INT84673

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Context Info
Confidence 0.80
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 5.01
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
neuronal 3
dorsal horn 2
sympathetic 2
endothelium 2
sensory neurons 1
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 10 100.00 Very High Very High Very High
Dorsal horn 34 99.98 Very High Very High Very High
Kinase C 1 99.96 Very High Very High Very High
ketamine 32 99.62 Very High Very High Very High
COX2 20 98.64 Very High Very High Very High
intrathecal 16 98.40 Very High Very High Very High
Neurotransmitter 9 97.88 Very High Very High Very High
ganglionectomy 14 97.60 Very High Very High Very High
Thalamus 6 96.20 Very High Very High Very High
qutenza 31 94.00 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 8 99.42 Very High Very High Very High
Nervous System Injury 36 98.52 Very High Very High Very High
Injury 36 98.04 Very High Very High Very High
Death 23 97.60 Very High Very High Very High
Increased Venous Pressure Under Development 15 93.68 High High
Diabetic Neuropathy 2 93.52 High High
Erectile Dysfunction 100 91.00 High High
Spinal Cord Ischemia 15 89.48 High High
Apoptosis 14 89.44 High High
Stress 52 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double-label immunocytochemistry revealed no co-localization of c-Fos and nNOS in any brain region.
Localization (localization) of nNOS in brain
1) Confidence 0.80 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275410 Disease Relevance 0 Pain Relevance 0.84
In previous studies, neuronal nitric oxide synthase (nNOS) in the jejunal myenteric plexus, a key enzyme responsible for the release of NO, has been demonstrated to increase after splanchinic ganglionectomy (sympathetic nerve transection).
Localization (release) of nNOS in sympathetic associated with ganglionectomy and neuronal nitric oxide synthase
2) Confidence 0.75 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.43
VR1- and VRL-1-positive cells were distributed in the intralaryngeal ganglia and colocalization of capsaicin receptors with VIP, nNOS and cChAT was seen.
Localization (colocalization) of nNOS in ganglia
3) Confidence 0.74 Published 2004 Journal Acta Otolaryngol. Section Body Doc Link 15224886 Disease Relevance 0 Pain Relevance 0
A corresponding increase in DRG nNOS protein was also observed and localized principally to small and occasionally medium-size sensory neurons.
Localization (localized) of nNOS in sensory neurons
4) Confidence 0.70 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.96 Pain Relevance 0.89
Intrarenal injection of phenol in rats causes a persistent elevation in blood pressure (BP) and in norepinephrine (NE) secretion from the posterior hypothalamus (PH), and downregulation of neuronal nitric oxide synthase (nNOS) and interleukin-1beta (IL-1beta) in the PH.
Localization (secretion) of nNOS in hypothalamus associated with pressure and volume under development and neuronal nitric oxide synthase
5) Confidence 0.70 Published 2002 Journal Am. J. Hypertens. Section Abstract Doc Link 12160195 Disease Relevance 0.45 Pain Relevance 0.17
The colocalization of vanilloid receptors with common choline acetyltransferase (cChAT), vasoactive intestinal polypeptide (VIP), substance P (SP) and neuronal nitric oxide synthase (nNOS) was also studied using an immunohistochemical double-labeling technique.
Localization (colocalization) of nNOS in neuronal
6) Confidence 0.69 Published 2004 Journal Acta Otolaryngol. Section Body Doc Link 15224886 Disease Relevance 0 Pain Relevance 0
Evidence is gathering that a various of factors induced over-accumulation of intracellular calcium triggers proteases, lipase, protein kinase C, nitric oxide synthase, endonucleases, altered gene transcription, and release of free radicals, eventually producing neuronal injury and death.
Localization (release) of nitric oxide synthase in neuronal associated with kinase c, injury and death
7) Confidence 0.68 Published 2002 Journal BMC Neurol Section Body Doc Link PMC107739 Disease Relevance 0.93 Pain Relevance 0.41
In previous studies, neuronal nitric oxide synthase (nNOS) in the jejunal myenteric plexus, a key enzyme responsible for the release of NO, has been demonstrated to increase after splanchinic ganglionectomy (sympathetic nerve transection).
Localization (release) of neuronal nitric oxide synthase in sympathetic associated with ganglionectomy and neuronal nitric oxide synthase
8) Confidence 0.65 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.43
The colocalization of vanilloid receptors with common choline acetyltransferase (cChAT), vasoactive intestinal polypeptide (VIP), substance P (SP) and neuronal nitric oxide synthase (nNOS) was also studied using an immunohistochemical double-labeling technique.
Localization (colocalization) of neuronal nitric oxide synthase in neuronal
9) Confidence 0.65 Published 2004 Journal Acta Otolaryngol. Section Body Doc Link 15224886 Disease Relevance 0 Pain Relevance 0
In the right dorsal horn nNOS decreased by 57% and 59% at 6 and 24 hours after intrathecal administration of ketamine, respectively, whereas in the left dorsal horn nNOS decreased by 53% and 39% during the same periods (Figure 3b).
Localization (decreased) of nNOS in dorsal horn associated with ketamine, dorsal horn and intrathecal
10) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.12 Pain Relevance 0.73
The persistent upregulation of HSP27 and its colocalization with nNOS in surviving motor neurons may imply a keen competition in motor neuron survival between cytotoxic and cytoprotective systems.
Localization (colocalization) of nNOS in motor neurons
11) Confidence 0.58 Published 2003 Journal Arch. Histol. Cytol. Section Abstract Doc Link 12703557 Disease Relevance 0.27 Pain Relevance 0
The sections were incubated overnight with antisera to tyrosine hydroxylase, choline acetyl transferase, substance P, calcitonin-gene-related peptide, vasoactive intestinal peptide, somatostatin, neuropeptide Y, leucine-enkephalin, cholecystokinin octapeptide, brain-nitric oxide synthase, and endothelium-nitric oxide synthase.
Localization (antisera) of brain-nitric oxide synthase in endothelium
12) Confidence 0.52 Published 2009 Journal Spine Section Body Doc Link 19404173 Disease Relevance 0 Pain Relevance 0
CGRP-immunoreactive neurons (somata) were preferentially found in the jugular ganglion, whereas neurons immunoreactive for neuronal NO synthase were mostly localized in the nodose ganglion.
Localization (localized) of neuronal NO synthase in neurons
13) Confidence 0.34 Published 2008 Journal Neuropeptides Section Body Doc Link 18809208 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry of iNOS and nNOS
Localization (Immunohistochemistry) of nNOS
14) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.07 Pain Relevance 0.07
In our model, we did observe a reduction of COX2 mRNA levels after exposure to DETA/NO, which produces a controlled release of low amount of NO thus mimicking the production of nanomolar concentrations of NO by nNOS activity [45].
Localization (release) of nNOS associated with cox2
15) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0 Pain Relevance 0.21
Quantification of eNOS and nNOS proteins
Localization (Quantification) of nNOS
16) Confidence 0.28 Published 2010 Journal Int J Impot Res Section Body Doc Link PMC2959156 Disease Relevance 0.59 Pain Relevance 0
The action of these drugs are based upon intact NO releasing neural fibers (nNOS) and corporal endothelium (eNOS).
Neg (NO) Localization (releasing) of nNOS in endothelium
17) Confidence 0.14 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 0.95 Pain Relevance 0.16
Overall, these data suggest a role for NRS as mediated by NO in enhanced degeneration induced by ketamine in vitro and that blockage of nNOS may be beneficial for reducing the risk of pediatric use of ketamine (Wang et al., 2008).
Localization (blockage) of nNOS associated with ketamine
18) Confidence 0.13 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.67 Pain Relevance 0.28
Finally, we observed no colocalization of immunoreactive neuronal NOS (nNOS) with CGRP in the dorsal horn.
Neg (no) Localization (colocalization) of neuronal NOS in dorsal horn associated with dorsal horn
19) Confidence 0.02 Published 2000 Journal Brain Res. Section Abstract Doc Link 10760483 Disease Relevance 0 Pain Relevance 1.03

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