INT84703

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 7.10
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) cytoplasm (Nqo1)
Anatomy Link Frequency
neurons 1
bands 1
optic 1
dorsal horn 1
Nqo1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 33 99.54 Very High Very High Very High
Multiple sclerosis 39 99.24 Very High Very High Very High
Spinal cord 20 99.10 Very High Very High Very High
Paracetamol 30 98.84 Very High Very High Very High
Dorsal horn 16 96.36 Very High Very High Very High
alcohol 4 96.08 Very High Very High Very High
allodynia 11 95.32 Very High Very High Very High
medulla 1 78.52 Quite High
transdermal 1 70.92 Quite High
tetrodotoxin 1 68.92 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 212 100.00 Very High Very High Very High
Necrosis 5 99.60 Very High Very High Very High
Optic Neuritis 33 99.54 Very High Very High Very High
Demyelinating Disease 82 99.24 Very High Very High Very High
Transverse Myelitis 38 97.28 Very High Very High Very High
Hepatotoxicity 6 96.20 Very High Very High Very High
Neuropathic Pain 11 95.32 Very High Very High Very High
Injury 10 93.76 High High
Cold Sores 2 92.36 High High
Autoimmune Disease 8 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The numbers of NADH-diaphorase and of each morphological type of NADPH-diaphorase positive neurons were obtained directly at the microscope by using a 40 × objective.
Negative_regulation (numbers) of NADH-diaphorase in neurons
1) Confidence 0.38 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1373636 Disease Relevance 0 Pain Relevance 0
In the presence of dicoumarol, however, QR activity was inhibited, and conversion of the toxic quinone metabolite back to APAP became inhibited and diminished the alcohol-dependent protective effect against APAP-induced hepatic injury.
Negative_regulation (inhibited) of QR associated with paracetamol, injury and alcohol
2) Confidence 0.32 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10535745 Disease Relevance 0.29 Pain Relevance 0.96
In mice pretreated with dicoumarol (30 mg/kg), an inhibitor of QR, hepatic necrosis caused by APAP (400 mg/kg) was potentiated.
Negative_regulation (inhibitor) of QR associated with necrosis and paracetamol
3) Confidence 0.28 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10535745 Disease Relevance 0.49 Pain Relevance 0.70
The elevated ganglionic NADPH-diaphorase and diminished CO labeling in the DRG of hyperglycemic mice is consistent with previously proposed inhibition of CO activity [24] by the product of nitric oxide synthase, nitric oxide.
Negative_regulation (diminished) of NADPH-diaphorase
4) Confidence 0.20 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1865541 Disease Relevance 0.19 Pain Relevance 0.26
Detection of NMO-IgG or AQP4 autoantibodies is clinically useful for early diagnosis of NMO and its related spectrum disorders (NMOSD), including single attack or recurrent LETM without ON, and recurrent ON without ATM; and especially early distinction between NMOSD and CMS [3].
Negative_regulation (Detection) of NMO-IgG associated with neuromyelitis optica, multiple sclerosis, transverse myelitis, demyelinating disease and neuritis
5) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 2.35 Pain Relevance 0.65
The researchers used this radioimmunoprecipitation assay to measure antibodies to AQP4 in sera from 37 patients with NMO and from six with another neurological condition, longitudinally extensive transverse myelitis (LETM), which is characterized by large demyelinated lesions across the width of the spinal cord but no optic neuritis; these patients often develop NMO.
Negative_regulation (develop) of NMO in optic associated with neuromyelitis optica, transverse myelitis, optic neuritis, neuritis and spinal cord
6) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance 1.36 Pain Relevance 0.25
The activity of reduced nicotinamide adenine dinucleotide phosphate diaphorase, an index of NOS1 activity, significantly increased in the laminae I and II of the lumbar dorsal horn of mice with postherpetic allodynia, but not mice without postherpetic allodynia.
Negative_regulation (reduced) of diaphorase in dorsal horn associated with allodynia and dorsal horn
7) Confidence 0.02 Published 2007 Journal Neuroscience Section Abstract Doc Link 17997045 Disease Relevance 1.71 Pain Relevance 1.24
Semiquantitative densitometric evaluation of the detected protein bands revealed that DBP levels were decreased in the NMO group by 34%.
Negative_regulation (decreased) of NMO in bands associated with neuromyelitis optica
8) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.71 Pain Relevance 0

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