INT84726

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.10
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NKX3-1) intracellular (NKX3-1) protein binding transcription factor activity (NKX3-1)
transcription factor binding (NKX3-1)
Anatomy Link Frequency
gut 1
mast cells 1
NKX3-1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 1 97.28 Very High Very High Very High
Inflammation 43 95.12 Very High Very High Very High
nud 2 93.56 High High
cINOD 5 91.88 High High
antagonist 4 89.96 High High
substance P 35 75.76 Quite High
cytokine 12 44.64 Quite Low
spastic colon 5 44.00 Quite Low
Nerve growth factor 19 38.08 Quite Low
Neuropeptide 27 37.68 Quite Low
Disease Link Frequency Relevance Heat
Hyperplasia 1 95.64 Very High Very High Very High
INFLAMMATION 39 95.12 Very High Very High Very High
Cancer 107 94.16 High High
Dyspepsia 2 93.56 High High
Apoptosis 2 93.40 High High
Disease 15 91.24 High High
Prostate Cancer 1 90.04 High High
Colon Cancer 1 84.64 Quite High
Hypersensitivity 4 83.20 Quite High
Diarrhoea 2 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FA dramatically reduced the expression of androgen inducible genes, such as prostate-specific antigen (PSA) and the homeo-domain transcription factor Nkx3.1, but PXM did not.
Gene_expression (expression) of Nkx3.1
1) Confidence 0.75 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.43 Pain Relevance 0.43
However, in the patient, we observed LOH deletion in AKT1, under-expression of AKT2, mTOR, elF4E, and over-expression of the negative regulators eIF4EBP1 and NKX3-1.
Gene_expression (expression) of NKX3-1
2) Confidence 0.61 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.82 Pain Relevance 0
Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases.
Gene_expression (expressed) of NK3 in gut associated with inflammation, nud and disease
3) Confidence 0.24 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16918330 Disease Relevance 0.69 Pain Relevance 0.16
Very recently, Bischoff and colleagues examined the expression of tachykinin receptors on human mast cells and found that human mast cells derived from intestinal mucosa do not constitutively express NK1, NK2, or NK3 receptors [65].
Neg (not) Gene_expression (express) of NK3 in mast cells
4) Confidence 0.02 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.17 Pain Relevance 0.15

General Comments

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