INT84701

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.37
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) response to stress (HSP90B2P)
Anatomy Link Frequency
spinal 1
skeletal muscle 1
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
antinociception 6 99.98 Very High Very High Very High
abdominal pain 1 98.56 Very High Very High Very High
Inflammation 24 94.32 High High
Angina 1 93.84 High High
tolerance 44 93.16 High High
projection neuron 1 85.04 High High
rheumatoid arthritis 10 84.72 Quite High
analgesia 2 81.04 Quite High
Antinociceptive 1 70.56 Quite High
Opioid 2 69.92 Quite High
Disease Link Frequency Relevance Heat
Shock 13 100.00 Very High Very High Very High
Purpura 10 100.00 Very High Very High Very High
Ataxia 7 100.00 Very High Very High Very High
Autoimmune Disease 3 100.00 Very High Very High Very High
Atherosclerosis 3 99.76 Very High Very High Very High
Disease 210 99.72 Very High Very High Very High
Muscle Disease 3 99.36 Very High Very High Very High
Abdominal Pain 1 98.56 Very High Very High Very High
Neuromuscular Disease 1 98.44 Very High Very High Very High
Dermatomyositis 3 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, hypogastric neurectomy abolishes the component of the antinociception associated with HSP that is mediated by spinal alpha(2) receptors.
HSP Binding (associated) of in spinal associated with antinociception
1) Confidence 0.47 Published 1999 Journal Pain Section Abstract Doc Link 10534609 Disease Relevance 0 Pain Relevance 0.81
HSP may be confused with other systemic autoimmune diseases because they all can present with similar symptoms.
HSP Binding (present) of associated with purpura and autoimmune disease
2) Confidence 0.33 Published 2006 Journal Cutis Section Abstract Doc Link 16706241 Disease Relevance 1.47 Pain Relevance 0.10
Antibodies (Ab) to heat shock proteins (hsp) have been reported to be associated with atherosclerosis.
hsp Binding (associated) of associated with atherosclerosis and shock
3) Confidence 0.24 Published 2002 Journal Cardiovasc. Pathol. Section Abstract Doc Link 12140130 Disease Relevance 1.00 Pain Relevance 0.09
Indeed, our disease network also links HSP to a number of muscular diseases such as Dermatomyositis and Muscular Dystrophies (Table 1 and Supplementary Table S6 online).
HSP Binding (links) of associated with ataxia, muscular dystrophy, muscle disease, dermatomyositis and disease
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715883 Disease Relevance 2.01 Pain Relevance 0
Furthermore, both receptors also bind to the endogenous 60 kDa HSP (HSP60), leading to cell activation [10,11].
HSP Binding (bind) of
5) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.41 Pain Relevance 0.16
The dissociation of AR from HSP was also in the top 2% of sensitive interactions for both C-33 and C-81.
HSP Binding (interactions) of
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.15 Pain Relevance 0
No study has so far been published investigating the association between the ORAC and HSP levels.
HSP Binding (association) of
7) Confidence 0.02 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.45 Pain Relevance 0
Our purpose was to investigate the interaction between glucose metabolism, antioxidative capacity and heat shock protein (HSP) defence in different skeletal muscle phenotypes among middle-aged obese subjects during a long-term exercise and dietary intervention.
HSP Binding (interaction) of in skeletal muscle associated with obesity and shock
8) Confidence 0.02 Published 2008 Journal BMC Endocr Disord Section Abstract Doc Link PMC2330145 Disease Relevance 0.89 Pain Relevance 0.13

General Comments

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