High
Analgesic 1 78.00 Quite High
Disease Link Frequency Relevance Heat
Disease 9 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 1 100.00 Very High Very High Very High
Anxiety Disorder 1 99.04 Very High Very High Very High
Drug Induced Neurotoxicity 1 98.68 Very High Very High Very High
Depression 1 98.52 Very High Very High Very High
Confusion 1 98.04 Very High Very High Very High
Hyperlipidemia 4 97.80 Very High Very High Very High
Brain Injury 5 97.76 Very High Very High Very High
Necrosis 3 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since CsA also has known interactions with calcineurin and may be providing neuroprotection through that mechanism, additional animals were treated with the immunosuppressant FK 506.
calcineurin Binding (interactions) of
1) Confidence 0.30 Published 1999 Journal J. Neurotrauma Section Abstract Doc Link 10521138 Disease Relevance 0.82 Pain Relevance 0.07
The calcineurin inhibitors (CNIs) ciclosporin (CsA) and tacrolimus are currently an important part of immunosuppressive regimens, but are associated with increased cardiovascular risk factors, including hyperlipidaemia, hypertension and diabetes mellitus.
calcineurin Binding (associated) of associated with diabetes mellitus, hypertension and hyperlipidemia
2) Confidence 0.26 Published 2006 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 16815856 Disease Relevance 0.67 Pain Relevance 0.13
In current studies there is indirect evidence that next to capsaicin also the calcineurin inhibitors may bind to the TRPV1 (Ständer, Steinhoff, Ständer, et al 2003; Senba et al 2004).
calcineurin Binding (bind) of associated with qutenza
3) Confidence 0.14 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661653 Disease Relevance 1.03 Pain Relevance 0.61
Recently, calcineurin-inhibitor-induced pain syndrome, characterized by severe pain in the lower limbs, has also been recognized in both organ and stem-cell transplantations.
calcineurin Binding (recognized) of in stem associated with pain
4) Confidence 0.13 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17959987 Disease Relevance 0.66 Pain Relevance 0.32
The calcineurin inhibitors (CIs) cyclosporine A and tacrolimus are essential for graft-versus-host disease prophylaxis but are associated with adverse effects, including neurotoxicity.
calcineurin Binding (associated) of associated with drug induced neurotoxicity and disease
5) Confidence 0.12 Published 2006 Journal Int. J. Hematol. Section Abstract Doc Link 16787880 Disease Relevance 0.77 Pain Relevance 0.57
Thus, loss of calcineurin-NFAT signaling is required for the proper differentiation of most tissues analyzed with the CnB1-loxP allele.
calcineurin Binding (loss) of
6) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.28 Pain Relevance 0
In the heart, calcineurin was necessary for proper development and homeostasis in adulthood, most likely associated with alterations in differentiated gene expression.


calcineurin Binding (associated) of in heart
7) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.26 Pain Relevance 0
Also in adults basiliximab may provoke drug interactions with calcineurin inhibitors.
calcineurin Binding (interactions) of
8) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721359 Disease Relevance 0 Pain Relevance 0

General Comments

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