INT84700

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 30.22
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) response to stress (HSP90B2P)
Anatomy Link Frequency
gut 2
kidney 2
skin 2
Plasma 1
hepatocytes 1
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 225 99.84 Very High Very High Very High
cINOD 10 99.60 Very High Very High Very High
projection neuron 1 97.36 Very High Very High Very High
antinociception 6 96.36 Very High Very High Very High
tolerance 88 92.20 High High
diclofenac 2 86.00 High High
Crohn's disease 196 83.68 Quite High
antidepressant 1 82.76 Quite High
Angina 1 80.60 Quite High
Paracetamol 6 80.28 Quite High
Disease Link Frequency Relevance Heat
Shock 331 100.00 Very High Very High Very High
Purpura 48 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 13 100.00 Very High Very High Very High
Stress 260 99.98 Very High Very High Very High
INFLAMMATION 211 99.84 Very High Very High Very High
Fever 115 99.84 Very High Very High Very High
Cv General 2 Under Development 35 99.80 Very High Very High Very High
Cancer 109 99.68 Very High Very High Very High
Targeted Disruption 168 99.64 Very High Very High Very High
Coronary Artery Disease 2 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because anti-hsp-antibody titres might be of prognostic value for coronary artery disease, patients with an increased hsp antibody titre should obtain intensive management of classical risk factors.
Positive_regulation (increased) of hsp in coronary artery associated with coronary artery disease
1) Confidence 0.67 Published 2000 Journal Cardiology Section Abstract Doc Link 11326141 Disease Relevance 1.01 Pain Relevance 0.08
Both inhibitors up-regulated the hsp promoter at 37 degrees C through the activation of heat shock factors, and increased cellular levels of hsps in mammalian cells, although the degree of the expression of hsps and thermotolerance of cells differed depending on the drugs.
Positive_regulation (increased) of hsp associated with shock
2) Confidence 0.67 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15560796 Disease Relevance 0.59 Pain Relevance 0.42
It has been reported that mild stress induces HSP in a variety of tissues, which prevents tissue injury against more severe stress.
Positive_regulation (induces) of HSP associated with stress and injury
3) Confidence 0.56 Published 2007 Journal Nippon Rinsho Section Abstract Doc Link 17926542 Disease Relevance 0.71 Pain Relevance 0.15
Epigallocatechin gallate (EGCG) did not extend C. elegans lifespan but attenuated the age-related behavioral decline [36] and extended survival rate under heat stress and oxidative stress by inducing SOD-3 and HSP-16.2 [37].
Positive_regulation (inducing) of HSP associated with stress, lifespan and heat stress disorders
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2822842 Disease Relevance 0.91 Pain Relevance 0.24
This suggests that the augmented spinal noradrenergic activity during HSP is not due to activation at the terminal of noradrenergic spinal projection neurons but requires supraspinal activity.
Positive_regulation (augmented) of HSP in projection neurons associated with projection neuron
5) Confidence 0.49 Published 1999 Journal Pain Section Abstract Doc Link 10534609 Disease Relevance 0 Pain Relevance 0.94
Plasma heat shock protein (HSP) 70 levels were higher in the two fever groups than in the other groups (P < 0.05).
Positive_regulation (higher) of HSP in Plasma associated with cv general 2 under development and fever
6) Confidence 0.45 Published 2005 Journal Shock Section Abstract Doc Link 15897803 Disease Relevance 1.42 Pain Relevance 0.16
BACKGROUND/AIM: Geranylgeranylacetone (GGA) enhances gastric mucosal protection against nonsteroidal anti-inflammatory drugs by upregulating mucosal heat shock proteins (HSP), but the effects of GGA on the human gastric mucosa have not been well examined.
Positive_regulation (upregulating) of HSP associated with inflammation, shock and cinod
7) Confidence 0.31 Published 2007 Journal Digestion Section Abstract Doc Link 17684364 Disease Relevance 0.35 Pain Relevance 0.18
These findings underscore the potential that abnormal immune responses to HSP may affect the clinical relevance of the disease, thus suggesting a direct pathogenic relationship.
Positive_regulation (responses) of HSP associated with disease
8) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 1.31 Pain Relevance 0.33
Immunological proinflammatory responses to HSP-peptides correlate with disease activity
Positive_regulation (responses) of HSP associated with disease
9) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.69 Pain Relevance 0.27
Immunological proinflammatory responses to HSP-peptides correlate with histologic data
Positive_regulation (responses) of HSP
10) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.37 Pain Relevance 0.16
These data confirm a plethora of reports supporting the upregulation and immunodominant role for HSP in inflammation.
Positive_regulation (upregulation) of HSP associated with inflammation
11) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.90 Pain Relevance 0.44
The babB gene sequences of our hsp-Amerind isolates were compared to the sequences previously reported for Amerindian isolates from Venezuela by Ghose et al. [16] by multiple sequence alignment and phylogenetic analysis (Figure 1B).
Positive_regulation (sequences) of hsp
12) Confidence 0.15 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553449 Disease Relevance 0.31 Pain Relevance 0
Although there have been many past studies on Hsp, our study is the first to investigate Hsp induction from the perspective of using it as a preconditioning treatment for corneal tissue in an in vivo system.
Spec (investigate) Positive_regulation (induction) of Hsp
13) Confidence 0.08 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.38 Pain Relevance 0
The density of the immunoreaction product in the corneal epithelium became greater, especially at the limbus, reflecting an increased accumulation of Hsp 70.
Positive_regulation (accumulation) of Hsp in corneal epithelium
14) Confidence 0.08 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.49 Pain Relevance 0.12
This is consistent with the finding that protection against light-induced degeneration of rat retinal photoreceptors is conferred by prior whole-body hyperthermia, which induces retinal Hsp 70 (7).
Positive_regulation (induces) of Hsp in body associated with fever
15) Confidence 0.08 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.77 Pain Relevance 0.11
The major heat shock protein Hsp 70 can be synthesized in a wide variety of cells such as rat islet cells, cardiomyocytes or cultured hepatocytes in response to heat or cold treatment, and it is known that the degree of Hsp 70 induction varies according to the recovery time after the thermal stress (20-22).
Positive_regulation (induction) of Hsp in hepatocytes associated with stress and shock
16) Confidence 0.08 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.34 Pain Relevance 0
After heat shock, however, Western blot revealed a large amount of Hsp 70 induction.
Positive_regulation (induction) of Hsp associated with shock
17) Confidence 0.08 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.51 Pain Relevance 0.13
In vitro experiments show that while HSP mRNA is increased secondary to a stressor, the amount of HSPs produced is variable and is dependent on the magnitude of the stressor [40].


Positive_regulation (increased) of HSP
18) Confidence 0.07 Published 2003 Journal Crit Care Section Body Doc Link PMC270667 Disease Relevance 0.82 Pain Relevance 0
Of the many subgroups of the inducible form of Hsp 70; Hsp 70.1 and Hsp 70.3, a knockout mouse study of Hsp 70.1 was conducted.
Positive_regulation (inducible) of Hsp associated with targeted disruption
19) Confidence 0.06 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.89 Pain Relevance 0.06
Of the many subgroups of the inducible form of Hsp 70; Hsp 70.1 and Hsp 70.3, a knockout mouse study of Hsp 70.1 was conducted.
Positive_regulation (inducible) of Hsp associated with targeted disruption
20) Confidence 0.06 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.89 Pain Relevance 0.06

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