INT84527

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 15.83
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) extracellular region (F3)
plasma membrane (F3) cytoplasm (F3)
Anatomy Link Frequency
leukocytes 6
chest 6
platelet 6
macrophages 4
blood 2
F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 136 99.98 Very High Very High Very High
Inflammation 279 99.78 Very High Very High Very High
Angina 54 96.12 Very High Very High Very High
Inflammatory response 29 95.96 Very High Very High Very High
Inflammatory stimuli 3 92.52 High High
Potency 1 88.32 High High
chemokine 10 84.60 Quite High
corticosteroid 39 84.48 Quite High
aspirin 20 83.60 Quite High
imagery 2 79.60 Quite High
Disease Link Frequency Relevance Heat
Adhesions 55 100.00 Very High Very High Very High
Thrombocytopenia 12 100.00 Very High Very High Very High
Thrombosis 85 99.92 Very High Very High Very High
Coagulation Disorder 27 99.80 Very High Very High Very High
INFLAMMATION 332 99.78 Very High Very High Very High
Cancer 355 99.52 Very High Very High Very High
Pathologic Neovascularization 1 99.36 Very High Very High Very High
Acute Coronary Syndrome 98 99.24 Very High Very High Very High
Sepsis 5 99.24 Very High Very High Very High
Hypoxia 5 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Spec (partial) Positive_regulation (activated) of Spec (partial) Gene_expression (time) of thromboplastin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.56 Pain Relevance 0.07
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Spec (partial) Positive_regulation (elevated) of Spec (partial) Gene_expression (time) of thromboplastin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.57 Pain Relevance 0.07
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Positive_regulation (as) of Spec (partial) Gene_expression (time) of thromboplastin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
3) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.57 Pain Relevance 0.08
Hence, this study investigates whether histamine induces tissue factor (TF) expression in vascular cells.
Spec (whether) Positive_regulation (induces) of Gene_expression (expression) of tissue factor
4) Confidence 0.38 Published 2005 Journal Circulation Section Abstract Doc Link 16009787 Disease Relevance 0.45 Pain Relevance 0.09
During Gram-negative septic shock, lipopolysaccharide (LPS, endotoxin) induces tissue factor (TF) expression.
Positive_regulation (induces) of Gene_expression (expression) of tissue factor associated with sepsis
5) Confidence 0.32 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.10 Pain Relevance 0.21
Under sterile and endotoxin-free conditions, the process does not activate tissue factor expression by monocytes.
Neg (not) Positive_regulation (activate) of Gene_expression (expression) of tissue factor in monocytes
6) Confidence 0.31 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0.05
Histamine induces tissue factor expression: implications for acute coronary syndromes.
Positive_regulation (induces) of Gene_expression (expression) of tissue factor associated with acute coronary syndrome
7) Confidence 0.25 Published 2005 Journal Circulation Section Title Doc Link 16009787 Disease Relevance 0.48 Pain Relevance 0.10
Her alanine aminotransferase (ALT) was mildly elevated at 53 U/L (reference range <45 U/L) but other liver function tests, international normalized ration (INR) and activated partial thromboplastin time (APTT), electrolytes, urea, creatinine, amylase, lipase, full blood count, erythrocyte sedimentation rate (ESR), and C-reactive protein, were all within the normal ranges.
Spec (partial) Positive_regulation (activated) of Spec (partial) Gene_expression (time) of thromboplastin in blood
8) Confidence 0.21 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2997096 Disease Relevance 0.86 Pain Relevance 0.18
Furthermore, the production of tissue factor or inhibition of tissue-factor-pathway-inhibitor (TFPI) activates the extrinsic coagulation pathway [2,14], while the simultaneous decreased production of prostacyclin induces vasoconstriction and platelet aggregation.
Positive_regulation (activates) of Gene_expression (production) of tissue factor in platelet associated with increased venous pressure under development
9) Confidence 0.12 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987921 Disease Relevance 0.75 Pain Relevance 0
This increased lipid accumulation was accompanied by enhanced expression of tissue factor and plasminogen activator inhibitor-1, as well as enhanced thrombin formation, transforming macrophages into a prothrombotic phenotype.
Positive_regulation (enhanced) of Gene_expression (expression) of tissue factor in macrophages
10) Confidence 0.11 Published 2005 Journal Circulation Section Body Doc Link 16186421 Disease Relevance 0 Pain Relevance 0
Endothelial cells incubated with sickle mononuclear leukocytes were more activated than those incubated with normal mononuclear leukocytes, as judged by the increased endothelial expression of adhesion molecules and tissue factor and the adhesion of polymorphonuclear leukocytes (PMNL).
Positive_regulation (increased) of Gene_expression (expression) of tissue factor in leukocytes associated with adhesions
11) Confidence 0.09 Published 2000 Journal Blood Section Abstract Doc Link 11001897 Disease Relevance 0.63 Pain Relevance 0.08
PLAs cause microinfarction and exacerbate thrombus formation by enhancing the production of tissue factor.
Positive_regulation (enhancing) of Gene_expression (production) of tissue factor associated with thrombosis
12) Confidence 0.08 Published 2008 Journal Thromb J Section Body Doc Link PMC2330027 Disease Relevance 1.46 Pain Relevance 0.21
Probable mechanisms for this effect of hyperglycemia involve enhanced activation of proinflammatory transcription factors that can increase tissue factor expression (20).
Positive_regulation (increase) of Gene_expression (expression) of tissue factor associated with hyperglycemia
13) Confidence 0.06 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.04 Pain Relevance 0
Administration of LTPOCs produces local hypoxia stemming from reduced uterine vasomotion (45), and increases stromal cell expression of tissue factor, which can generate thrombin at local sites of AUB [46].
Positive_regulation (increases) of Gene_expression (expression) of tissue factor in uterine associated with uterine hemorrhage and hypoxia
14) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.63 Pain Relevance 0.14
Cell surface-based signaling system CD40L ligand (CD154), binding to its receptor CD40 on the leucocyte, can induce tissue factor expression [50].
Positive_regulation (induce) of Gene_expression (expression) of tissue factor in leucocyte
15) Confidence 0.02 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 0.97 Pain Relevance 0.27
Blood clotting is initiated when pathogenic components such as endotoxin or inflammatory cytokines induce the synthesis of tissue factor on leukocytes [60].
Positive_regulation (induce) of Gene_expression (synthesis) of tissue factor in leukocytes associated with coagulation disorder, inflammation and cytokine
16) Confidence 0.01 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 1.53 Pain Relevance 0.38
In response to inflammatory molecules, complement, lymphokines and immune complexes, these cells subsequently secrete procoagulant tissue factor; tumor-associated macrophages express significantly higher levels of tissue factor than control cells [109,110].
Positive_regulation (levels) of Gene_expression (express) of tissue factor in macrophages associated with inflammation and cancer
17) Confidence 0.01 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 1.64 Pain Relevance 0.37
Besides, it enhances production of Tissue Factor and stimulates pathological angiogenesis (Autiero M et al. 2003).
Positive_regulation (enhances) of Gene_expression (production) of Tissue Factor associated with pathologic neovascularization
18) Confidence 0.01 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.08 Pain Relevance 0.12
Local hemodynamic forces play an important role in thrombogenesis in at least two ways: first, physically, as modulators of endothelial function [13,14] by decreasing the vasodilator substances prostacyclin and nitric oxide, or by increasing the vasocontrictor endothelin-1; second, as in situ modulators of clotting balance (triggering platelet activation and over-expression of tissue factor), of fibrinolysis, and of thrombin generation.
Positive_regulation (triggering) of Gene_expression (over) of tissue factor in platelet associated with coagulation disorder
19) Confidence 0.01 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.26 Pain Relevance 0.21
Local hemodynamic forces play an important role in thrombogenesis in at least two ways: first, physically, as modulators of endothelial function [13,14] by decreasing the vasodilator substances prostacyclin and nitric oxide, or by increasing the vasocontrictor endothelin-1; second, as in situ modulators of clotting balance (triggering platelet activation and over-expression of tissue factor), of fibrinolysis, and of thrombin generation.
Positive_regulation (triggering) of Gene_expression (expression) of tissue factor in platelet associated with coagulation disorder
20) Confidence 0.01 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.26 Pain Relevance 0.21

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