INT84561

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 11.76
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
cartilage 2
face 2
cortical bone 1
parathyroid 1
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain score 4 99.48 Very High Very High Very High
Paracetamol 9 98.68 Very High Very High Very High
Osteoarthritis 131 98.52 Very High Very High Very High
Analgesic 5 98.12 Very High Very High Very High
backache 15 98.04 Very High Very High Very High
palliative 1 95.88 Very High Very High Very High
rheumatoid arthritis 53 93.68 High High
Pain 20 92.64 High High
Restless leg syndrome 8 90.88 High High
Arthritis 84 90.24 High High
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 10 100.00 Very High Very High Very High
Pain 19 99.48 Very High Very High Very High
Metastasis 15 98.88 Very High Very High Very High
Osteolysis 9 98.66 Very High Very High Very High
Osteoarthritis 138 98.52 Very High Very High Very High
Hypercalcemia 41 98.28 Very High Very High Very High
Low Back Pain 19 98.04 Very High Very High Very High
Disease 156 96.44 Very High Very High Very High
Cancer 8 96.44 Very High Very High Very High
Multiple Myeloma 29 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urinary cross-linked N-terminal telopeptides of type I collagen (NTX) were measured by enzyme-linked immunosorbent assay, and chronic back pain was evaluated by face scale score at baseline and every 6 months in both groups.
type I collagen Binding (cross-linked) of in face associated with low back pain and backache
1) Confidence 0.47 Published 2004 Journal Clin. Rheumatol. Section Abstract Doc Link 15278749 Disease Relevance 0.87 Pain Relevance 0.32
Cross-linked carboxyterminal telopeptide of type I collagen and pyridinoline, which are parameters of bone resorption, was markedly elevated with low bone mineral density.
type I collagen Binding (Cross-linked) of associated with hypercalcemia
2) Confidence 0.36 Published 2001 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 11483939 Disease Relevance 0.27 Pain Relevance 0.10
Biochemical tests were normal except for an increase in urinary excretion of the N-telopeptide cross-linking region of type I collagen (NTx).
type I collagen Binding (linking) of
3) Confidence 0.35 Published 2000 Journal J. Bone Miner. Res. Section Abstract Doc Link 11028460 Disease Relevance 0.32 Pain Relevance 0.32
Clinical symptoms and levels of urinary cross-linked N-telopeptides of type I collagen (NTx) were assessed before and 12 months after surgery.
type I collagen Binding (cross-linked) of
4) Confidence 0.35 Published 2002 Journal J Orthop Sci Section Abstract Doc Link 11819138 Disease Relevance 1.22 Pain Relevance 0.54
The BMD of the lumbar spine (L1-L4) measured by dual-energy X-ray absorptiometry, urinary crosslinked N-terminal telopeptides of type I collagen (NTX) measured by an enzyme-linked immunosorbent assay, and back pain evaluated by the face scale score were assessed at baseline, 6 months, and 12 months.
type I collagen Binding (crosslinked) of in face associated with backache
5) Confidence 0.35 Published 2003 Journal J Orthop Sci Section Abstract Doc Link 12898306 Disease Relevance 0.86 Pain Relevance 0.32
As shown in TablesĀ 6 and 7, the 17-peptide biomarkers were found to be degradation products of eight different proteins: alpha1 antitrypsin (A1AT, two peptides having overlapping sequences), collagen type I alpha 1 (COL1A1; five peptides and three of them having overlapping sequences), collagen type I alpha 2 (COL1A2; one peptide), collagen type III alpha 1 (COL3A1; one peptide), collagen type IX alpha 2 (COL9A2; one peptide), fibrinogen alpha (FGA; two peptides having overlapping sequences), fibrinogen beta (FGB; two peptides having overlapping sequences), and uromodulin (UMOD; three peptides having overlapping sequences).
collagen type I alpha 2 Binding (found) of associated with alpha-1-antitrypsin deficiency
6) Confidence 0.27 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.84 Pain Relevance 0.12
As shown in TablesĀ 6 and 7, the 17-peptide biomarkers were found to be degradation products of eight different proteins: alpha1 antitrypsin (A1AT, two peptides having overlapping sequences), collagen type I alpha 1 (COL1A1; five peptides and three of them having overlapping sequences), collagen type I alpha 2 (COL1A2; one peptide), collagen type III alpha 1 (COL3A1; one peptide), collagen type IX alpha 2 (COL9A2; one peptide), fibrinogen alpha (FGA; two peptides having overlapping sequences), fibrinogen beta (FGB; two peptides having overlapping sequences), and uromodulin (UMOD; three peptides having overlapping sequences).
COL1A2 Binding (found) of associated with alpha-1-antitrypsin deficiency
7) Confidence 0.27 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.89 Pain Relevance 0.12
The effect on osteolysis was examined with urinary calcium, hydroxyproline (OHP) and serum cross-linked carboxyterminal telopeptide region of type I collagen (ICTP) levels.
type I collagen Spec (examined) Binding (cross-linked) of associated with osteolysis
8) Confidence 0.17 Published 1999 Journal Med. Oncol. Section Abstract Doc Link 10523801 Disease Relevance 1.12 Pain Relevance 0.74
The type I collagen degradation marker ICTP (C-terminal telopeptide of type I collagen) and the cartilage markers CTX-II (C-terminal telopeptide fragments of type II collagen) and cartilage oligomeric matrix protein (COMP) were associated with the Larsen score at baseline.
type I collagen Binding (associated) of in cartilage
9) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.60 Pain Relevance 0.19
The purpose of the present study was to determine relationship between disease activity, systemic markers of cartilage degradation, urinary C-terminal cross-linking telopeptides of type II collagen (uCTX-II), and bone degradation, urinary C-terminal cross-linking telopeptides of type I collagen (uCTX-I), structural progression of osteoarthritis (OA) and potential therapeutic efficacy of type II collagen (COLLII) in combination with glucosamine and chondroitin sulfate (GC).


type I collagen Binding (linking) of in cartilage associated with disease and osteoarthritis
10) Confidence 0.09 Published 2008 Journal J Orthop Traumatol Section Abstract Doc Link PMC2656961 Disease Relevance 0.80 Pain Relevance 0.35
GC

Urinary C-terminal cross-linking telopeptides of type I collagen has a higher baseline in the EOA subgroup.

type I collagen Binding (linking) of
11) Confidence 0.09 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656961 Disease Relevance 0.26 Pain Relevance 0.13
The bone turnover markers bALP, PINP, Dickkopf 1 (DKK-1) and N-terminal crosslinked telopeptide of type I collagen (NTX-I) were measured together with parathyroid hormone (PTH), calcium and albumin during the study period.
type I collagen Binding (crosslinked) of in parathyroid
12) Confidence 0.08 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.17 Pain Relevance 0.03
Clinical symptoms, levels of urinary cross-linked N-telopeptides of type I collagen (NTx), and metacarpal cortical bone mineral density (BMD) were assessed before and just after the 6 months of treatment.
type I collagen Binding (cross-linked) of in cortical bone
13) Confidence 0.08 Published 2001 Journal J Orthop Sci Section Abstract Doc Link 11484118 Disease Relevance 0.70 Pain Relevance 0.39
Clinical symptoms, serum alkaline phosphatase, and urinary C-terminal cross-linking telopeptide of type I collagen were assessed every 3 months.
type I collagen Binding (linking) of
14) Confidence 0.08 Published 2003 Journal Bone Section Abstract Doc Link 14555262 Disease Relevance 0.30 Pain Relevance 0.14
These results show the differential effects of ibuprofen and acetaminophen on urinary excretion of peptide-bound and free deoxypyridinoline cross-links of type I collagen.
type I collagen Binding (cross-links) of associated with paracetamol
15) Confidence 0.06 Published 2001 Journal Bone Section Abstract Doc Link 11704495 Disease Relevance 0.25 Pain Relevance 0.86
Reduced Cox multivariate models identified five significant prognostic factors for first SRE (weight, race, high N-terminal cross-linked telopeptide of type I collagen (NTX), high pain score, and need for narcotic analgesics) and seven for survival (age, SRE history, myeloma subtype, anemia, high lactate dehydrogenase, high NTX, and low albumin levels).
type I collagen Binding (cross-linked) of associated with anaemia, pain score and analgesic
16) Confidence 0.05 Published 2010 Journal Leukemia Section Abstract Doc Link 20376081 Disease Relevance 0.97 Pain Relevance 0.20
Specific primers for type I collagen ?
type I collagen Binding (primers) of
17) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.09 Pain Relevance 0.13
Urinary cross-linked N-terminal telopeptides of type I collagen (NTX) and serum alkaline phosphatase (ALP) levels were measured by enzyme-linked immunosorbent assay and standard laboratory techniques, respectively.
type I collagen Binding (cross-linked) of
18) Confidence 0.03 Published 2005 Journal Aging Clin Exp Res Section Body Doc Link 15977465 Disease Relevance 0.15 Pain Relevance 0
[A possibility of the prognosis factor of serum cross-linked carboxyterminal telopeptide region of type I collagen (ICTP) as a marker of bone metastasis].
type I collagen Binding (cross-linked) of associated with metastasis
19) Confidence 0.02 Published 2002 Journal Kaku Igaku Section Title Doc Link 12607236 Disease Relevance 1.07 Pain Relevance 0.10

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