INT84570

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.67
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rgs2) plasma membrane (Rgs2) nucleus (Rgs2)
cell cycle (Rgs2) cytoplasm (Rgs2)
Anatomy Link Frequency
plasma 4
blood 2
cardiac myocytes 2
Rgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 97.28 Very High Very High Very High
opioid receptor 6 91.56 High High
agonist 12 47.60 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 70 79.28 Quite High
Targeted Disruption 9 76.56 Quite High
Ganglion Cysts 28 67.84 Quite High
Coronary Heart Disease 39 56.56 Quite High
Sprains And Strains 2 53.76 Quite High
Natriuresis 15 50.00 Quite Low
Body Weight 15 5.00 Very Low Very Low Very Low
Hypertrophy 12 5.00 Very Low Very Low Very Low
Hypertension 10 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous deletion of RGS2 in mice increases blood pressure by impairing the ability of the nitric oxide-cGMP pathway to promote vascular relaxation because inhibition of vasoconstrictor-triggered G?
Positive_regulation (increases) of Gene_expression (deletion) of RGS2 in blood
1) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2650719 Disease Relevance 0.61 Pain Relevance 0
After 2 h, the expression of RGS2 increased by 5.9-fold (in the cytosol) and 8.6-fold (at the plasma membrane) in ANP-treated when compared with untreated cells.Fig. 4HEK293 cells coexpressing GC-A, PKG I?
Positive_regulation (increased) of Gene_expression (expression) of RGS2 in plasma
2) Confidence 0.41 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.06 Pain Relevance 0
Collectively, our findings are compatible with the notion that PKG I is the downstream target activated by the ANP/GC-A/cGMP-signalling pathway in cardiac myocytes. cGMP/PKG I-mediated modulation of RGS2 and subsequent inhibition of AT1/G?
Positive_regulation (mediated) of Gene_expression (modulation) of RGS2 in cardiac myocytes
3) Confidence 0.41 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 4, ANP (10 nM, incubation for 30, 60 and 120 min) caused a time-dependent increase in the total expression of RGS2 as well as in the amount of RGS2 associated with the plasma membrane.
Positive_regulation (increase) of Gene_expression (expression) of RGS2 in plasma
4) Confidence 0.41 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Overexpression of RGS2, but not the other RGS subtypes, produced a rightward shift in the morphine concentration-response curve.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of RGS2 associated with morphine
5) Confidence 0.36 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525062 Disease Relevance 0 Pain Relevance 0.67

General Comments

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