INT84685

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Context Info
Confidence 0.60
First Reported 1999
Last Reported 2011
Negated 8
Speculated 2
Reported most in Body
Documents 67
Total Number 71
Disease Relevance 72.96
Pain Relevance 6.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
MG-63 2
SiHa 1
plasma 1
hepatocytes 1
HL-60 1
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 14 99.52 Very High Very High Very High
COX-2 inhibitor 378 99.28 Very High Very High Very High
aspirin 68 99.24 Very High Very High Very High
Inflammatory response 25 99.24 Very High Very High Very High
ischemia 31 99.20 Very High Very High Very High
qutenza 10 99.04 Very High Very High Very High
Morphine 9 95.88 Very High Very High Very High
Central nervous system 12 95.76 Very High Very High Very High
Inflammation 408 95.20 Very High Very High Very High
antagonist 93 94.80 High High
Disease Link Frequency Relevance Heat
Apoptosis 3097 100.00 Very High Very High Very High
Cancer 2077 99.84 Very High Very High Very High
Prostate Cancer 147 99.68 Very High Very High Very High
Paraganglioma 17 99.56 Very High Very High Very High
Osteogenic Sarcomas 15 99.44 Very High Very High Very High
Chronic Lymphoid Leukemia 21 99.34 Very High Very High Very High
Disease 368 99.20 Very High Very High Very High
Hemangiopericytoma 5 99.20 Very High Very High Very High
Cv General 4 Under Development 4 99.20 Very High Very High Very High
Cervical Cancer 31 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combined treatment of aspirin and radiation induces apoptosis by the regulation of bcl-2 and caspase-3 in human cervical cancer cell.
Regulation (regulation) of bcl-2 associated with aspirin, cervical cancer and apoptosis
1) Confidence 0.60 Published 2003 Journal Cancer Lett. Section Title Doc Link 12490308 Disease Relevance 0.75 Pain Relevance 0.51
We identified the regulation of apoptosis-responsive genes, bcl-2, caspase-3 and p53 after combined treatment.
Regulation (regulation) of bcl-2 associated with apoptosis
2) Confidence 0.60 Published 2003 Journal Cancer Lett. Section Abstract Doc Link 12490308 Disease Relevance 0.68 Pain Relevance 0.42
and PACAP do not directly overlap, some genes including the Bcl-2 family proteins are differentially regulated by these two factors.
Regulation (regulated) of Bcl-2
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.05 Pain Relevance 0.07
Down regulation of the anti-apoptotic protein, bcl-2 family, in injured portal tracts has been demonstrated to be a marker of ongoing apoptosis of cholangiocytes [85,86].
Regulation (regulation) of bcl-2 associated with apoptosis
4) Confidence 0.60 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.14 Pain Relevance 0.08
We studied the regulation of Bcl-2 family members in aspirin-induced apoptosis.
Regulation (regulation) of Bcl-2 associated with aspirin and apoptosis
5) Confidence 0.60 Published 2010 Journal Apoptosis Section Abstract Doc Link 19936928 Disease Relevance 1.13 Pain Relevance 0.59
Cimmino et al. then demonstrated that miR-15a and miR-16-1 expressions were inversely correlated to Bcl2 expression in CLL and that both miRNAs negatively regulated Bcl2 at a posttranscriptional level.
Regulation (regulated) of Bcl2 associated with chronic lymphoid leukemia
6) Confidence 0.53 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.21 Pain Relevance 0
Further knowledge of the actions and relations between BCL-2 family members is necessary to define the exact role of the bcl-2 protein and of other BCL-2 family members in the pathogenesis, prognosis, and response of metastatic CM to new treatments.


Regulation (role) of bcl-2 associated with skin cancer
7) Confidence 0.44 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 0.60 Pain Relevance 0
Further knowledge of the actions and relations between BCL-2 family members is necessary to define the exact role of the bcl-2 protein and of other BCL-2 family members in the pathogenesis, prognosis, and response of metastatic CM to new treatments.


Regulation (role) of BCL-2 associated with skin cancer
8) Confidence 0.44 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 0.60 Pain Relevance 0
Oridonin activated the caspase 3–dependent apoptotic pathway through up-regulation of Bax and down-regulation of Bcl-2, which promotes release of cytochrome c (Chen et al. 2005; Liu et al. 2006).
Regulation (regulation) of Bcl-2 associated with apoptosis
9) Confidence 0.44 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 1.41 Pain Relevance 0
Mitochondrial membrane permeabilization (MMP) may occur via the control of proapoptotic Bcl-2 family members, and/or by the induction of the mitochondrial permeability transition.
Regulation (control) of Bcl-2
10) Confidence 0.44 Published 2009 Journal Mol Nutr Food Res Section Abstract Doc Link 19051186 Disease Relevance 0.87 Pain Relevance 0
A mitochondrial permeability transition pore activator significantly abolished the anti-apoptotic effect of nicorandil in endothelial cells, indicating that the mechanism of protective effect of nicorandil is involved in the mitochondrial apoptotic pathway although it affects neither Bcl-2 nor Bax protein expression levels.
Neg (neither) Regulation (affects) of Bcl-2 in endothelial cells associated with apoptosis
11) Confidence 0.43 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16306793 Disease Relevance 0.94 Pain Relevance 0.05
All tumors showed immunoreactivity for CD34 and bcl-2.
Regulation (immunoreactivity) of bcl-2 associated with cancer
12) Confidence 0.43 Published 2007 Journal Brain Tumor Pathol Section Abstract Doc Link 18095142 Disease Relevance 1.17 Pain Relevance 0.13
The change in ratio of bax and bcl-2 seems to tilt the balance toward apoptosis, leading to the activation of caspase-3.
Regulation (change) of bcl-2 associated with apoptosis
13) Confidence 0.38 Published 1999 Journal J. Leukoc. Biol. Section Abstract Doc Link 10534122 Disease Relevance 0.92 Pain Relevance 0.84
Additionally, U69593 increased the content of the anti-apoptotic members of the Bcl-2 family of proteins, the Bcl-2 and Bcl-x(L), whereas it had no significant effect on the apoptosis-promoting homologues Bax, Bcl-x(S) and Bak.
Neg (no) Regulation (effect) of Bcl-2 associated with apoptosis
14) Confidence 0.37 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517294 Disease Relevance 0.90 Pain Relevance 0.62
For instance, miR-34a up-regulation corresponded with a down-regulation of BCL2 protein.
Regulation (regulation) of BCL2
15) Confidence 0.35 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2883962 Disease Relevance 0.61 Pain Relevance 0
Inhibition of miR-34a in Par-4-overexpressing cells resulted in an up-regulation of BCL2 protein with a corresponding decrease in apoptotic sensitivity to 5-FU.
Regulation (regulation) of BCL2 associated with apoptosis
16) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.47 Pain Relevance 0
Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells.
Regulation (regulation) of Bcl-2 associated with prostate cancer and apoptosis
17) Confidence 0.34 Published 2006 Journal Biol. Pharm. Bull. Section Title Doc Link 16880611 Disease Relevance 1.52 Pain Relevance 0.09
This was demonstrated by the ability of wild-type p53 to down-regulate Bcl-2 and up-regulate Bax and proceed to programmed cell death [31-33].
Regulation (regulate) of Bcl-2 associated with apoptosis
18) Confidence 0.31 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 1.10 Pain Relevance 0.10
Our data demonstrate that 3HFD treatment down-regulated Bcl-2 and significantly up-regulated the expression of Bax in MCF-7 cells.
Regulation (regulated) of Bcl-2 in MCF-7
19) Confidence 0.31 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 1.05 Pain Relevance 0.13
Furthermore, as discussed by Ferrieres and colleagues [50], these results suggest a loss in the control of Bcl-2 by progesterone in diseases originating from epithelial lobular components.
Regulation (control) of Bcl-2 associated with disease
20) Confidence 0.30 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1143573 Disease Relevance 0.53 Pain Relevance 0

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