INT84722

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 7.73
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
EPI 8
blood 2
testes 2
C cells 2
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 191 100.00 Very High Very High Very High
adenocard 85 99.16 Very High Very High Very High
cINOD 7 98.46 Very High Very High Very High
positron emission tomography 5 98.40 Very High Very High Very High
antagonist 101 96.40 Very High Very High Very High
Catecholamine 42 95.56 Very High Very High Very High
Inflammation 11 89.84 High High
Potency 52 89.60 High High
imagery 7 78.08 Quite High
Central nervous system 2 53.32 Quite High
Disease Link Frequency Relevance Heat
Prostate Cancer 310 99.92 Very High Very High Very High
Reprotox - General 1 97 99.92 Very High Very High Very High
Stress 3 99.24 Very High Very High Very High
Cancer 230 98.48 Very High Very High Very High
Targeted Disruption 45 97.72 Very High Very High Very High
INFLAMMATION 16 97.32 Very High Very High Very High
Adhesions 16 97.28 Very High Very High Very High
Disease 56 96.20 Very High Very High Very High
Neurodegenerative Disease 9 95.40 Very High Very High Very High
Repression 8 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FA and other similar NSAIDs may be potential candidates for chemoprevention of human prostate cancer by modulating the expression of AR.
Regulation (modulating) of Gene_expression (expression) of AR associated with cinod and reprotox - general 1
1) Confidence 0.61 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.40 Pain Relevance 0.37
Furthermore, the AR expression in prostate and testes was not affected by treatment of mice with the siRNA selective for the human AR mRNA (Figure 2A) whereas this siRNA efficiently silenced AR in the human tumor cells and inhibited their growth in vivo (Figure 1E).
Neg (not) Regulation (affected) of Gene_expression (expression) of AR in testes associated with cancer
2) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.50 Pain Relevance 0
Fluoro-dihydrotestosterone (FDHT) is a biomarker of androgen receptor expression in human prostate cancer, and has been particularly useful in the setting of advanced prostate cancer, when the patient has castrate levels of circulating testosterone in the blood.
Regulation (biomarker) of Gene_expression (expression) of androgen receptor in blood associated with prostate cancer
3) Confidence 0.25 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.76 Pain Relevance 0.17
We then calculated the effect of these perturbation on cyclin D and PSA expression levels along with ERK and AR activation levels.
Regulation (effect) of Gene_expression (expression) of AR
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.49 Pain Relevance 0
In the model, PI3K was activated by androgen (in the absence of growth factor) because of the down-regulation of cPAcP expression by activated AR.
Regulation (regulation) of Gene_expression (expression) of AR
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.11 Pain Relevance 0
AIPC is characterized by androgen action in the absence of androgen stimulation.
Regulation (characterized) of Gene_expression (action) of androgen associated with prostate cancer
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 1.13 Pain Relevance 0
In addition to these genes, AARPCs exhibit changes in expression of the androgen receptor and enzymes involved in the sterol biosynthesis pathway [12].
Regulation (changes) of Gene_expression (expression) of androgen receptor
7) Confidence 0.14 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.04 Pain Relevance 0
The change in expression patterns of AR, 3?
Regulation (change) of Gene_expression (patterns) of AR
8) Confidence 0.14 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0.06 Pain Relevance 0
In addition to changes in expression of AR or interacting proteins altering the transcriptional activity of the AR, recent suggestion of sufficient levels of residual androgen in CRPC provides support for an active ligand-bound receptor [112].
Regulation (changes) of Gene_expression (expression) of AR associated with reprotox - general 1
9) Confidence 0.09 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.66 Pain Relevance 0
In the search for A2B AR agonists, de Zwart et al. reported a functional screening, based on adenylate cyclase stimulation, of known adenosine analogues variously modified at the 2-, 5-, 8-, N6 and 5?
Regulation (search) of Gene_expression (agonists) of AR associated with adenocard and agonist
10) Confidence 0.09 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.34
Altered expression of AR co-activators may occur in recurrent cancer, and AR mutations may occur in as many as 40%–50% of such cancers.
Regulation (Altered) of Gene_expression (expression) of AR associated with cancer
11) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504071 Disease Relevance 1.13 Pain Relevance 0
The A2A AR signals in both the periphery and the CNS, with agonists explored as anti-inflammatory drugs and antagonists explored for neurodegenerative diseases, e.g., Parkinson’s disease.7?
Regulation (The) of Gene_expression (signals) of AR associated with inflammation, antagonist, cinod, agonist, disease and neurodegenerative disease
12) Confidence 0.06 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2865168 Disease Relevance 0.39 Pain Relevance 0.40
2-AR signal is desensitized following chronic EPI but not NE treatment, consistent with the fact that NE has a low affinity for the ?
Regulation (desensitized) of Gene_expression (signal) of AR in EPI
13) Confidence 0.06 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.13
2A-AR signal with 24 hr EPI exposure is due, in part, to down-regulation of the receptor in SH?
Regulation (regulation) of Gene_expression (signal) of AR in EPI
14) Confidence 0.06 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.04
2A-AR desensitization and down-regulation also attenuated EPI-induced increase in GRK2 and GRK3 content in the membrane fraction (P < 0.05; Fig. 6).
Regulation (regulation) of Gene_expression (desensitization) of AR in EPI
15) Confidence 0.06 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
2-AR responsiveness in cells and tissues after chronic epinephrine (EPI) or norepinephrine (NE) exposure may vary, depending on the ?
Spec (may) Regulation (depending) of Gene_expression (responsiveness) of AR in EPI
16) Confidence 0.06 Published 2007 Journal BMC Pharmacol Section Abstract Doc Link PMC2234403 Disease Relevance 0.17 Pain Relevance 0
2A-AR desensitization and down-regulation in BE(2)-C cells is mediated via ?
Regulation (regulation) of Gene_expression (desensitization) of AR in C cells
17) Confidence 0.06 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.07
2A-AR desensitization and down-regulation in ?
Regulation (regulation) of Gene_expression (desensitization) of AR
18) Confidence 0.06 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
However, expression of AR probably was affected by additional mechanisms such as impairment of prostate development through effects on ER-?.
Regulation (affected) of Gene_expression (expression) of AR
19) Confidence 0.04 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0 Pain Relevance 0.08
Exposure to the VEEV down regulates the expression pattern of the gene coding for the androgen receptor and the Prostate androgen-regulated transcript 1 (PART1) (Fig. 7).
Regulation (regulates) of Gene_expression (expression) of androgen receptor
20) Confidence 0.04 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.64 Pain Relevance 0.09

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