INT8462

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 1.79
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC7)
Anatomy Link Frequency
Blood 2
pore 2
plasma 1
pancreas 1
cerebral cortex 1
MUC7 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 12 99.90 Very High Very High Very High
cerebral cortex 4 98.44 Very High Very High Very High
ischemia 8 98.32 Very High Very High Very High
agonist 15 95.04 Very High Very High Very High
Glutamate 15 93.76 High High
nMDA receptor 6 82.80 Quite High
Glutamate receptor 4 73.56 Quite High
Pyramidal cell 3 58.60 Quite High
Spinal cord 2 54.32 Quite High
Neurotransmitter 2 53.16 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 6 98.32 Very High Very High Very High
Pressure And Volume Under Development 2 98.16 Very High Very High Very High
Decapitation 2 95.12 Very High Very High Very High
Pancreatitis 2 90.08 High High
Appetite Loss 2 88.96 High High
Cancer 83 88.64 High High
Pancreatic Cancer 1 88.24 High High
Adenocarcinoma 3 85.20 High High
Brain Hemorrhage 2 84.68 Quite High
Death 7 65.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whole brain and cerebral cortex were weighed and synaptic plasma membranes were prepared from cortex for the determination of Na+,K+-ATPase and Mg2+-ATPase activities.
Mg2 Spec (determination) Binding (determination) of in cerebral cortex associated with cerebral cortex
1) Confidence 0.36 Published 1998 Journal Neuroreport Section Abstract Doc Link 9665589 Disease Relevance 0.18 Pain Relevance 0.08
EXPERIMENTAL DESIGN: Total RNA from 16 pancreatic tumors, 10 chronic pancreatitis tissues, 7 normal pancreas tissues, and 15 pancreatic tumor cell lines were analyzed by reverse transcription-PCR with primers specific for MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7 genes and by RNA slot blot analyses.
MUC7 Spec (analyses) Binding (specific) of in pancreas
2) Confidence 0.36 Published 2001 Journal Clin. Cancer Res. Section Body Doc Link 11751498 Disease Relevance 0.35 Pain Relevance 0
Blood normally contains Mg2+ bound to proteins, Mg2+ complexed to small anion ligands and free ionized Mg2+ (IMg2+).
Mg2 Binding (bound) of in Blood
3) Confidence 0.22 Published 1996 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 8865438 Disease Relevance 0 Pain Relevance 0
Blood normally contains Mg2+ bound to proteins, Mg2+ complexed to small anion ligands and free ionized Mg2+ (IMg2+).
Mg2 Binding (bound) of in Blood
4) Confidence 0.22 Published 1996 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 8865438 Disease Relevance 0 Pain Relevance 0
Estimation of the IMg2+ level in serum or plasma by analysis of ultrafiltrates (complexed Mg + IMg2+) is somewhat unsatisfactory, as the methods employed do not distinguish the truly ionized form from Mg2+ bound to organic and inorganic anions.
Mg2 Binding (bound) of in plasma
5) Confidence 0.22 Published 1996 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 8865438 Disease Relevance 0 Pain Relevance 0
It is suggested that local anesthetics can bind strongly to Ca2+ and Mg2+ binding centers, provided that a hydrophobic region is located nearby.
Mg2 Binding (bind) of associated with local anesthetic
6) Confidence 0.12 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2497745 Disease Relevance 0 Pain Relevance 0.54
Whole brain and cerebral cortex were weighed and synaptic plasma membranes were prepared from cortex for the determination of Na+,K+-ATPase and Mg2+-ATPase activities.
Mg2 Spec (determination) Binding (determination) of in brain associated with cerebral cortex
7) Confidence 0.12 Published 1998 Journal Neuroreport Section Abstract Doc Link 9665589 Disease Relevance 0.18 Pain Relevance 0.08
The effect on Ca2+ efflux was antagonized by the ligands of the ATPase (Mg2+, K+, Ca2+, MgATP, and ADP) and by the organic polyamines ruthenium red, spermine, spermidine, and putrescine.
Mg2 Binding (ligands) of
8) Confidence 0.05 Published 1992 Journal J. Biol. Chem. Section Abstract Doc Link 1372893 Disease Relevance 0 Pain Relevance 0.22
by competing for Mg2+, followed by the inactivation of Protein Phosphatase 1 and subsequent increased inhibitory phosphorylation of GSK3?
Mg2 Binding (competing) of
9) Confidence 0.03 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.18 Pain Relevance 0
Mg2+ also inhibited Ca2+ binding to the mitochondrial membrane, mitochondrial swelling, membrane protein thiol oxidation, and H2O2 generation induced by Ca2+.
Mg2 Binding (binding) of associated with pressure and volume under development
10) Confidence 0.03 Published 1998 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 9799563 Disease Relevance 0.17 Pain Relevance 0.08
Protons can compete with Ca2+ and Mg2+ for binding to the channel pore region and thereby relieve the channel block of monovalent cations [13,14].
Mg2 Binding (binding) of in pore
11) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.24 Pain Relevance 0.12
Mg2+ is bound at the second EF-hand, whereas Ca2+ is bound functionally at the third and fourth sites.
Mg2 Binding (bound) of
12) Confidence 0.01 Published 2008 Journal Biochemistry Section Abstract Doc Link 18201103 Disease Relevance 0 Pain Relevance 0
Within the channel pore, a binding site for magnesium (Mg2+) is located.
Mg2 Binding (binding) of in pore
13) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695219 Disease Relevance 0.24 Pain Relevance 0.50
At resting membrane potential, Mg2+ binds to this site, blocking ion flow (especially Ca2+) through the channel.
Mg2 Binding (binds) of
14) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695219 Disease Relevance 0.24 Pain Relevance 0.47

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