INT84564

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1999
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 1.86
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
synapses 4
spinal cord 2
nucleus 2
neurons 1
brain 1
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 294 100.00 Very High Very High Very High
Glutamate receptor 13 100.00 Very High Very High Very High
Opioid 4 99.84 Very High Very High Very High
GABAergic 3 99.84 Very High Very High Very High
substance P 7 99.36 Very High Very High Very High
c fibre 2 98.32 Very High Very High Very High
Periaqueductal grey 6 98.28 Very High Very High Very High
Neuropathic pain 1 98.04 Very High Very High Very High
Pain 8 97.20 Very High Very High Very High
qutenza 6 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 98.28 Very High Very High Very High
Neuropathic Pain 1 98.04 Very High Very High Very High
Pain 6 97.20 Very High Very High Very High
INFLAMMATION 1 97.20 Very High Very High Very High
Injury 3 95.52 Very High Very High Very High
Frailty 2 95.44 Very High Very High Very High
Anxiety Disorder 152 89.20 High High
Nociception 1 33.04 Quite Low
Shock 40 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following infusion, rats were trained, then sacrificed 24 hours after training as in our previous experiments, and Western blotting was performed on LA homogenates to determine whether training-induced activation of GluR1, synapsin, and synaptophysin at LA synapses is regulated by intra-LA infusion of each of these drugs (Figure 5a).
Spec (whether) Regulation (regulated) of Spec (whether) Positive_regulation (activation) of GluR1 in synapses associated with amygdala
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.17 Pain Relevance 0.36
Western blotting on tissue taken from around the cannula tips in the LA was then performed to determine whether training-induced activation of GluR1, synapsin, and synaptophysin at LA synapses is regulated by intra-LA infusion of each of these drugs.
Spec (whether) Regulation (regulated) of Spec (whether) Positive_regulation (activation) of GluR1 in synapses associated with amygdala
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.55 Pain Relevance 0.39
In the present study, we have examined whether activation of different glutamate receptor subtypes modulates the release of substance P evoked by the C-fiber selective stimulant capsaicin (1 microM) from rat trigeminal nucleus slices.
Regulation (modulates) of Spec (whether) Positive_regulation (activation) of glutamate receptor in nucleus associated with c fibre, qutenza, glutamate receptor and substance p
3) Confidence 0.28 Published 1999 Journal Neurochem. Int. Section Abstract Doc Link 10524715 Disease Relevance 0.20 Pain Relevance 1.25
This study attempted to define the role of activation of the kainic acid/2-amino-3(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) and metabotropic glutamate receptor subtypes in the regulation of opioid peptide expression and the onset of spontaneous and evoked pain-related behavior following excitotoxic spinal cord injury by comparing quisqualic acid-induced changes with those created by co-injection of quisqualic acid and the kainic acid/AMPA antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline, (NBQX) or the metabotropic antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA).
Regulation (regulation) of Positive_regulation (activation) of glutamate receptor in spinal cord associated with pain, antagonist, glutamate receptor, opioid and spinal cord
4) Confidence 0.20 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440816 Disease Relevance 0.61 Pain Relevance 0.87
The effect of metabotropic glutamate receptor (mGluR) activation on GABAergic synaptic transmission in rat periaqueductal grey (PAG) neurons was examined using whole-cell patch-clamp recordings in brain slices.
Spec (examined) Regulation (effect) of in neurons Spec (examined) Positive_regulation (activation) of glutamate receptor in brain associated with periaqueductal grey, gabaergic and glutamate receptor
5) Confidence 0.12 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15081789 Disease Relevance 0.34 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox