INT84638

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Context Info
Confidence 0.37
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.36
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1) lysosome (Smpd1)
Anatomy Link Frequency
fibroblast 1
Smpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1 98.00 Very High Very High Very High
cytokine 5 74.24 Quite High
Inflammatory stimuli 1 73.12 Quite High
cINOD 3 65.36 Quite High
agonist 6 34.00 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
antiepileptic Drug 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pick Disease Of The Brain 24 100.00 Very High Very High Very High
Disease 218 98.32 Very High Very High Very High
Rhinitis 1 91.68 High High
Stress 22 84.80 Quite High
Apoptosis 63 82.20 Quite High
Congenital Anomalies 22 75.00 Quite High
Infection 5 75.00 Quite High
INFLAMMATION 9 72.80 Quite High
Lysosome Storage Disease 4 70.16 Quite High
Toxicity 8 69.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From a practical standpoint, no patient should today be longer qualified of suffering from "Niemann-Pick disease" without specification of the subgroup, either acid sphingomyelinase deficiency or type C.


Regulation (suffering) of acid sphingomyelinase associated with pick disease of the brain
1) Confidence 0.37 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.79 Pain Relevance 0
treatment, involves another sphingomyelinase, probably an acidic SMase as reported [24], but not nSMase2.
Regulation (involves) of sphingomyelinase
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.55 Pain Relevance 0
Sphingomyelin accumulation appears related to lysosomal cholesterol storage, since sphingomyelinase activity can be strongly modulated in fibroblast cultures of Niemann-Pick C disease patients by incubation in presence or absence of low-density lipoprotein.
Regulation (modulated) of sphingomyelinase in fibroblast associated with disease
3) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.39 Pain Relevance 0
SEK1 is stimulated by a distinct mechanism involving phosphatidylcholine-phospholipase C and acidic sphingomyelinase.
Regulation (involving) of sphingomyelinase
4) Confidence 0.00 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10528195 Disease Relevance 0.63 Pain Relevance 0.22

General Comments

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