INT84593

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.74
Pain Relevance 3.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal 2
nerve 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 10 100.00 Very High Very High Very High
Inflammation 4 99.76 Very High Very High Very High
Spinal cord 42 99.20 Very High Very High Very High
Dorsal horn 3 97.92 Very High Very High Very High
long-term potentiation 1 97.08 Very High Very High Very High
allodynia 29 96.76 Very High Very High Very High
Neuropathic pain 50 95.32 Very High Very High Very High
central sensitization 1 94.48 High High
agonist 2 92.88 High High
Stimulus evoked pain 4 91.44 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.76 Very High Very High Very High
Nervous System Injury 4 98.48 Very High Very High Very High
Nociception 5 98.40 Very High Very High Very High
Neuropathic Pain 81 96.76 Very High Very High Very High
Pain 16 91.44 High High
Hypersensitivity 4 91.04 High High
Injury 4 87.84 High High
Sleep Disorders 3 84.24 Quite High
Targeted Disruption 1 75.60 Quite High
Hyperalgesia 3 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a functional subunit of NMDAR, NR1 phosphorylation is significantly increased in the ipsilateral spinal cord after nerve injury and coincides with mechanical allodynia [28].
Positive_regulation (increased) of NMDAR Binding (subunit) of in nerve associated with nervous system injury, allodynia and spinal cord
1) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 1.05 Pain Relevance 1.81
The physiological role of dynorphin A binding to the NMDAR remains to be established.
Positive_regulation (role) of NMDAR Binding (binding) of associated with dynorphin
2) Confidence 0.44 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525097 Disease Relevance 0 Pain Relevance 0.57
Here, we reported that a polyamine deficient diet (PD diet) for 7 days prevented the enhancement of tyrosine phosphorylation of the spinal NR2B subunit-containing NMDA-R associated with inflammation in rats.
Positive_regulation (enhancement) of NMDA-R Binding (associated) of in spinal associated with inflammation
3) Confidence 0.41 Published 2008 Journal Pain Section Abstract Doc Link 17900809 Disease Relevance 1.20 Pain Relevance 0.61
MMP activity is required for the NMDA-induced loss of extracellular NR1-epitopes
Positive_regulation (required) of NR1 Binding (loss) of
4) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.28
MMP activity is required for the NMDA-induced loss of extracellular NR1-epitopes
Positive_regulation (induced) of NR1 Binding (loss) of
5) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.28
The regulation of excitatory and inhibitory signal transduction indicates a shift in the balance toward increased excitability, where the glutamatergic N-methyl-d-aspartate receptor complex together with cholinergic system is up-regulated and the gamma-aminobutyric acid type A receptor system is down-regulated.
Positive_regulation (up-regulated) of N-methyl-d-aspartate receptor Binding (complex) of
6) Confidence 0.13 Published 2010 Journal J. Neurophysiol. Section Abstract Doc Link 19939961 Disease Relevance 0.49 Pain Relevance 0.19

General Comments

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