INT84594

Context Info Confidence 0.43 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.59

aging (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2) transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)

Anatomy Link Frequency kidney 2 Aqp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 6 99.24 agonist 3 84.56 anesthesia 1 25.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increase in free water clearance with clonidine administration was associated with a reduction in whole kidney AQP-2 mRNA levels (282+/-25 versus 216+/-11 A units, p<.05).

Negative_regulation (reduction) of Transcription (levels) of AQP-2 in kidney associated with clonidine

1) Confidence 0.43 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525117 Disease Relevance 0 Pain Relevance 0.59

General Comments

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