INT84676

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Context Info
Confidence 0.12
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.58
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
neurons 2
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 207 100.00 Very High Very High Very High
nav1.8 195 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
dorsal root ganglion 129 99.74 Very High Very High Very High
Peripheral sensitization 3 99.24 Very High Very High Very High
Kinase C 114 98.64 Very High Very High Very High
Pain 34 98.12 Very High Very High Very High
Hyperalgesia 15 97.84 Very High Very High Very High
Spinal cord 13 95.36 Very High Very High Very High
calcitonin gene related peptide 3 94.84 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 135 99.74 Very High Very High Very High
Pain 39 98.12 Very High Very High Very High
Hyperalgesia 15 97.84 Very High Very High Very High
Nociception 11 95.84 Very High Very High Very High
Inflammatory Pain 9 87.36 High High
INFLAMMATION 33 73.84 Quite High
Neuropathic Pain 9 58.28 Quite High
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Rupture 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rather than assaying SP release, in the present study we examined the effect of opioids on two postsynaptic measures of SP release, Fos expression and neurokinin-1 (NK-1) receptor internalization, in the rat.
Spec (examined) Regulation (effect) of Spec (examined) Positive_regulation (measures) of NK-1 associated with opioid and substance p
1) Confidence 0.12 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531466 Disease Relevance 0.19 Pain Relevance 0.98
Therefore, the modulatory action of NK-1 may be predominately mediated by PKC, particularly by PKC?
Regulation (modulatory) of Positive_regulation (action) of NK-1 associated with kinase c
2) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.45 Pain Relevance 1.49
It is conceivable that the modulation of Nav1.8 by NK-1 activation may contribute to peripheral sensitization of pain pathway.
Regulation (modulation) of Positive_regulation (activation) of NK-1 associated with pain, peripheral sensitization and nav1.8
3) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.53 Pain Relevance 1.34
is highly expressed in small-diameter DRG neurons and involved in NK-1 activation-induced potentiation of TRPV1 and the development of hyperalgesia [9,31-33].
Regulation (involved) of Positive_regulation (activation) of NK-1 in neurons associated with dorsal root ganglion and hyperalgesia
4) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.41 Pain Relevance 1.28

General Comments

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