INT8465

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 10
Speculated 18
Reported most in Abstract
Documents 100
Total Number 118
Disease Relevance 36.03
Pain Relevance 44.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
platelets 8
blood 4
plasma 2
spinal 2
colon 2
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 167 100.00 Very High Very High Very High
aspirin 94 100.00 Very High Very High Very High
Pain 48 100.00 Very High Very High Very High
COX2 31 100.00 Very High Very High Very High
Analgesic 29 100.00 Very High Very High Very High
cOX1 25 100.00 Very High Very High Very High
acular 20 100.00 Very High Very High Very High
antagonist 13 100.00 Very High Very High Very High
intrathecal 11 100.00 Very High Very High Very High
sodium channel 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 172 100.00 Very High Very High Very High
Cancer 27 100.00 Very High Very High Very High
Renal Failure 2 99.92 Very High Very High Very High
Cough 29 99.88 Very High Very High Very High
Overactive Bladder 8 99.76 Very High Very High Very High
Ulcers 6 99.76 Very High Very High Very High
Coronary Artery Disease 2 99.76 Very High Very High Very High
Peritonitis 9 99.60 Very High Very High Very High
Osteoporosis 5 99.52 Very High Very High Very High
Ganglion Cysts 19 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its inhibiting effect on cyclooxygenase acts mainly peripherally but it could also act centrally.
Regulation (effect) of cyclooxygenase
1) Confidence 0.57 Published 1994 Journal Rev Prat Section Abstract Doc Link 7939282 Disease Relevance 0.57 Pain Relevance 1.32
Bone cells contain both inducible and constitutive prostaglandin G/H synthase (PGHS-2 and PGHS-1) and these are differentially regulated.
Regulation (regulated) of PGHS-1
2) Confidence 0.56 Published 1997 Journal J. Bone Miner. Res. Section Abstract Doc Link 9258749 Disease Relevance 0.33 Pain Relevance 0.43
Effects of cyclooxygenase-1 and -2 inhibition on gastric acid secretion and cardiovascular functions in rats.
Regulation (Effects) of cyclooxygenase-1 associated with cox1
3) Confidence 0.45 Published 2006 Journal Pharmacology Section Title Doc Link 16299412 Disease Relevance 0.09 Pain Relevance 0.19
We investigated the involvement of cyclooxygenase-1 and -2 in the regulation of gastric acid secretion and cardiovascular functions in anesthetized rats, after acute intravenous administration of the selective cyclooxygenase-1 inhibitor SC-560, the selective cyclooxygenase-2 inhibitor celecoxib and the nonselective inhibitor indomethacin.
Spec (investigated) Regulation (involvement) of cyclooxygenase-1
4) Confidence 0.45 Published 2006 Journal Pharmacology Section Abstract Doc Link 16299412 Disease Relevance 0.10 Pain Relevance 0.10
We studied the antinociceptive effect of intravenous and intrathecal injection of the cyclooxygenase inhibitor, ketorolac in acute UCD rats and its dependency on estrogen.
Regulation (dependency) of cyclooxygenase associated with acular, antinociceptive and intrathecal
5) Confidence 0.45 Published 2003 Journal Pain Section Abstract Doc Link 14499426 Disease Relevance 0.18 Pain Relevance 1.02
In the absence of anesthesia and recent surgery, intact awake female rats responded similarly to conscious male rats in that neither showed any response to cyclooxygenase inhibition.
Regulation (response) of cyclooxygenase associated with anesthesia
6) Confidence 0.45 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3344806 Disease Relevance 0.07 Pain Relevance 0.16
The effect of cyclooxygenase inhibitors on the low filling rate cystometrogram in urethane anesthetized rats.
Regulation (effect) of cyclooxygenase associated with anesthesia
7) Confidence 0.45 Published 1985 Journal J. Urol. Section Title Doc Link 3928908 Disease Relevance 0.16 Pain Relevance 0.10
Chronic leukotriene inhibition in the rat fails to modify the toxicological effects of a cyclooxygenase inhibitor.
Regulation (effects) of cyclooxygenase
8) Confidence 0.45 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 8143238 Disease Relevance 0.30 Pain Relevance 0.28
The effect of two widely used cyclooxygenase inhibitors (indomethacin and ketoprofen) on the low filling rate cystometrogram was investigated in urethane anesthetized rats.
Spec (investigated) Regulation (effect) of cyclooxygenase
9) Confidence 0.45 Published 1985 Journal J. Urol. Section Abstract Doc Link 3928908 Disease Relevance 0.14 Pain Relevance 0
Salicylamide shares important characteristics with salicylic acid including the lack of effect on cyclooxygenase and platelet aggregation as well as a close structural resemblance.
Regulation (effect) of cyclooxygenase in platelet
10) Confidence 0.45 Published 1994 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7846108 Disease Relevance 0 Pain Relevance 0.42
PURPOSE: Cyclooxygenase inhibitors decrease micturition frequency in animals with bladder inflammation but to our knowledge the influence of cyclooxygenase inhibitors on detrusor overactivity has not been investigated.
Regulation (influence) of cyclooxygenase in bladder associated with inflammation, pollakiuria and overactive bladder
11) Confidence 0.44 Published 2010 Journal J. Urol. Section Abstract Doc Link 20022033 Disease Relevance 0.37 Pain Relevance 0.17
To narrow the search for mediators involved in the increased production of sodium channels in large DRG neurons, we examined the effect of cyclooxygenase inhibition on sodium channel production during inflammation.
Spec (examined) Regulation (effect) of cyclooxygenase in neurons associated with dorsal root ganglion, inflammation and sodium channel
12) Confidence 0.44 Published 2004 Journal J Pain Section Abstract Doc Link 15219259 Disease Relevance 0.61 Pain Relevance 0.63
Given the putative involvement of trigeminal neuropeptides in the pathophysiology of these conditions, the influence of cyclooxygenase inhibitors (indomethacin, acetylsalicylic acid (ASA) and naproxen) has been studied upon substance P, calcitonin gene-related peptide and vasoactive intestinal peptide (VIP)-induced vasodilatation in PGF2 alpha precontracted porcine ophthalmic arteries in vitro.
Regulation (influence) of cyclooxygenase associated with aspirin, neuropeptide, increased venous pressure under development, calcitonin gene-related peptide and substance p
13) Confidence 0.43 Published 1992 Journal Cephalalgia Section Abstract Doc Link 1373109 Disease Relevance 0.18 Pain Relevance 0.51
Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery.
Regulation (Effects) of cyclooxygenase in mesentery associated with cox1
14) Confidence 0.43 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 11959090 Disease Relevance 0.25 Pain Relevance 0.29
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, have cancer chemopreventive properties by a mechanism that has been suggested to involve cyclooxygenase inhibition and reduction of prostaglandin (PGE2) levels in the target tissue.
Regulation (involve) of cyclooxygenase associated with inflammation, cancer and cinod
15) Confidence 0.43 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9230200 Disease Relevance 0.28 Pain Relevance 0.20
In conclusion, sildenafil induced antinociception, and its potentiation of the effect of the cyclooxygenase inhibitors nimesulide and diclofenac was probably mediated through the activation of the NO-cGMP pathway and inhibition of cyclic GMP degradation.
Regulation (effect) of cyclooxygenase associated with antinociception and diclofenac
16) Confidence 0.40 Published 2003 Journal Pharmacology Section Abstract Doc Link 14624058 Disease Relevance 0.23 Pain Relevance 0.61
Experiments were performed to investigate the effects of acute cyclooxygenase inhibition on renal hemodynamics in mid and late pregnant rats.
Spec (investigate) Regulation (effects) of cyclooxygenase
17) Confidence 0.39 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3111275 Disease Relevance 0 Pain Relevance 0
We conclude that furosemide elicits a nonuniform reflex response mediated via cardiac sympathetic afferents of which the renal sympathoinhibitory response is dependent on intact cyclooxygenase function.
Regulation (dependent) of cyclooxygenase in sympathetic
18) Confidence 0.39 Published 1994 Journal Hypertension Section Abstract Doc Link 8206629 Disease Relevance 0.08 Pain Relevance 0.14
We also studied the effects of prostaglandin E2 (PGE2), a cyclooxygenase product of arachidonic acid metabolism, on these nociceptors. 2.
Regulation (effects) of cyclooxygenase in PGE2 associated with nociceptor
19) Confidence 0.39 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2162922 Disease Relevance 0 Pain Relevance 0.61
In this study, the effects of the cyclooxygenase inhibitors phenylbutazone, diclofenac, indomethacin, acetylsalicyclic acid (ASA) and salicyclic acid (SA) on the motility of the Met-enkephalin- (FK) and acetylcholine- (ACh) stimulated isolated rat colon were observed.
Regulation (effects) of cyclooxygenase in colon associated with enkephalin and diclofenac
20) Confidence 0.38 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3928875 Disease Relevance 0 Pain Relevance 0.22

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