INT84672

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.76
Pain Relevance 8.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
spinal 4
sensory neurons 2
medulla 2
brain 2
nucleus 2
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 10 100.00 Very High Very High Very High
ganglionectomy 7 100.00 Very High Very High Very High
Calcium channel 2 100.00 Very High Very High Very High
Clonidine 4 99.84 Very High Very High Very High
tolerance 7 99.58 Very High Very High Very High
aspirin 2 99.56 Very High Very High Very High
Antinociceptive 10 99.38 Very High Very High Very High
anticonvulsant 2 99.20 Very High Very High Very High
Spinal cord 39 98.88 Very High Very High Very High
Morphine 25 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 36 95.92 Very High Very High Very High
Death 64 94.24 High High
Injury 10 93.64 High High
Diabetic Neuropathy 2 93.52 High High
INFLAMMATION 36 92.84 High High
Diarrhoea 2 92.32 High High
Convulsion 3 92.24 High High
Blepharoptosis 1 88.68 High High
Increased Venous Pressure Under Development 47 87.00 High High
Pain 26 85.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MPEP co-infused with morphine not only preserved the analgesia and retarded the development of antinociceptive tolerance, but also partially inhibited the up-regulation of spinal nNOS protein.
Negative_regulation (inhibited) of Positive_regulation (up-regulation) of nNOS in spinal associated with tolerance, antinociceptive, analgesia and morphine
1) Confidence 0.48 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18395342 Disease Relevance 0 Pain Relevance 1.47
The increases in nNOS protein and mRNA after splanchinic ganglionectomy were significantly reversed by clonidine treatment.
Negative_regulation (reversed) of Positive_regulation (increases) of nNOS protein associated with ganglionectomy and clonidine
2) Confidence 0.43 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.79
A corresponding increase in DRG nNOS protein was also observed and localized principally to small and occasionally medium-size sensory neurons.
Negative_regulation (localized) of Positive_regulation (increase) of nNOS in sensory neurons
3) Confidence 0.43 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.96 Pain Relevance 0.89
Nitroglycerin-induced nNOS increase in rat trigeminal nucleus caudalis is inhibited by systemic administration of lysine acetylsalicylate but not of sumatriptan.
Negative_regulation (inhibited) of Positive_regulation (increase) of nNOS in nucleus associated with aspirin and sumatriptan
4) Confidence 0.38 Published 2004 Journal Cephalalgia Section Title Doc Link 15154853 Disease Relevance 0 Pain Relevance 0.41
The increase in efficacy of anticonvulsant action correlated with a corresponding decrease of PCT-evoked increase in nNOS activity.
Negative_regulation (decrease) of Positive_regulation (increase) of nNOS associated with anticonvulsant
5) Confidence 0.37 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850575 Disease Relevance 0.25 Pain Relevance 0.52
On the other hand, attenuation of the spinal ERK phosphorylation by the MAPK kinase (MEK) inhibitor U0126 also could inhibit the increase of nNOS and iNOS expression in the spinal cord of morphine withdrawal rats.
Negative_regulation (inhibit) of Positive_regulation (increase) of nNOS in spinal associated with withdrawal, morphine and spinal cord
6) Confidence 0.36 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16712881 Disease Relevance 0.08 Pain Relevance 1.39
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Negative_regulation (inhibition) of Positive_regulation (regulation) of nNOS in motoneurons
7) Confidence 0.35 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03
The administration of either NMDA antagonist, CPP or ketamine, produced similar changes in NOS expression in the dorsal horns of monoarthritic rats; that is, a decrease in nNOS but increases in iNOS and eNOS.
Negative_regulation (decrease) of Positive_regulation (increases) of nNOS in dorsal horns associated with ketamine and antagonist
8) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.59 Pain Relevance 0.65
Nifedipine treatment decreased the brain nNOS activity, induced by multiple administration of morphine.
Negative_regulation (decreased) of Positive_regulation (induced) of nNOS in brain associated with morphine
9) Confidence 0.24 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15605124 Disease Relevance 0.34 Pain Relevance 0.94
Pretreating animals by microinjection into the bilateral RVLM of ERK activation inhibitor peptide II (1 nmol) or U0126 (5 pmol) significantly blunted the augmented NOS I or PKG protein expression at ventrolateral medulla during the pro-life phase (fig. 3).
Negative_regulation (blunted) of Positive_regulation (augmented) of NOS I in medulla associated with medulla and rostral ventrolateral medulla
10) Confidence 0.19 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.64 Pain Relevance 0.35
Carbachol inhibition of GH release in aggregates can be blocked by the calcium channel blockers cadmium and verapamil (594), consistent with the activation of nNOS by intracellular free calcium (3, 598).
Negative_regulation (blocked) of Positive_regulation (activation) of nNOS associated with calcium channel
11) Confidence 0.13 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.18
In earlier experiments it was also shown that COX-2 inhibition but not COX-1 inhibition can decrease the level of neuronal nitric oxide synthase induction as induced by NO donors [37].
Negative_regulation (decrease) of Positive_regulation (induction) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
12) Confidence 0.09 Published 2010 Journal J Headache Pain Section Body Doc Link PMC2995862 Disease Relevance 0.57 Pain Relevance 0.64

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