INT846

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Context Info
Confidence 0.70
First Reported 1979
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 42
Total Number 46
Disease Relevance 29.78
Pain Relevance 8.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (B2M) plasma membrane (B2M)
Anatomy Link Frequency
plasma 3
BEN 2
urine 2
blood 2
macrophages 1
B2M (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 16 99.76 Very High Very High Very High
Inflammation 13 99.44 Very High Very High Very High
Analgesic 13 99.44 Very High Very High Very High
Paracetamol 25 99.32 Very High Very High Very High
spinal inflammation 10 99.32 Very High Very High Very High
Pain 26 98.20 Very High Very High Very High
tolerance 1 96.88 Very High Very High Very High
Angina 1 95.86 Very High Very High Very High
corticosteroid 3 94.80 High High
Dopamine 8 91.60 High High
Disease Link Frequency Relevance Heat
Leukocytosis 1 99.90 Very High Very High Very High
Balkan Nephropathy 12 99.84 Very High Very High Very High
Chronic Renal Failure 3 99.84 Very High Very High Very High
Disease 83 99.78 Very High Very High Very High
Alzheimer's Dementia 18 99.78 Very High Very High Very High
Carpal Tunnel Syndrome 16 99.76 Very High Very High Very High
Renal Insufficiency 1 99.72 Very High Very High Very High
Hypercalcemia 3 99.68 Very High Very High Very High
Amyloidosis 44 99.62 Very High Very High Very High
INFLAMMATION 16 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amyloidosis resulting from an increase in beta 2-microglobulin level were excluded by both histological and immunohistochemical examinations.
Positive_regulation (increase) of beta 2-microglobulin associated with amyloidosis
1) Confidence 0.70 Published 1991 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 1985800 Disease Relevance 0.78 Pain Relevance 0.15
This syndrome has been called hemodialysis-related amyloidosis (HRA) and appears to be the result of the accumulation of polymerized Beta-2 microglobulin (B2M).
Positive_regulation (accumulation) of B2M associated with amyloidosis and syndrome
2) Confidence 0.69 Published 1990 Journal ASAIO Trans Section Abstract Doc Link 2306386 Disease Relevance 1.06 Pain Relevance 0.09
This syndrome has been called hemodialysis-related amyloidosis (HRA) and appears to be the result of the accumulation of polymerized Beta-2 microglobulin (B2M).
Positive_regulation (accumulation) of Beta-2 microglobulin associated with amyloidosis and syndrome
3) Confidence 0.69 Published 1990 Journal ASAIO Trans Section Abstract Doc Link 2306386 Disease Relevance 1.06 Pain Relevance 0.09
Higher levels of beta-2-microglobulin in patients with ankylosing spondylitis could be attributed to activation of monocyte macrophages system in subpopulation of cytotoxic T-lymphocytes, which might be the evidence of the involvement of cytotoxic-T cell mechanisms in the pathogenesis of this disease.
Positive_regulation (levels) of beta-2-microglobulin in macrophages associated with spinal inflammation and disease
4) Confidence 0.69 Published 1990 Journal Cas. Lek. Cesk. Section Abstract Doc Link 2189571 Disease Relevance 0.70 Pain Relevance 0.42
The precise mechanism of the build-up of this amyloid is not known, though a massive and chronic increase in beta-2-microglobulin in the blood of haemodialyzed patients is thought to be mainly responsible.
Positive_regulation (increase) of beta-2-microglobulin in blood associated with alzheimer's dementia
5) Confidence 0.68 Published 1989 Journal Cas. Lek. Cesk. Section Abstract Doc Link 2655913 Disease Relevance 0.83 Pain Relevance 0.13
The results showed that when R value was more than 40%, the clinical manifestation of amyloidosis carpal tunnel syndrome induced by increase of beta 2-microglobulin was alleviated obviously.
Positive_regulation (increase) of beta 2-microglobulin associated with amyloidosis and carpal tunnel syndrome
6) Confidence 0.68 Published 1996 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 9387629 Disease Relevance 0.20 Pain Relevance 0.10
The increase in serum beta2-microglobulin, neopterin and 2-5A-synthetase was more sustained.
Positive_regulation (increase) of beta2-microglobulin
7) Confidence 0.67 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10496186 Disease Relevance 0.15 Pain Relevance 0.16
The increase of beta-2-microglobulin concentration during hemodialysis tratment was due probably by hemoconcentration.
Positive_regulation (increase) of beta-2-microglobulin
8) Confidence 0.67 Published 1991 Journal Srp Arh Celok Lek Section Abstract Doc Link 1796332 Disease Relevance 0.67 Pain Relevance 0.32
Antibodies to and elevations of beta 2 microglobulin in the serum of ankylosing spondylitis patients.
Positive_regulation (elevations) of 2 microglobulin associated with spinal inflammation
9) Confidence 0.53 Published 1982 Journal Arthritis Rheum. Section Title Doc Link 6176246 Disease Relevance 0.61 Pain Relevance 0.31
The persistently elevated plasma beta-2 microglobulin levels may play a role in the pathogenesis of this recently recognized complication, and if so, this complication should be preventable.
Positive_regulation (elevated) of beta-2 microglobulin in plasma
10) Confidence 0.53 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3310621 Disease Relevance 0.79 Pain Relevance 0.07
Both are associated with cystic lesions of bone and are related to synovioarticular deposition of a new type of amyloid derived from circulating beta 2-microglobulin.
Positive_regulation (circulating) of beta 2-microglobulin associated with alzheimer's dementia
11) Confidence 0.49 Published 1989 Journal Clin Radiol Section Abstract Doc Link 2752686 Disease Relevance 0.86 Pain Relevance 0.09
Another hypothetical possibility is that a small increase in tubular reabsorption of both creatinine and beta2-microglobulin would account for the observed increases in creatinine and beta2-microglobulin in serum.
Positive_regulation (increase) of beta2-microglobulin
12) Confidence 0.48 Published 1979 Journal Acta Med Scand Section Abstract Doc Link 104553 Disease Relevance 0.31 Pain Relevance 0.11
Another hypothetical possibility is that a small increase in tubular reabsorption of both creatinine and beta2-microglobulin would account for the observed increases in creatinine and beta2-microglobulin in serum.
Spec (observed) Positive_regulation (increases) of beta2-microglobulin
13) Confidence 0.48 Published 1979 Journal Acta Med Scand Section Abstract Doc Link 104553 Disease Relevance 0.29 Pain Relevance 0.11
It is concluded that, although statistically significant, the increases in serum creatinine and beta2-microglobulin are small and therefore of little relevance for the patient's treatment with cimetidine.
Positive_regulation (increases) of beta2-microglobulin
14) Confidence 0.48 Published 1979 Journal Acta Med Scand Section Abstract Doc Link 104553 Disease Relevance 0.27 Pain Relevance 0.11
It encompasses all the disorders of mineral and bone metabolism associated with chronic renal insufficiency, i.e. secondary hyperparathyroidism, retention and accumulation of beta 2 microglobulin and aluminum.
Positive_regulation (accumulation) of beta 2 microglobulin associated with hypercalcemia and chronic renal insufficiency
15) Confidence 0.47 Published 2004 Journal Acta Med Croatica Section Abstract Doc Link 15125393 Disease Relevance 1.32 Pain Relevance 0
Since patients with elevated serum beta-2 microglobulin achieved lower CR rate and shorter PFS when treated with frontline chemoimmunotherapy (FCR), for this subgroup of high-risk patients a trial to evaluate the safety and efficacy of FCR combined with alemtuzumab is ongoing at the MDACC.
Positive_regulation (elevated) of beta-2 microglobulin
16) Confidence 0.45 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004569 Disease Relevance 0.87 Pain Relevance 0.05
However, mild inflammatory signs, raised serum LDH, predominantly of LDH 3, lymphocytic pleocytosis and elevated beta 2 microglobulin in CSF suggested neurolymphomatosis.
Positive_regulation (elevated) of beta 2 microglobulin associated with marek disease, inflammation and leukocytosis
17) Confidence 0.42 Published 1998 Journal No To Shinkei Section Abstract Doc Link 9989361 Disease Relevance 1.13 Pain Relevance 0.18
Our data confirm the presence of beta 2-microglobulin in haemodialysis-associated amyloidosis, and also suggest a possible role for alpha 2-microglobulin: it may protect beta 2-microglobulin from proteolytic digestion, leading to its accumulation in intact form and to amyloid fibril formation.
Spec (may) Positive_regulation (protect) of 2-microglobulin associated with amyloidosis and alzheimer's dementia
18) Confidence 0.42 Published 1989 Journal Clin. Sci. Section Abstract Doc Link 2470544 Disease Relevance 0.50 Pain Relevance 0.07
Our data confirm the presence of beta 2-microglobulin in haemodialysis-associated amyloidosis, and also suggest a possible role for alpha 2-microglobulin: it may protect beta 2-microglobulin from proteolytic digestion, leading to its accumulation in intact form and to amyloid fibril formation.
Spec (possible) Positive_regulation (role) of 2-microglobulin associated with amyloidosis and alzheimer's dementia
19) Confidence 0.42 Published 1989 Journal Clin. Sci. Section Abstract Doc Link 2470544 Disease Relevance 0.50 Pain Relevance 0.07
Given the relatively short times spent on high flux hemodialysis in both groups, increased beta 2-microglobulin removal is unlikely to account for this phenomenon.
Positive_regulation (increased) of beta 2-microglobulin
20) Confidence 0.42 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9328948 Disease Relevance 0.30 Pain Relevance 0.06

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