INT84573

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Context Info
Confidence 0.01
First Reported 1999
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.37
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mavs) mitochondrion (Mavs) signal transducer activity (Mavs)
Anatomy Link Frequency
melanophores 1
Mavs (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 6 99.24 Very High Very High Very High
Morphine 6 91.44 High High
Hippocampus 54 87.72 High High
cva 6 76.80 Quite High
Inflammation 60 75.52 Quite High
agonist 1 25.00 Low Low
long-term potentiation 24 5.00 Very Low Very Low Very Low
Thalamus 24 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
medulla 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 480 94.32 High High
Vascular Disease 48 93.68 High High
Disease 48 89.84 High High
Targeted Disruption 513 87.28 High High
Amyloid Plaque 114 87.00 High High
Hemorrhage 6 76.80 Quite High
INFLAMMATION 63 75.52 Quite High
Convulsion 3 62.60 Quite High
Amyloidosis 6 49.92 Quite Low
Neurodegenerative Disease 27 39.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a APPSLPS1M146L mouse model developed by Sanofi-Aventis, a hAPP751 gene carrying both the Swedish and the London mutations (K670N/M671L and V717I) under the control of the Thy-1 promoter is associated with a human mutant gene of presenilin-1 (PS-1 M146L) under the HMG-CoA reductase promoter (allowing a preferential cerebral expression).
Regulation (under) of promoter
1) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.23 Pain Relevance 0
The Tg2576 mouse line [137] overexpresses the 695 isoform of hAPP with the Swedish double mutation (K670N/M671L) under the control of the hamster prion protein promoter.
Regulation (control) of promoter
2) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.35 Pain Relevance 0.04
Line H6 also expresses hAPP with the Indiana mutation under the control of a PDGF promoter [344].


Regulation (control) of promoter
3) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.79 Pain Relevance 0.08
The goal of the present study was to investigate a possible role for regulators of G protein-signaling (RGS) proteins in opioid receptor (OR) desensitization using cultured Xenopus laevis dermal melanophores.
Spec (possible) Regulation (role) of protein-signaling in melanophores associated with opioid receptor
4) Confidence 0.00 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525062 Disease Relevance 0 Pain Relevance 0.37

General Comments

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