INT847

Context Info Confidence 0.61 First Reported 1977 Last Reported 2010 Negated 32 Speculated 10 Reported most in Abstract Documents 131 Total Number 141 Disease Relevance 22.08 Pain Relevance 46.54

Anatomy Link Frequency plasma 16 pituitary 5 neurons 3 blood 2 median eminences 2 Lhb (Mus musculus)

Pain Link Frequency Relevance Heat narcan 368 100.00 Opioid 149 100.00 agonist 83 100.00 Morphine 81 100.00 Endogenous opioid 73 100.00 antagonist 69 100.00 Dopamine 64 100.00 opiate 43 100.00 opioid receptor 25 100.00 ketamine 20 100.00

Disease Link Frequency Relevance Heat Opiate Addiction 12 100.00 Polycystic Ovary Syndrome 35 99.88 Stress 19 99.68 Eating Disorder 40 99.56 Syndrome 3 98.80 Apoptosis 21 98.44 Endometriosis (extended) 5 97.92 Breast Cancer 11 97.80 Advanced Or Metastatic Breast Cancer 9 97.80 Body Weight 26 97.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of chronic heroin addiction on LH biological and immunological activity, as well as on total and free testosterone concentrations, were investigated in 8 active young male addicts.

Spec (investigated) Regulation (effects) of LH associated with addiction and opiate addiction

1) Confidence 0.61 Published 1984 Journal Pharmacol Res Commun Section Abstract Doc Link 6522443 Disease Relevance 0.17 Pain Relevance 0.17

In this study we wished to test whether, and if so when, the suppressive effects of testosterone on LH and, by inference, GnRH secretion are mediated via endogenous opioid pathways during male pubertal maturation.

Spec (whether) Regulation (effects) of LH associated with endogenous opioid

2) Confidence 0.56 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1955505 Disease Relevance 0 Pain Relevance 0.20

These results suggest the involvement of opiate mechanisms in the regulation of LH self-stimulation.

Regulation (regulation) of LH associated with opiate

3) Confidence 0.45 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3174771 Disease Relevance 0 Pain Relevance 0.47

The influence of the suckling stimulus and ovarian secretions on LH response to naloxone was studied in 16 postpartum anestrous beef cows that were assigned randomly to one of four groups (n = 4/group): intact suckled (IS), intact nonsuckled (IN), ovariectomized suckled (OS) or ovariectomized nonsuckled (ON).

Regulation (influence) of LH associated with narcan

4) Confidence 0.45 Published 1989 Journal J. Anim. Sci. Section Abstract Doc Link 2670869 Disease Relevance 0 Pain Relevance 0.15

The purpose of this study was to re-evaluate the quantitative and qualitative responses of LH to exogenous and endogenous GnRH stimulation in normally cycling women and in polycystic ovarian disease (PCOD).

Regulation (responses) of LH associated with polycystic ovary syndrome

5) Confidence 0.45 Published 1991 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 1927298 Disease Relevance 0.34 Pain Relevance 0.17

To investigate whether changes in opioid tone play a role in the age-associated changes in LH release in men, the influence of an antiopioid, naltrexone, on plasma LH levels and LH pulses was studied in a group of young and elderly normal men.

Regulation (pulses) of LH in plasma associated with opioid

6) Confidence 0.44 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2909555 Disease Relevance 0.07 Pain Relevance 0.10

[Effect of blockade of opiate receptors by naloxone on lutropin (LH), follitropin (FSH) and testosterone secretion in patients after kidney transplantation].

Regulation ([Effect) of LH in kidney associated with narcan and opiate

7) Confidence 0.44 Published 1992 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 1326100 Disease Relevance 0 Pain Relevance 0.46

In oil-injected ovariectomized dwarf mice, the plasma LH response to GnRH treatment was reduced (p < 0.001), and GH administration normalized this response.

Regulation (response) of LH in plasma

8) Confidence 0.43 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8722619 Disease Relevance 0.45 Pain Relevance 0

In the follicular phase, after placebo treatment, the number and amplitude of LH pulses did not significantly vary, whereas mean LH levels (P < 0.01) and the LH response to GnRH (P < 0.05) were significantly increased.

Regulation (response) of LH response

9) Confidence 0.43 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0.06 Pain Relevance 0.36

In the follicular phase, after placebo treatment, the number and amplitude of LH pulses did not significantly vary, whereas mean LH levels (P < 0.01) and the LH response to GnRH (P < 0.05) were significantly increased.

Regulation (response) of LH

10) Confidence 0.43 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0.07 Pain Relevance 0.37

While compelling evidence indicates a pivotal role for endogenous opioids in the regulation of GnRH-LH pulsatile activity during the late follicular and luteal phases of the menstrual cycle, the participation, if any, of the opioidergic mechanism in the initiation of the midcycle surge has not been examined.

Regulation (regulation) of LH associated with endogenous opioid

11) Confidence 0.42 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3138276 Disease Relevance 0 Pain Relevance 0.23

There were no effects of drug treatment on LH concentration except for a small increase following sulpiride in November.

Neg (no) Regulation (effects) of LH

12) Confidence 0.39 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746749 Disease Relevance 0 Pain Relevance 0.55

Naloxone elevated the mean LH values in controls, but had no effects on LH pulse frequency or pulse amplitude.

Neg (no) Regulation (effects) of LH associated with narcan

13) Confidence 0.38 Published 2010 Journal Anim. Reprod. Sci. Section Abstract Doc Link 20462709 Disease Relevance 0.23 Pain Relevance 0.45

Response of LH to naloxone was determined in Exp. 3.

Regulation (Response) of LH associated with narcan

14) Confidence 0.37 Published 1988 Journal J. Anim. Sci. Section Abstract Doc Link 3230079 Disease Relevance 0 Pain Relevance 0.42

Despite producing very high circulating concentrations of CRF within 2 min of injection and the stimulation of cortisol secretion during most of the 4-h posttreatment period, plasma LH levels were not affected.

Neg (not) Regulation (affected) of LH in plasma

15) Confidence 0.37 Published 1990 Journal Endocrinology Section Abstract Doc Link 2201538 Disease Relevance 0.16 Pain Relevance 0.26

Opioid modulation of LH and prolactin (PRL) concentrations in Angus steers was investigated.

Regulation (modulation) of LH associated with opioid

16) Confidence 0.37 Published 1988 Journal J. Anim. Sci. Section Abstract Doc Link 3230079 Disease Relevance 0 Pain Relevance 0.27

In a second experiment, the LH response to GnRH (5 microg i.v.) was examined in ovariectomized hinds (n = 5) following administration of a serotonin infusion (6.6 microg kg(-1) min(-1) i.v. for 15 min), cyproheptadine (3 mg kg(-1) i.v. as a single dose) or vehicle, in the breeding season (July) after induction of halothane anaesthesia and in the non-breeding season (December) without anaesthesia.

Regulation (response) of LH response associated with halothane and serotonin

17) Confidence 0.33 Published 1999 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 10735553 Disease Relevance 0 Pain Relevance 0.40

In conclusion, although, the transient painful stress of NS does not affect the LH values, it alters the opioidergic and catecholaminergic-modulation of LH secretion.

Neg (not) Regulation (affect) of LH associated with stress and pain

18) Confidence 0.32 Published 2010 Journal Anim. Reprod. Sci. Section Abstract Doc Link 20462709 Disease Relevance 0.25 Pain Relevance 0.48

This relationship of the response of LH to the resting levels also held in several other pathological states in which there were marked differences of androgen and estrogen status as well as up to a 100-fold variation in basal LH concentrations.

Regulation (response) of LH

19) Confidence 0.32 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6785301 Disease Relevance 0.09 Pain Relevance 0.43

The effects of a potent LH-RH receptor antagonist, [Ac-4-Cl-D-Phe1,2,D-Trp3,D-Arg6,D-Ala10]LH-RH (ORG 30276), on the behavioral actions of the LH-RH agonist, D-Trp-6-LH-RH, were studied in mice.

Regulation (effects) of LH-RH associated with antagonist and agonist

20) Confidence 0.31 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1594632 Disease Relevance 0 Pain Relevance 0.38

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