INT84716

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.34
Pain Relevance 6.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
Spleen 2
keratinocyte 2
prefrontal 2
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 100.00 Very High Very High Very High
chemokine 6 100.00 Very High Very High Very High
fluoxetine 11 99.84 Very High Very High Very High
withdrawal 5 99.80 Very High Very High Very High
dorsal root ganglion 5 99.52 Very High Very High Very High
Eae 5 99.36 Very High Very High Very High
ketamine 15 99.24 Very High Very High Very High
antagonist 3 98.52 Very High Very High Very High
Neuropathic pain 8 96.84 Very High Very High Very High
aspirin 1 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Ganglion Cysts 5 99.52 Very High Very High Very High
Injury 6 99.36 Very High Very High Very High
Gliosis 1 99.28 Very High Very High Very High
Neuropathic Pain 16 96.84 Very High Very High Very High
Nociception 2 96.40 Very High Very High Very High
Cognitive Disorder 1 96.08 Very High Very High Very High
Hyperalgesia 5 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human MSCs reduced the mRNA levels of the pro-inflammatory interleukin IL-1beta mouse gene, as well as the neural beta-galactosidase over-activation in prefrontal cortex of SNI mice.
Negative_regulation (reduced) of Positive_regulation (activation) of IL-1beta in prefrontal associated with inflammation
1) Confidence 0.57 Published 2010 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19937263 Disease Relevance 1.16 Pain Relevance 0.67
PSL-induced IL-1beta up-regulation was suppressed by anti-MIP-1alpha and siRNA against CCR1 and CCR5.
Negative_regulation (suppressed) of Positive_regulation (up-regulation) of IL-1beta
2) Confidence 0.42 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 0.97 Pain Relevance 1.16
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Negative_regulation (decreased) of Positive_regulation (levels) of IL-1beta in Spleen associated with withdrawal
3) Confidence 0.41 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.49
Meanwhile, cotreatment with ketamine and lipopolysaccharide significantly inhibited lipopolysaccharide-induced TNF-alpha, IL-1beta, and IL-6 mRNA levels.
Negative_regulation (inhibited) of Positive_regulation (lipopolysaccharide-induced) of IL-1beta associated with ketamine
4) Confidence 0.41 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.15 Pain Relevance 0.68
MDL-28170, but not (+)-MK-801 inhibited TNF and IL-1beta upregulation one hour after CCI.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of IL-1beta associated with eae
5) Confidence 0.41 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 0.99 Pain Relevance 0.69
KA-induced gliosis and proinflammatory marker (COX-2, IL-1beta, and TNF-alpha) inductions were also suppressed by fluoxetine administration.
Negative_regulation (suppressed) of Positive_regulation (inductions) of IL-1beta associated with gliosis and fluoxetine
6) Confidence 0.41 Published 2009 Journal Brain Res. Section Abstract Doc Link 19427844 Disease Relevance 0.74 Pain Relevance 1.18
When murine J774 macrophages were incubated with the sesquiterpene lactone, LPS-induced IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and keratinocyte-derived chemokine (KC) release were concentration-dependently inhibited.
Negative_regulation (inhibited) of Positive_regulation (induced) of IL-1beta in keratinocyte associated with chemokine, necrosis and cancer
7) Confidence 0.41 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.66 Pain Relevance 0.40
The increase in TNF-alpha levels preceded the increase in IL-1beta and KC/CXCL1.
Negative_regulation (preceded) of Positive_regulation (increase) of IL-1beta
8) Confidence 0.04 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.24
The effect of IL-1beta was Ca(2+)-dependent and significantly inhibited by 100 ng/ml IL-1 receptor-specific antagonist (IL-1r antagonist), cyclooxygenase (COX) inhibitors such as 0.1 mM aspirin, 1 microg/ml indomethacin, and 1 microM NS-398 (specific for COX-2), and 1 microM dexamethasone.
Negative_regulation (inhibited) of Positive_regulation (effect) of IL-1beta associated with aspirin, antagonist and dexamethasone
9) Confidence 0.02 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10537081 Disease Relevance 0.41 Pain Relevance 0.75

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