INT84686

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 28.54
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
plasma 2
SiHa 1
endothelial cells 1
hepatocytes 1
HeLa 1
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 98.88 Very High Very High Very High
qutenza 24 98.76 Very High Very High Very High
cINOD 50 98.24 Very High Very High Very High
Morphine 9 95.88 Very High Very High Very High
Kinase C 4 94.72 High High
Pain 15 87.28 High High
opioid receptor 1 83.48 Quite High
Potency 2 83.20 Quite High
Opioid 8 83.04 Quite High
narcan 1 81.36 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1151 100.00 Very High Very High Very High
Stomach Cancer 25 99.58 Very High Very High Very High
Acute Renal Failure 166 99.44 Very High Very High Very High
Burns 148 99.22 Very High Very High Very High
Cancer 747 98.48 Very High Very High Very High
Prostate Cancer 26 98.08 Very High Very High Very High
Cervical Cancer 6 97.44 Very High Very High Very High
Leukemia 35 97.28 Very High Very High Very High
Death 158 96.80 Very High Very High Very High
Glioblastoma 48 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, U69593 increased the content of the anti-apoptotic members of the Bcl-2 family of proteins, the Bcl-2 and Bcl-x(L), whereas it had no significant effect on the apoptosis-promoting homologues Bax, Bcl-x(S) and Bak.
Neg (no) Regulation (effect) of Bax associated with apoptosis
1) Confidence 0.49 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517294 Disease Relevance 0.89 Pain Relevance 0.61
The change in ratio of bax and bcl-2 seems to tilt the balance toward apoptosis, leading to the activation of caspase-3.
Regulation (change) of bax associated with apoptosis
2) Confidence 0.44 Published 1999 Journal J. Leukoc. Biol. Section Abstract Doc Link 10534122 Disease Relevance 0.92 Pain Relevance 0.84
We determined the effects of exercise on bcl-2 family upstream of caspase-3, including caspase-9 and bax: bcl-2 ratio.
Spec (determined) Regulation (effects) of bax
3) Confidence 0.44 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.18 Pain Relevance 0
Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells.
Regulation (regulation) of Bax associated with prostate cancer and apoptosis
4) Confidence 0.36 Published 2006 Journal Biol. Pharm. Bull. Section Title Doc Link 16880611 Disease Relevance 1.51 Pain Relevance 0.09
The apoptotic regulatory proteins, which were analyzed, include the following: Bad, Bak, Mcl-1, Bcl-2, Bcl-x, Mdm-2, and Bax.
Regulation (following) of Bax associated with apoptosis
5) Confidence 0.32 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.58 Pain Relevance 0
In addition, burns septic ARF group plasma, but not control healthy plasma, induced the up-regulation of Bax and the down-regulation of Bcl-2 (Figure 4E), proteins known to modulate the mitochondrial apoptotic pathway.
Regulation (regulation) of Bax in plasma associated with acute renal failure, burns and apoptosis
6) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.49 Pain Relevance 0.03
Mitochondria-mediated apoptosis is regulated through anti-apoptotic (bcl-2) and pro-apoptotic (bax and bad) proteins of the bcl-2 family.
Regulation (regulated) of bax associated with apoptosis
7) Confidence 0.26 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.46 Pain Relevance 0.03
Apoptosis in gastric cancer cells expressing wild-type p53 is induced through up-regulation of bax and down-regulation of bcl-2 and that regulation of the bax-bcl-2 heterodimer may be a major target of NSAIDs.
Regulation (regulation) of bax associated with cinod, apoptosis and stomach cancer
8) Confidence 0.26 Published 2008 Journal Cancer Invest. Section Abstract Doc Link 18798056 Disease Relevance 0.81 Pain Relevance 0.53
Apoptosis in gastric cancer cells expressing wild-type p53 is induced through up-regulation of bax and down-regulation of bcl-2 and that regulation of the bax-bcl-2 heterodimer may be a major target of NSAIDs.
Regulation (regulation) of bax associated with cinod, apoptosis and stomach cancer
9) Confidence 0.26 Published 2008 Journal Cancer Invest. Section Abstract Doc Link 18798056 Disease Relevance 0.80 Pain Relevance 0.53
Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells.
Regulation (Involvement) of Bax in HL-60 associated with leukemia, qutenza and apoptosis
10) Confidence 0.26 Published 2006 Journal Anticancer Res. Section Title Doc Link 16827131 Disease Relevance 0.66 Pain Relevance 0.72
Immunofluorescence staining of MCF-7 cells was also performed to confirm the up-regulation of the Bax protein.


Regulation (regulation) of Bax in MCF-7
11) Confidence 0.25 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2873331 Disease Relevance 0.75 Pain Relevance 0
In this study, the NCTD-induced apoptosis in HepG2 cells was accompanied by up-regulation of Bax and the down-regulation of Bcl-2, suggesting that NCTD induced apoptosis in HepG2 cells by modulating Bcl-2 family proteins.
Regulation (regulation) of Bax associated with apoptosis
12) Confidence 0.24 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 2.00 Pain Relevance 0
Apoptosis was caused by decreasing the level of the anti-apoptotic protein Bcl-2 and up-regulation of pro-apoptotic Bax.
Regulation (regulation) of Bax associated with apoptosis
13) Confidence 0.22 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 1.30 Pain Relevance 0.04
Modified radical mastectomy was performed in all patients three weeks after the last cycle and the specimen were re-evaluated for any change in the bcl-2/bax ratio.
Regulation (change) of bax
14) Confidence 0.20 Published 2004 Journal BMC Cancer Section Abstract Doc Link PMC514705 Disease Relevance 1.00 Pain Relevance 0
Preconditioning causes a decrease in pro-apoptotic Bax and increase in the anti-apoptotic Bcl-2 proteins resulting in an altered Bcl-2/Bax ratio and attenuation of cytochrome c release from mitochondria (Maulik et al 1999, 2000; Nakamura et al 2000).
Regulation (altered) of Bax associated with apoptosis
15) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 1.22 Pain Relevance 0.15
Alterations in the levels of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins are known to regulate the commitment to apoptosis [14,15].
Regulation (Alterations) of Bax associated with apoptosis
16) Confidence 0.19 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.83 Pain Relevance 0.03
Modulation of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) gene expression in isolated porcine hepatocytes perfused within a radial-flow bioreactor after low-temperature storing.
Regulation (Modulation) of Bax in hepatocytes associated with apoptosis
17) Confidence 0.18 Published 2003 Journal Int J Artif Organs Section Title Doc Link 12653348 Disease Relevance 0.37 Pain Relevance 0
Thus, down-regulation of the Bcl-2/Bax expression ratio could be a predominant mechanism by which DLS induces mitochondria-mediated apoptosis in HepG2 cells.
Regulation (regulation) of Bax associated with apoptosis
18) Confidence 0.18 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 1.15 Pain Relevance 0.03
A mitochondrial permeability transition pore activator significantly abolished the anti-apoptotic effect of nicorandil in endothelial cells, indicating that the mechanism of protective effect of nicorandil is involved in the mitochondrial apoptotic pathway although it affects neither Bcl-2 nor Bax protein expression levels.
Neg (neither) Regulation (affects) of Bax protein in endothelial cells associated with apoptosis
19) Confidence 0.18 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16306793 Disease Relevance 0.94 Pain Relevance 0.05
Seven genes (ATM, BAX, CCNA2, CDC27, RAD50 and p21) were prominently altered, and six (ATM, CCND2, CCNF, CDC20, CDK1A and RAD50) were commonly altered with both concentrations.
Regulation (altered) of BAX
20) Confidence 0.16 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372855 Disease Relevance 0.39 Pain Relevance 0.07

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