INT84714

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Context Info
Confidence 0.25
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.50
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
muscle 2
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 7 99.72 Very High Very High Very High
antagonist 3 99.48 Very High Very High Very High
dexamethasone 8 98.88 Very High Very High Very High
aspirin 1 93.00 High High
substance P 6 85.28 High High
dorsal root ganglion 5 84.96 Quite High
cytokine 1 72.32 Quite High
IPN 1 69.44 Quite High
Spinal cord 1 65.28 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 3 100.00 Very High Very High Very High
Cancer 7 95.60 Very High Very High Very High
Eating Disorder 10 91.44 High High
Ganglion Cysts 5 84.96 Quite High
Frailty 3 76.24 Quite High
INFLAMMATION 2 75.00 Quite High
Aging 1 60.84 Quite High
Muscular Atrophy 1 45.36 Quite Low
Apoptosis 1 43.84 Quite Low
Stress 1 12.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, COX-1SV mRNA levels were elevated in colorectal tumours and reduced after NSAID treatment to the levels observed in normal colonic mucosa.
Negative_regulation (reduced) of Transcription (levels) of COX associated with colorectal cancer and cinod
1) Confidence 0.25 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.81 Pain Relevance 0.34
It was shown, for example, that a 24% reduction in food intake (versus ad libitum) for 7 days results in increased mRNA expression of COX enzyme subunits in rat muscle and that activity of COX and citrate synthase are increased by 21 days [16].
Negative_regulation (reduction) of Transcription (expression) of COX enzyme in muscle
2) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667640 Disease Relevance 0.31 Pain Relevance 0
Furthermore, a 1-h incubation with IL-1beta markedly increased the inducible COX-2 mRNA level, which was inhibited by an IL-1r antagonist and dexamethasone, whereas IL-1beta showed no effect on the level of constitutive COX-1 mRNA.
Negative_regulation (inhibited) of Transcription (level) of COX associated with antagonist and dexamethasone
3) Confidence 0.05 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10537081 Disease Relevance 0.38 Pain Relevance 0.83

General Comments

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